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Novel Transcriptomic Signatures in Fibrostenotic Crohn's Disease: Dysregulated Pathways, Promising Biomarkers, and Putative Therapeutic Targets
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39977234
BACKGROUND: Fibrosis is a common complication in Crohn's disease (CD), often leading to intestinal strictures. This study aims to explore the transcriptomic signature of fibrostenotic ileal CD for a comprehensive characterization of biological and cellular mechanisms underlying intestinal fibrosis. METHODS: Nine CD patients undergoing surgery for fibrotic ileal strictures were …
Impact of Psychosocial and Neurodevelopmental Disorders on Pediatric Ulcerative Colitis: A Single-Center, Retrospective, Observational Study
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39977241
BACKGROUND: This study aimed to evaluate the effects of psychosocial and neurodevelopmental disorders on pediatric ulcerative colitis management. Specifically, the relationships between these disorders and disease severity, as well as treatment strategies, were assessed through a single-center, retrospective, observational study. METHODS: The study included pediatric patients with ulcerative colitis (UC) …
Incidence of uveitis and inflammatory bowel disease in psoriatic disease, and psoriatic disease in uveitis and inflammatory bowel disease
Publication Year: 2025 Source: Rheumatology (Oxford) PMID: 39977376
No Abstract
Addressing the Challenges of Inflammatory Bowel Disease-Primary Sclerosing Cholangitis Treatment: Prognosis Optimization Strategies in the Era of Precision Medicine
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39977391
No Abstract
Noninvasive Detection and Monitoring of the Integrity of the Intestinal Barrier through NIR-II Fluorescence Imaging and Colorimetric Urinalysis
Publication Year: 2025 Source: ACS Appl Mater Interfaces PMID: 39977645
The variation of the integrity of the intestinal barrier is closely related to the occurrence and progression of various diseases, making its accurate detection and monitoring essential to provide reliable information for guiding the refinement of treatment scenarios. Herein, we developed a strategy utilizing glutathione-capped gold clusters (Au-GSH) to achieve …
Flavonoids from sour jujube leaves: Ultrasound-assisted extraction, UPLC-QQQ-MS/MS quantification, and ameliorative effect on DSS-induced ulcerative colitis in mice
Publication Year: 2025 Source: Ultrason Sonochem PMID: 39978127
To valorize sour jujube (Ziziphus acidojujuba) leaves, this work focused on the extraction, quantification, and bioactivity assessment of flavonoids. First, ultrasound-assisted extraction (UAE) was employed to extract total flavonoids from sour jujube leaves (SJL-TF), with the procedure optimized through single-factor design and response surface methodology (RSM). SJL-TF yield reached 48.47 …
Dihydroartemisinin attenuates acetic acid-induced ulcerative colitis in rats: Suppression of inflammation and modulation of NFκβ/TNF-α/RIPK1-mediated necroptosis and apoptosis
Publication Year: 2025 Source: Tissue Cell PMID: 39978210
BACKGROUND: Ulcerative colitis (UC) is an inflammatory bowel disease characterized by the overproduction of reactive oxygen species (ROS) and the release of inflammatory mediators. Dihydroartemisinin (DHA) is a semi-synthetic active metabolite of artemisinin that has anti-inflammatory, antioxidant, and anti-fibrotic properties. OBJECTIVE: This study aimed to assess the therapeutic benefits of …
Beta-hydroxy-beta-methylbutyrate (HMB) ameliorates DSS-induced colitis by inhibiting ERK/NF-κB activation in macrophages
Publication Year: 2025 Source: Phytomedicine PMID: 39978274 DOI: 10.1016/j.phymed.2025.156492
BACKGROUND: beta-Hydroxy beta-Methylbutyrate (HMB), derived from leucine, is known for its role in anti-oxidation and anti-inflammation. But, the application of HMB in IBD treatment is not fully understood, highlighting the requirement for further research. PURPOSE: We aimed to examine the effects of HMB treatment on DSS-induced chronic colitis in mice …
Combotherapies in immune-mediated inflammatory diseases: A study using the Clinical Data Warehouse from Paris Hospitals' Public Assistance
Publication Year: 2025 Source: Semin Arthritis Rheum PMID: 39978288
BACKGROUND: The combination of different biological and targeted synthetic DMARDs (i.e., combotherapy) has recently emerged in the management of immune-mediated inflammatory diseases (IMID). However, real-life data across specialities and prognostic factors related to combotherapy are lacking. METHODS: Multicenter observational study conducted using the Clinical Data Warehouse from Paris Hospitals' Public …
Synergistic role of gut-microbial L-ornithine in enhancing ustekinumab efficacy for Crohn's disease
Publication Year: 2025 Source: Cell Metab PMID: 39978335 DOI: 10.1016/j.cmet.2025.01.007
The role of the intestinal microbiome in Crohn's disease (CD) treatment remains poorly understood. This study investigates microbe-host interactions in CD patients undergoing ustekinumab (UST) therapy. Fecal metagenome, metabolome, and host transcriptome data from 85 CD patients were analyzed using multi-omics integration and mediation analysis. Our findings reveal significant microbiome-metabolite-host …
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