Research Articles Library
Literature Analysis Tools
Advanced Search
Filter by PMID, year, source, DOI and other criteria
Literature Analysis
Analyze research trends and hotspots
Batch Export
Export search results to Excel/PDF
The Use of Gut Organoids: To Study the Physiology and Disease of the Gut Microbiota
Publication Year: 2025 Source: J Cell Mol Med PMID: 39968926
The intestinal flora has attracted much attention in recent years. An imbalance in the intestinal flora can cause not only intestinal diseases but also cause a variety of parenteral diseases, such as endocrine diseases, nervous system diseases and cardiovascular diseases. Research on the mechanism of disease is likely to be …
Systematic review: severe endoscopic lesions in inflammatory bowel disease
Publication Year: 2025 Source: J Crohns Colitis PMID: 39968931 DOI: 10.1093/ecco-jcc/jjaf029
BACKGROUND: Endoscopy and biopsy are the standard tools for the diagnosis of inflammatory bowel disease (IBD) and the assessment of treatment response. Severe endoscopic lesions (SEL) are commonly observed in IBD, but have been poorly described in the literature. The aim of this review is to provide an overview of …
DIAGNOSIS AND TREATMENT OF SMALL INTESTINAL BACTERIAL OVERGROWTH: AN OFFICIAL POSITION PAPER FROM THE BRAZILIAN FEDERATION OF GASTROENTEROLOGY
Publication Year: 2025 Source: Arq Gastroenterol PMID: 39968993 DOI: 10.1590/S0004-2803.24612024-107
BACKGROUND: Small intestinal bacterial overgrowth (SIBO) is a condition characterized by an abnormal increase in bacterial population in the small intestine, leading to symptoms such as bloating, abdominal pain, distension, diarrhea, and eventually malabsorption. The diagnosis and management of SIBO remain challenging due to overlapping symptoms with other gastrointestinal disorders …
Analytical and clinical considerations of synovial fluid calprotectin in diagnosing periprosthetic joint infections
Publication Year: 2025 Source: Crit Rev Clin Lab Sci PMID: 39969081 DOI: 10.1080/10408363.2025.2463634
Calprotectin is a protein predominantly found in the cytosol of myeloid cells, such as neutrophils and monocytes. Calprotectin has several functions in innate immunity, such as attenuating bacteria, recruiting and activating immune cells, and aiding in the production of pro-inflammatory cytokines and reactive oxygen species. Due to its presence in …
Serum Collagen Biomarkers Are Reflective of Tissue Specific Fibroblasts Associated With Ulcerative Colitis Activity and Treatment Response to Ustekinumab
Publication Year: 2025 Source: United European Gastroenterol J PMID: 39969502
BACKGROUND: There is a need to identify peripheral biomarkers reflective of defined disease associated fibroblasts in Ulcerative Colitis (UC), with the aim of enabling clinical development approaches for novel-stromal-targeted therapeutics for individuals at risk for fibrostenotic complications. Additionally, longitudinal non-invasive biomarkers of tissue remodelling, fibroblast biology and pharmacodynamic measurements are …
First-line anti-TNF agents, ustekinumab and vedolizumab perform similarly in Crohn' disease, but not in ulcerative colitis
Publication Year: 2025 Source: Eur J Gastroenterol Hepatol PMID: 39970039 DOI: 10.1097/MEG.0000000000002940
BACKGROUND: Real-word comparisons between first-line biologicals in inflammatory bowel disease (IBD) are scarce. AIMS: The aim of this study is to compare drug persistence and patient reported outcome-2 (PRO-2) remission rates of first-line biological classes [anti-tumor necrosis factor (TNF) agents vs anti-integrin vedolizumab vs IL-12/23 inhibitor ustekinumab] in real life …
Ustekinumab for ulcerative colitis: a nationwide real-life observational cohort study
Publication Year: 2025 Source: Eur J Gastroenterol Hepatol PMID: 39970041
OBJECTIVE: This nationwide retrospective chart review study assessed ustekinumab treatment persistence and clinical outcomes of ustekinumab treatment in Finnish patients with ulcerative colitis in a real-world setting. METHODS: Data was collected retrospectively until April 2022 from patient charts for all patients with ulcerative colitis who started ustekinumab between September 2019 …
Organophosphate flame retardant triphenyl phosphate (TPhP) induced colonic fibrosis by bringing about epithelial-mesenchymal transition
Publication Year: 2025 Source: Ecotoxicol Environ Saf PMID: 39970497 DOI: 10.1016/j.ecoenv.2025.117913
Intestinal fibrosis is often observed in inflammatory bowel disease (IBD) and seriously affects intestinal health. Our previous study identified that triphenyl phosphate (TPhP), one kind of frequently used organophosphate flame retardants (OPFRs), induced IBD-like features in colon. Herein, we firstly observed extracellular matrix deposition in colon tissues, indicative of appearance …
Rosmarinic acid-chondroitin sulfate nanoconjugate for targeted treatment of ulcerative colitis
Publication Year: 2025 Source: Int J Biol Macromol PMID: 39971022
Rosmarinic acid (RA) is an attractive candidate for ulcerative colitis (UC) application due to its bioactive properties, including antioxidant and anti-inflammatory functions, however, the poor water solubility and on-targeting hamper its therapeutic outcome. Therefore, this work reported the synthesis and preparation of novel water-soluble rosmarinic acid-chondroitin sulfate A (RA-CSA) nanoconjugate, …
Activation of aryl hydrocarbon receptor attenuates intestinal inflammation by enhancing IRF4-mediated macrophage M2 polarization
Publication Year: 2025 Source: Biochim Biophys Acta Mol Basis Dis PMID: 39971258
BACKGROUND: Crohn's disease (CD) is characterized by immune cell dysregulation, with macrophages playing an indisputable role. Macrophages can exhibit opposing polarization under different conditions, resulting in pro- or anti-inflammatory effects. The aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor, is implicated in intestinal inflammation by regulating both innate and adaptive …
Need more literature?
The current database contains 98453 research articles. If you need to search for more literature or perform AI analysis, please use our knowledge acquisition module or explore external literature resources.
External Resources: Access comprehensive literature databases worldwide