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Management of Fatigue in Inflammatory Bowel Disease: A Narrative Review
Publication Year: 2025 Source: Int J Gen Med PMID: 40092455 DOI: 10.2147/IJGM.S502142
Inflammatory bowel disease (IBD) encompasses chronic inflammatory conditions of the digestive tract, including Crohn's disease and ulcerative colitis. Fatigue is one of the common and important extraintestinal symptoms in IBD patients, which significantly affects the patient's ability to work, daily life, social activities, emotional state, and cognitive function. Although the …
Multimodal Lifestyle Intervention Improves Fatigue in Quiescent Inflammatory Bowel Disease: A Controlled Study
Publication Year: 2025 Source: Crohns Colitis 360 PMID: 40092635 DOI: 10.1093/crocol/otaf009
BACKGROUND: Lifestyle factors are significant contributors to fatigue, affecting ~45% of patients with inflammatory bowel disease (IBD). Hence, we evaluated the effect of a multimodal lifestyle intervention on fatigue in patients with IBD. METHODS: Patients with quiescent IBD were enrolled in this multicenter, non-randomized, controlled interventional study. The intervention group …
Development of a Burden Scale for Colonoscopy Experienced by Patients with Inflammatory Bowel Disease
Publication Year: 2025 Source: Inflamm Intest Dis PMID: 40092636 DOI: 10.1159/000543686
INTRODUCTION: This study aimed to develop and validate a burden scale for colonoscopy-specific experiences among patients with inflammatory bowel disease (IBD) and to assess its reliability and validity. METHODS: Building upon previous research on patient experiences and perceptions of colonoscopy, a 33-item pain scale was developed. Content validity was assessed …
Kinesin family member 14 expression and its clinical implications in colorectal cancer
Publication Year: 2025 Source: World J Gastrointest Oncol PMID: 40092935
BACKGROUND: Colorectal cancer (CRC) is the third most common cancer globally, causing over 900000 deaths annually. Risk factors include aging, diet, obesity, sedentary lifestyle, tobacco use, genetic predisposition, and inflammatory bowel disease. Despite current treatments, survival rates for advanced CRC remain low, highlighting the need for better therapeutic strategies. AIM: …
Inflammation-fibrosis interplay in inflammatory bowel disease: mechanisms, progression, and therapeutic strategies
Publication Year: 2025 Source: Front Pharmacol PMID: 40093318 DOI: 10.3389/fphar.2025.1530797
BACKGROUND: The incidence of intestinal fibrosis in Inflammatory bowel disease has increased in recent years, and the repair process is complex, leading to substantial economic and social burdens. Therefore, understanding the pathogenesis of intestinal fibrosis and exploring potential therapeutic agents is crucial. PURPOSE: This article reviews the pathogenesis of IBD-related …
The global research of artificial intelligence on inflammatory bowel disease: A bibliometric analysis
Publication Year: 2025 Source: Digit Health PMID: 40093709 DOI: 10.1177/20552076251326217
AIMS: This study aimed to evaluate the related research on artificial intelligence (AI) in inflammatory bowel disease (IBD) through bibliometrics analysis and identified the research basis, current hotspots, and future development. METHODS: The related literature was acquired from the Web of Science Core Collection (WoSCC) on 31 December 2024. Co-occurrence …
Exploring the Shared Diagnostic Genes in IBD and Psoriasis through Bioinformatics and Experimental Assays
Publication Year: 2025 Source: Int J Med Sci PMID: 40093802 DOI: 10.7150/ijms.107018
Background: Inflammatory bowel disease (IBD) is a persistent, non-specific inflammation affecting the intestines. Psoriasis is a long-lasting inflammatory disorder of the skin. There is a comorbidity correlation between IBD and psoriasis, but the specific pathogenesis of the comorbidity is unclear. Materials and methods: In this study, we analyzed datasets sourced …
Engineered Probiotic-Based Biomaterials for Inflammatory Bowel Disease Treatment
Publication Year: 2025 Source: Theranostics PMID: 40093907 DOI: 10.7150/thno.103983
Inflammatory bowel disease (IBD) is a chronic condition affecting the intestines, marked by immune-mediated inflammation. This disease is known for its recurrent nature and the challenges it presents in treatment. Recently, probiotic have gained attention as a promising alternative to traditional small molecular drugs and monoclonal antibody chemotherapies for IBD. …
Integrated Analysis of Ferroptosis and Immune Infiltration in Ulcerative Colitis Based on Bioinformatics
Publication Year: 2025 Source: J Inflamm Res PMID: 40093944 DOI: 10.2147/JIR.S501651
INTRODUCTION: Ulcerative colitis (UC) is an inflammatory bowel disease influenced by genetic, immune, and environmental factors. This study investigates the link between ferroptosis, a cell death process related to oxidative stress and iron metabolism, and immune infiltration in UC. MATERIALS AND METHODS: We analyzed UC patient transcription data from the …
Human colitis-associated colorectal carcinoma progression is accompanied by dysbiosis with enriched pathobionts
Publication Year: 2025 Source: Gut Microbes PMID: 40094201 DOI: 10.1080/19490976.2025.2479774
Dysbiosis and pathobionts contribute to inflammation and the risk of colitis-associated carcinoma (CAC) in animal models, but their roles in humans with this uncommon disease are unknown. We identified microbiome differences in human CAC compared with longstanding inflammatory bowel disease (IBD) and sporadic colorectal carcinoma (CRC). Twenty-four CAC resections were …
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