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Unlocking hope: The future of ustekinumab biosimilars in Crohn's disease treatment
Publication Year: 2025 Source: United European Gastroenterol J PMID: 39967304 DOI: 10.1002/ueg2.12682
Biologic therapies have revolutionized Crohn's disease (CD) management, but their high costs pose a significant barrier to access. Biosimilars can provide increased access to treatment because of significant cost-savings. Ustekinumab is a biological drug against interleukin 12-23 that is employed in treating moderate-to-severe CD. As the patent of the reference …
The role of Akkermansia muciniphila in maintaining health: a bibliometric study
Publication Year: 2025 Source: Front Med (Lausanne) PMID: 39967592 DOI: 10.3389/fmed.2025.1484656
BACKGROUND: Akkermansia muciniphila, as a probiotic, is negatively linked to IBD, obesity, and T2DM. The aim of this study was to comprehensively assess the research status of Akkermansia muciniphila over the past decade and explore the relationships between this bacterium and various health-related aspects. METHODS: Tools VOSviewer, Bibliometrix, and CiteSpace …
Unveiling the novel role of circadian rhythms in sepsis and septic shock: unexplored implications for chronotherapy
Publication Year: 2025 Source: Front Endocrinol (Lausanne) PMID: 39968295
Circadian rhythms are critical to coordinating body processes to external environmental cues, such as light and feeding, to ensure efficiency and maintain optimal health. These rhythms are controlled by 'clock' transcription factors, such as Clock, Bmal1, Per1/2, Cry1/2, and Rev-erbs, which are present in almost every tissue. In modern society, …
Thyroid disorders and inflammatory bowel disease: an association present in adults but also in children and adolescents
Publication Year: 2025 Source: Front Endocrinol (Lausanne) PMID: 39968296 DOI: 10.3389/fendo.2025.1425241
Inflammatory bowel diseases (IBD) represent chronic inflammatory multisystemic disorders that primarily involve the gastrointestinal tract. Patients with ulcerative colitis (UC) and Crohn's disease (CD) exhibit a higher prevalence of thyroid disorders compared to the general population. The aim of this review is to summarize the literature on concomitant IBD and …
The Effects of Yoga on the Mental Health of Individuals With Autoimmune Disorders: A Scoping Review
Publication Year: 2025 Source: Cureus PMID: 39968418
Yoga has been explored as a health modality to maintain mental and physical health and as a complementary therapy for managing various medical conditions. It has been most recently researched for its ability to decrease inflammatory markers responsible for various ailments. This opens the door for its potential role as …
RISE-MX, a real-world study of patients with moderate/severe inflammatory bowel disease returning for hospital follow-up in Mexico: baseline demographics and clinical characteristics, treatment and disease status
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 39968532 DOI: 10.1177/17562848251318857
BACKGROUND: Inflammatory bowel disease (IBD) is characterized by periods of remission and relapses, and treatment is based on phenotype, risk factors, and disease severity. Treatments include 5-aminosalicylates (5-ASA), thiopurines, methotrexate, calcineurin inhibitors, corticosteroids (CS), biological therapy (BxT), and, more recently, small molecules. OBJECTIVE: To determine the baseline demographics and clinical …
Virtual chromoendoscopy for the identification of colonic dysplasia in patients with inflammatory bowel disease. A systematic review
Publication Year: 2025 Source: Rev Esp Enferm Dig PMID: 39968657 DOI: 10.17235/reed.2025.9878/2023
Patients with inflammatory bowel disease (IBD) in the colon have a higher risk for colorectal cancer (CRC). Virtual chromoendoscopy (VCE) allows identification and assessment of colonic dysplasia, which might displace dye-based chromoendoscopy (DCE) as the endoscopist's technique of choice for these patients within endoscopic surveillance programs. OBJECTIVE: to analyze the …
Evaluation of fecal neutrophil gelatinase-associated lipocalin levels in childhood inflammatory bowel disease
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 39968866 DOI: 10.1002/jpn3.70015
OBJECTIVES: Inflammatory bowel disease (IBD) is an immune-mediated, chronic, remitting, and relapsing disease. Calprotectin, used in monitoring the disease activity, is expressed from neutrophilic granulocytes during inflammation. Neutrophil gelatinase-associated lipocalin (NGAL) is strongly expressed in both granulocytes and the intestinal epithelial cell layer. The aim of the study was to …
Progressing advanced therapies for inflammatory bowel disease: Current status including dual biologic therapy and discontinuation of biologics
Publication Year: 2025 Source: Expert Rev Gastroenterol Hepatol PMID: 39968880 DOI: 10.1080/17474124.2025.2469832
INTRODUCTION: Advanced therapies (ADT) that encompass biological agents and small molecules have been approved for the treatment of inflammatory bowel disease (IBD), broadening the spectrum of available treatment options. Nevertheless, a substantial proportion of patients fail to achieve satisfactory responses, necessitating surgical intervention. Treatment objectives have evolved beyond clinical remission, …
Pre-clinical enteropathy in healthy soft-coated wheaten terriers
Publication Year: 2025 Source: J Vet Intern Med PMID: 39968924 DOI: 10.1111/jvim.17293
BACKGROUND: Soft-coated wheaten terriers (SCWTs) have a predisposition to the development of protein-losing enteropathy (PLE). Early recognition of disease may improve morbidity and mortality in these and other at-risk dogs. Preclinical inflammatory bowel disease (IBD), characterized by increased intestinal permeability, immune dysregulation and inflammation, and changes to the gut microbial …
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