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Development and assessment of an intestinal tri-cellular model to investigate the pro/anti-inflammatory potential of digested foods
Publication Year: 2025 Source: Front Immunol PMID: 39975553 DOI: 10.3389/fimmu.2025.1545261
INTRODUCTION: Immunonutrition, defined as the potential of foods, nutrients and dietary patterns to modulate the immune system activity, has been proposed as a strategy to enhance the immune response in both metabolic and immune-mediated diseases. However, the anti-/pro-inflammatory role of foods and diets is far to be fully ascertained, and …
Interactions between NAD+ metabolism and immune cell infiltration in ulcerative colitis: subtype identification and development of novel diagnostic models
Publication Year: 2025 Source: Front Immunol PMID: 39975557
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory disease of the colonic mucosa with increasing incidence worldwide. Growing evidence highlights the pivotal role of nicotinamide adenine dinucleotide (NAD+) metabolism in UC pathogenesis, prompting our investigation into the subtype-specific molecular underpinnings and diagnostic potential of NAD+ metabolism-related genes (NMRGs). METHODS: Transcriptome …
Human Organ Chips Reveal New Inflammatory Bowel Disease Drivers
Publication Year: 2025 Source: Res Sq PMID: 39975910 DOI: 10.21203/rs.3.rs-5627712/v1
Inflammatory bowel disease (IBD) patients exhibit compromised intestinal barrier function and decreased mucus accumulation, as well as increased inflammation, fibrosis, and cancer risk, with symptoms often being exacerbated in women during pregnancy. Here, we show that these IBD hallmarks can be replicated using human Organ Chips lined by IBD patient-derived …
Characteristics, risk factors, and disease course of musculoskeletal manifestations in patients with inflammatory bowel disease: a prospective longitudinal cohort study
Publication Year: 2025 Source: Eur J Gastroenterol Hepatol PMID: 39975984 DOI: 10.1097/MEG.0000000000002921
BACKGROUND: Musculoskeletal manifestations occur in half of the patients with inflammatory bowel disease (IBD) and contribute to a reduced quality of life (QoL) and increased work disability. We aimed to evaluate the natural disease course, characteristics, and risk factors of musculoskeletal manifestations in patients with IBD. METHODS: We performed a …
Claudin-2 simplifies histological assessment of activity/remission of ulcerative colitis in real-life daily practice
Publication Year: 2025 Source: Eur J Gastroenterol Hepatol PMID: 39975995
OBJECTIVES: Mucosal healing, and in particular histological mucosal healing, represents the new frontier as a treatment goal for inflammatory bowel diseases. However, the assessment of mucosal healing is presently somewhat limited by the numerous pathological scores available, and the lack of a global consensus on how to best assess it. …
The use of oral antibiotic cocktail in medically refractory paediatric acute severe colitis: a case series
Publication Year: 2025 Source: Eur J Gastroenterol Hepatol PMID: 39976007
OBJECTIVE: Paediatric acute severe colitis (ASC) is a life-threatening gastroenterological emergency and a predictor of poor long-term inflammatory bowel disease outcomes. We report our experience with oral antibiotic combination therapy as rescue therapy for children with ASC failing to respond to conventional medical therapy (CMT). METHODS: We analysed data of …
The usefulness of serum leucine-rich alpha-2 glycoprotein as a novel biomarker in monitoring inflammatory bowel disease: a systematic review and meta-analysis
Publication Year: 2025 Source: Eur J Gastroenterol Hepatol PMID: 39976047 DOI: 10.1097/MEG.0000000000002952
Inflammatory bowel disease (IBD) is a condition of unknown origin. It does not have a definite cure and its response to various treatments can be evaluated based on symptom-based measures, invasive procedures, or biomarker levels, highlighting the need for an accurate biomarker. Since C-reactive protein (CRP) and fecal calprotectin have …
Efficacy and safety of tofacitinib for the treatment of moderate-to-severe ulcerative colitis in biologic-naive patients
Publication Year: 2025 Source: Eur J Gastroenterol Hepatol PMID: 39976073
BACKGROUND AND AIMS: Tofacitinib has been approved for the treatment of patients with moderate-to-severe ulcerative colitis independently of prior therapies. We aimed to assess the efficacy and safety of tofacitinib in biologic-naive patients. METHODS: This was a retrospective analysis of prospectively collected data extracted from the notes of patients with …
[Pediatric autoimmune digestive diseases]
Publication Year: 2025 Source: Rev Med Suisse PMID: 39976139
In pediatric gastroenterology and hepatology, autoimmune diseases, such as inflammatory bowel diseases, celiac disease, and autoimmune hepatitis, are challenging for practitioners due to their increasing incidence, high morbidity, and substantial impact on children's quality of life. These conditions share similar pathophysiological mechanisms, including genetic predisposition, the role of the microbiome, …
IgA vasculitis induced by tumor necrosis factor-α antagonists: clinical features, diagnosis and management
Publication Year: 2025 Source: Arch Dermatol Res PMID: 39976811
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