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Early predictors of induction of remission with exclusive enteral nutrition in children with Crohn's disease
Publication Year: 2025 Source: BMC Pediatr PMID: 40097971 DOI: 10.1186/s12887-025-05497-9
BACKGROUND: Exclusive enteral nutrition (EEN) is recommended as first-line therapy for children with mild to moderate Crohn's disease (CD), given its effectiveness in inducing clinical remission (CR) and promoting mucosal healing (MH). However, the identification of reliable early predictors of EEN response remains an area requiring further investigation. METHODS: Patients …
Long-term safety of fecal microbiota transplantation in Chinese children from 2013 to 2023: a single-center retrospective study
Publication Year: 2025 Source: BMC Microbiol PMID: 40098090 DOI: 10.1186/s12866-025-03858-z
BACKGROUND: The gut microbiome plays a vital role in influencing various health conditions. Fecal Microbiota Transplantation (FMT) has emerged as a rapid, safe, and effective method for modifying the microbiome. However, there is a lack of long-term safety data regarding FMT in children. This study presents the largest single-center analysis …
Editorial: Can We Prevent Inflammatory Bowel Disease?
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40098162
No Abstract
Editorial: Can We Prevent Inflammatory Bowel Disease? Authors' Reply
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40098193
No Abstract
The Impact of Setons on Perianal Fistula Outcomes in Patients With Crohn's Disease Treated With Anti-TNF Therapy: A Multicentre Study
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40098436 DOI: 10.1111/apt.70081
BACKGROUND AND AIMS: We aimed to assess the impact of setons on perianal fistula outcomes in patients with perianal fistulising Crohn's disease (PFCD) treated with anti-TNF therapy. METHODS: We included patients treated with their first anti-TNF therapy for PFCD after undergoing a pelvic MRI between 2005 and 2022 from 6 …
Colorectal Polyps in Young Patients Undergoing Colonoscopy
Publication Year: 2025 Source: J Nepal Health Res Counc PMID: 40098510
BACKGROUND: More than 10 % of colorectal carcinoma occur in patients less than 50 years. Progression of a colorectal polyp to carcinoma may take 5 to 20 years. Implementing screening guidelines and removing such polyps would reduce the progression into carcinoma. The aim of the study was to find the …
Rediscovering histology - the application of artificial intelligence in inflammatory bowel disease histologic assessment
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 40098604 DOI: 10.1177/17562848251325525
Integrating artificial intelligence (AI) into histologic disease assessment is transforming the management of inflammatory bowel disease (IBD). AI-aided histology enables precise, objective evaluations of disease activity by analysing whole-slide images, facilitating accurate predictions of histologic remission (HR) in ulcerative colitis and Crohn's disease. Additionally, AI shows promise in predicting adverse …
Ileal Pouch Cancer Detected More than 30 Years after Restorative Proctocolectomy for Ulcerative Colitis
Publication Year: 2025 Source: Surg Case Rep PMID: 40098733
INTRODUCTION: The standard surgical treatment for ulcerative colitis (UC) is proctocolectomy with hand-sewn ileoanal pouch anastomosis (hand-sewn IPAA) or stapled ileal pouch anastomosis (stapled IPAA). The occurrence of cancer in the ileal pouch after surgery for UC is rare, and a consensus on surveillance for ileal pouch cancer has not …
Editorial: The role of gut microbiota-gut-brain axis in inflammatory bowel disease
Publication Year: 2025 Source: Front Med (Lausanne) PMID: 40098934
No Abstract
High Smad7 marks inflammation in patients with chronic pouchitis
Publication Year: 2025 Source: Front Immunol PMID: 40098948 DOI: 10.3389/fimmu.2025.1549193
BACKGROUND AND AIM: Patients with ulcerative colitis (UC) undergoing colectomy with ileal-anal pouch anastomosis can develop chronic pouchitis (CP). Since treatment options are very limited for patients with CP, identification of factors/mechanisms that amplify the CP-associated inflammatory response could help develop novel treatments. We here assessed the expression of Smad7, …
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