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Symptom Resolution and Meaningful Improvement in Quality of Life With Risankizumab in Patients With Ulcerative Colitis: Post Hoc Analysis of the Randomized INSPIRE and COMMAND Studies
Publication Year: 2025 Source: Am J Gastroenterol PMID: 40094309
INTRODUCTION: Patients with ulcerative colitis (UC) experience disruptive symptoms that can impair quality of life (QoL). This study examined the effect of risankizumab (RZB) induction and maintenance treatment on symptom resolution and health-related QoL (HRQoL) outcomes. METHODS: For the 12-week induction, patients were randomized to intravenous (IV) RZB 1,200 mg …
Phellinus linteus (Agaricomycetes) Polysaccharides Ameliorate Inflammatory Injury in H2O2-Induced Caco-2 Cells and DSS-Induced Ulcerative Colitis Mice
Publication Year: 2025 Source: Int J Med Mushrooms PMID: 40094337
Phellinus linteus (Agaricomycetes) is a valuable medicinal mushroom traditionally used as a food supplement and medicinal ingredient. Polysaccharides of Ph. linteus (PLP) possess strong anti-inflammatory effects and gut microbiota modulating properties. However, the mechanism of its efficacy in ulcerative colitis (UC) remains unclear. This study utilized 1mM H2O2 to induce …
Cumulative incidence and prevalence of perianal diseases in patients with inflammatory bowel disease and in the population: a nationwide Swedish study
Publication Year: 2025 Source: Scand J Gastroenterol PMID: 40094394 DOI: 10.1080/00365521.2025.2476669
BACKGROUND: Perianal diseases are more common in patients with Crohn's disease (CD) than in the general population, but data are scarce in other inflammatory bowel disease (IBD) subtypes. METHOD: Using data from the Swedish National Patient Register (NPR) and SWIBREG, the national quality register for IBD, we estimated the cumulative …
Exploring the Therapeutic Potential of Medicinal Plants in the Context of Gastrointestinal Health: A Review
Publication Year: 2025 Source: Plants (Basel) PMID: 40094542
Medicinal plants represent promising sources for the treatment of gastrointestinal disorders because of their abundance in bioactive compounds with therapeutic properties. Throughout history, various plant species have been used to alleviate digestive ailments, and studies have revealed the presence of metabolites with anti-inflammatory, antibacterial, antiviral, antiparasitic, antidiarrheal, antioxidant, and anticancer …
VCAM-1 as a common biomarker in inflammatory bowel disease and colorectal cancer: unveiling the dual anti-inflammatory and anti-cancer capacities of anti-VCAM-1 therapies
Publication Year: 2025 Source: Cancer Metastasis Rev PMID: 40095109 DOI: 10.1007/s10555-025-10258-2
Vascular cell adhesion molecule (VCAM)-1 has garnered significant research attention due to its potential as a disease biomarker and drug target across several inflammatory pathologies-including atherosclerosis, asthma, rheumatoid arthritis, and inflammatory bowel disease (IBD). The VCAM-1 protein has also been noted for its functional involvement in cancer metastasis and drug …
Paradigm Shift in Inflammatory Bowel Disease Management: Precision Medicine, Artificial Intelligence, and Emerging Therapies
Publication Year: 2025 Source: J Clin Med PMID: 40095460 DOI: 10.3390/jcm14051536
Inflammatory bowel disease (IBD) management stands at the cusp of a transformative era, with recent breakthroughs heralding a paradigm shift in treatment strategies. Traditionally, IBD therapeutics revolved around immunosuppressants, but the landscape has evolved significantly. Recent approvals of etrasimod, upadacitinib, mirikizumab, and risankizumab have introduced novel mechanisms of action, offering …
Are Vitamin D Levels Related to Sarcopenia in Children with Inflammatory Bowel Disease?
Publication Year: 2025 Source: J Clin Med PMID: 40095479 DOI: 10.3390/jcm14051548
Background: Data on the impacts of vitamin D deficiency on sarcopenia in pediatric patients with inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are lacking. We aimed to investigate the relationships between vitamin D levels and sarcopenia in patients with newly diagnosed IBD. Methods: A cross-sectional, …
Accelerating Earlier Access to Anti-TNF-α Agents with Biosimilar Medicines in the Management of Inflammatory Bowel Disease
Publication Year: 2025 Source: J Clin Med PMID: 40095484 DOI: 10.3390/jcm14051561
Data indicate that earlier initiation of anti-tumor necrosis factor alpha (anti-TNF-alpha) biologic medicines may prevent progression to irreversible bowel damage and improve outcomes for patients with inflammatory bowel disease (IBD), particularly Crohn's disease. However, the high cost of such therapies may restrict access and prevent timely treatment of IBD. Biosimilar …
Preoperative Optimization for Elective Surgery in Crohn's Disease: A Narrative Review
Publication Year: 2025 Source: J Clin Med PMID: 40095509
Crohn's disease is a chronic inflammatory bowel disease and, despite an increase in the available drug treatments, many patients will still require surgery at some point in their disease course. Stricturing and penetrating phenotypes of Crohn's disease are less likely to respond to our current medical treatment and, therefore, surgical …
Joint Manifestations in Inflammatory Bowel Diseases, "Red Flags" for the Early Recognition and Management of Related Arthropathies: A Narrative Review
Publication Year: 2025 Source: J Clin Med PMID: 40095525 DOI: 10.3390/jcm14051558
Inflammatory bowel diseases (IBDs), including Crohn's disease and ulcerative colitis, frequently present with extra-intestinal manifestations. Virtually all patients with IBD could be at risk for developing inflammatory arthropathies within the spectrum of spondyloarthritis (SpA). In this context, prompt recognition of musculoskeletal "red flags" (lower back pain, dactylitis, enthesitis, swelling of …
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