Research Articles Library
Literature Analysis Tools
Advanced Search
Filter by PMID, year, source, DOI and other criteria
Literature Analysis
Analyze research trends and hotspots
Batch Export
Export search results to Excel/PDF
Gut microbiome shifts in adolescents after sleeve gastrectomy with increased oral-associated taxa and pro-inflammatory potential
Publication Year: 2025 Source: Gut Microbes PMID: 39971742
Bariatric surgery is highly effective in achieving weight loss in children and adolescents with severe obesity, however the underlying mechanisms are incompletely understood, and gut microbiome changes are unknown. Here, we show that adolescents exhibit significant gut microbiome and metabolome shifts several months after laparoscopic vertical sleeve gastrectomy (VSG), with …
Activated type 17 helper T cells affect tofacitinib treatment outcomes
Publication Year: 2025 Source: Sci Rep PMID: 39971758
The incidence of ulcerative colitis (UC) is on the rise also in Japan. Simultaneously, therapeutic options, including biologics and Janus kinase (JAK) inhibitors, have significantly expanded over the past decade. Although tofacitinib (TOF), one of JAK inhibitors, is a viable option for patients with moderate to severe UC, there is …
Role of Cytochromes P450 in Intestinal Barrier Function: Possible Involvement in the Pathogenesis of Leaky Gut Syndrome
Publication Year: 2025 Source: Dig Dis Sci PMID: 39971825 DOI: 10.1007/s10620-025-08873-8
The intestinal barrier constitutes the largest surface of the human body communicating with the external environment. Alterations affecting elements of intestinal wall may lead to increased intestinal permeability and resulting translocation of bacteria or its components to the bloodstream in the form of the "leaky gut syndrome" (LGS). One of …
Fecal microbiota and genetics in pediatric-onset orofacial granulomatosis and Crohn´s disease
Publication Year: 2025 Source: Sci Rep PMID: 39972069
Orofacial granulomatosis (OFG) is a rare chronic inflammatory condition. It is under debate, whether it is a condition of its own or merely a subtype of Crohn's disease (CD). We aimed to search for markers characteristic of patients with pediatric-onset OFG compared to patients with pediatric-onset CD. We recruited young …
Systematic review of bidirectional interaction between gut microbiome, miRNAs, and human pathologies
Publication Year: 2025 Source: Front Microbiol PMID: 39973938 DOI: 10.3389/fmicb.2025.1540943
MicroRNAs (miRNAs) and the gut microbiome are key regulators of human health, with emerging evidence highlighting their complex, bidirectional interactions in chronic diseases. miRNAs, influence gene expression and can modulate the composition and function of the gut microbiome, impacting metabolic and immune processes. Conversely, the microbiome can affect host miRNA …
The association between perceived social support and self-management behaviors in adolescents and young adults with inflammatory bowel disease: the chain mediating role of basic psychological needs and anxiety/depression
Publication Year: 2025 Source: Front Psychol PMID: 39973951 DOI: 10.3389/fpsyg.2025.1483021
INTRODUCTION: The incidence of inflammatory bowel disease (IBD) has been increasing, with adolescents and young adults being the peak age of onset. Self-management behaviors were demonstrated to enhance remission and quality of life, yet the mechanisms influencing self-management behaviors remained under-explored. Perceived social support is crucial to self-management behaviors, alongside …
A Review of the Current Trends and Future Perspectives of Robots in Colorectal Surgery: What Have We Got Ourselves Into?
Publication Year: 2025 Source: Cureus PMID: 39974228
Robotic colorectal surgery represents a significant advancement in the management of complex colorectal conditions, offering enhanced precision, safety, and improved patient outcomes. It is widely utilised for colorectal cancer, inflammatory bowel disease, diverticular disease, and rectal prolapse, with key benefits such as 3D visualisation, superior dexterity, and precise navigation in …
Diagnostic interval of inflammatory bowel disease in Chinese children and its relationship with growth parameters: a retrospective study
Publication Year: 2025 Source: Front Pediatr PMID: 39974294 DOI: 10.3389/fped.2025.1465694
BACKGROUND: Delayed diagnosis of inflammatory bowel disease (IBD) is common in Europe and North America, with limited research in Asia. We aimed to investigate factors influencing delayed diagnosis of IBD in Chinese children and the impact of delayed diagnosis on growth. METHODS: This was a retrospective study. Clinical data on …
Cannabidiol Targets Colorectal Cancer Cells via Cannabinoid Receptor 2, Independent of Common Mutations
Publication Year: 2025 Source: ACS Pharmacol Transl Sci PMID: 39974647
Cannabidiol (CBD) is a non-neurotoxic, phytocannabinoid from cannabis with reported medicinal properties, including antiepileptic and anti-inflammatory activity. Several in vitro and in vivo studies have shown that CBD has antitumor potential against colorectal cancer (CRC), the third deadliest cancer in the world. However, as different mutations influence the antitumor effects …
Towards painless and productive research relationships: reflections on study design by a researcher with chronic pain for participants with chronic pain
Publication Year: 2025 Source: Front Pain Res (Lausanne) PMID: 39974654
No Abstract
Need more literature?
The current database contains 98453 research articles. If you need to search for more literature or perform AI analysis, please use our knowledge acquisition module or explore external literature resources.
External Resources: Access comprehensive literature databases worldwide