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A break in the line: anastomotic leak triggered by a traumatic fall
Publication Year: 2025 Source: J Surg Case Rep PMID: 40099012 DOI: 10.1093/jscr/rjaf125
Anastomotic leak is a well-documented complication of anterior resection, a procedure commonly performed for colorectal carcinoma or inflammatory bowel disease (IBD). Multiple factors contribute to anastomotic leaks, often related to surgical technique or impaired bowel healing. However, blunt trauma or physical injury has not been widely recognised as a risk …
Targeting CD4+ T cells through gut microbiota: therapeutic potential of traditional Chinese medicine in inflammatory bowel disease
Publication Year: 2025 Source: Front Cell Infect Microbiol PMID: 40099014 DOI: 10.3389/fcimb.2025.1557331
Inflammatory Bowel Disease (IBD) is an autoimmune disease characterized by chronic relapsing inflammation of the intestinal tract. Gut microbiota (GM) and CD4(+)T cells are important in the development of IBD. A lot of studies have shown that GM and their metabolites like short-chain fatty acids, bile acids and tryptophan can …
A Case of Pyoderma Gangrenosum in a 40-Year-Old Male Patient: A Challenging Diagnosis
Publication Year: 2025 Source: Cureus PMID: 40099083
Pyoderma gangrenosum (PG) is a rare, immune-mediated neutrophilic dermatosis, presenting with painful ulcerative skin lesions. These lesions often start as pustules on an erythematous base, progressing to large ulcers with purulent edges. Diagnosing PG can be challenging, as it lacks definitive tests and requires exclusion of other conditions, including infections …
Diffuse vulvar papules in a patient with Crohn's disease
Publication Year: 2025 Source: JAAD Case Rep PMID: 40099177
No Abstract
The potential roles of gut microbiome in porto-sinusoidal vascular disease: an under-researched crossroad
Publication Year: 2025 Source: Front Microbiol PMID: 40099185
Accumulating evidence indicates that patients with liver diseases exhibit distinct microbiological profiles, which can be attributed to the bidirectional relationship of the gut-liver axis. Porto-sinusoidal vascular disease (PSVD) has recently been introduced to describe a group of vascular diseases of the liver, involving the portal venules and sinusoids. Although the …
ITGAX promotes Th17-cell differentiation and drives pathogenesis in pediatric ulcerative colitis
Publication Year: 2025 Source: Histol Histopathol PMID: 40099533
BACKGROUND: Pediatric ulcerative colitis (UC) is an inflammatory bowel disease characterized by dysregulated immune responses and intestinal inflammation, often more severe than adult-onset UC. Th17 cells play a crucial role in UC pathogenesis but the mechanisms regulating their differentiation and recruitment in pediatric UC remain incompletely understood. METHODS: Transcriptomic analysis …
Severe myelosuppression and alopecia after thiopurine initiation in a patient with NUDT15 deficiency
Publication Year: 2025 Source: Br J Clin Pharmacol PMID: 40099566
Thiopurines are a class of immunosuppressant and antineoplastic agents. They are widely used in the treatment of inflammatory bowel disease, haematological malignancies and autoimmune diseases, but can cause significant toxicity. Inherited gene mutations are now recognized as independent risk factors for severe adverse drug reactions to thiopurines even at 10-fold …
Correction to: IBD Across the Ages－A Journey Together
Publication Year: 2025 Source: J Crohns Colitis PMID: 40099654 DOI: 10.1093/ecco-jcc/jjaf035
No Abstract
Forsythiaside A Alleviates Ulcerative Colitis and Inhibits Neutrophil Extracellular Traps Formation in the Mice
Publication Year: 2025 Source: Phytother Res PMID: 40099671
Forsythiaside A (FA), the primary compound found in Forsythia suspensa (Thunb.) Vahl, has demonstrated various pharmacological effects, but its impact on ulcerative colitis (UC) is underexplored. Our study examined the distribution of FA in different parts of the gastrointestinal tracts and its therapeutic effects on UC, along with the underlying …
Low Incidence of Varicella in Pediatric Patients With Inflammatory Bowel Disease
Publication Year: 2025 Source: Am J Gastroenterol PMID: 40099768 DOI: 10.14309/ajg.0000000000003418
INTRODUCTION: Immune-modifying therapies in pediatric inflammatory bowel disease (IBD) increase infection risks, including varicella. METHODS: Using Optum's deidentified Clinformatics Data Mart Database, a nationwide US commercial insurance claims database (2007-2022), we conducted a retrospective study of 5,368 patients with IBD aged 21 years or younger matched to a non-IBD cohort. …
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