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Epidemiology, pathogenesis, diagnosis, and treatment of inflammatory bowel disease: Insights from the past two years
Publication Year: 2025 Source: Chin Med J (Engl) PMID: 39994836 DOI: 10.1097/CM9.0000000000003542
Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is a chronic inflammation of the gastrointestinal tract with unknown etiology. The cause of IBD is widely considered multifactorial, with prevailing hypotheses suggesting that the microbiome and various environmental factors contribute to inappropriate activation of the mucosal immune system in …
Unraveling the microbial mysteries: gut microbiota's role in ulcerative colitis
Publication Year: 2025 Source: Front Nutr PMID: 39996003
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by persistent inflammation of the colon. Recent research has highlighted the significant role of gut microbiota in the pathogenesis and treatment of UC. This review aims to provide a comprehensive overview of the current understanding of the relationship between gut …
Artificial intelligence to revolutionize IBD clinical trials: a comprehensive review
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 39996136 DOI: 10.1177/17562848251321915
Integrating artificial intelligence (AI) into clinical trials for inflammatory bowel disease (IBD) has potential to be transformative to the field. This article explores how AI-driven technologies, including machine learning (ML), natural language processing, and predictive analytics, have the potential to enhance important aspects of IBD trials-from patient recruitment and trial …
Decade-Long Trends in Hospitalization, Outcomes, and Emergency Department Visits for Inflammatory Bowel Diseases in the United States, 2010 to 2020
Publication Year: 2025 Source: Cureus PMID: 39996174 DOI: 10.7759/cureus.77941
Background Data on trends in inflammatory bowel disease (IBD) hospitalizations in the literature are sparse and conflicting. This study evaluated trends in hospitalization and emergency department (ED) visits for IBD between 2010 and 2020 using large data from the United States national inpatient and emergency department sample databases. Methods We …
Development and Validation of the Ileoanal Pouch Syndrome Distress Index
Publication Year: 2025 Source: Ann Surg PMID: 39996315
OBJECTIVE: To design and validate a questionnaire-based scoring system that measures distress and quality of life implications related to specific bowel function symptoms and consequences. SUMMARY OF BACKGROUND DATA: The Patient Reported Outcomes after Pouch Surgery Delphi consensus study identified symptoms and consequences that were utilized to previously create a …
Reasons for (Not) Seeking Care for Fatigue and Care Needs Among Patients With Inflammatory Bowel Disease: A Qualitative Interview Study
Publication Year: 2025 Source: J Adv Nurs PMID: 39996394 DOI: 10.1111/jan.16837
AIMS: To explore reasons why patients with inflammatory bowel disease (IBD) do (not) engage in fatigue-related care and their care needs. DESIGN: A qualitative interview study, using a phenomenological methodological approach. METHODS: We included 16 fatigued patients with IBD in remission. Data were collected between December 2021 and March 2022, …
Inflammatory Bowel Disease Following IL-17 Inhibitor Exposure for Psoriatic Disease and Hidradenitis Suppurativa: A Systematic Review
Publication Year: 2025 Source: J Cutan Med Surg PMID: 39996438
No Abstract
Editorial: Surveillance Colonoscopy for Detection of Neoplasia in Inflammatory Bowel Disease-Is Dye-Based Chromoendoscopy Always the Final Answer? Authors' Reply
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 39996560
No Abstract
Editorial: Surveillance Colonoscopy for Detection of Neoplasia in Inflammatory Bowel Disease-Is Dye-Based Chromoendoscopy Always the Final Answer?
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 39996565
No Abstract
In Vitro Inhibition of Endoplasmic Reticulum Stress: A Promising Therapeutic Strategy for Patients with Crohn's Disease
Publication Year: 2025 Source: Cells PMID: 39996742
BACKGROUND: Crohn's disease (CD) is an inflammatory bowel disease marked by an abnormal immune response and excessive pro-inflammatory cytokines, leading to impaired protein processing and endoplasmic reticulum (ER) stress. This stress, caused by the accumulation of misfolded proteins, triggers the unfolded protein response (UPR) through IRE1/Xbp-1, PERK/eIF2alpha, and ATF6 pathways, …
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