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Mesalazine alleviated the symptoms of spontaneous colitis in interleukin-10 knockout mice by regulating the STAT3/NF-κB signaling pathway
Publication Year: 2025 Source: World J Gastroenterol PMID: 39991681
BACKGROUND: Excessive endoplasmic reticulum (ER) stress in intestinal epithelial cells can lead to damage to the intestinal mucosal barrier, activate the signal transducer and activator of transcription 3 (STAT3)/nuclear factor kappa B (NF-kappaB) signaling pathway, and exacerbate the inflammatory response, thus participating in the pathogenesis of ulcerative colitis (UC). Mesalazine …
Complete genome sequence of an enterotoxigenic Bacteroides fragilis strain 86-5443-2-2 from a piglet
Publication Year: 2025 Source: Microbiol Resour Announc PMID: 39992140
This study presents the genome sequence of Bacteroides fragilis strain 86-5443-2-2, isolated from a piglet. The genome of this strain forms a single contig spanning 5.4 million base pairs with a 43.5% GC content and 4,480 genes. Notably, this bacterium possesses two copies of a pathogenic island capable of producing …
Efficacy of Dietary Supplementation in the Relief of Inflammatory Bowel Disease: A Systematic Review of Animal Studies
Publication Year: 2025 Source: Nutr Rev PMID: 39992299 DOI: 10.1093/nutrit/nuae224
CONTEXT: Supplementation with dietary components is a promising approach for the treatment of inflammatory bowel disease (IBD). OBJECTIVE: The aim was to examine the effects of dietary supplements on experimental animal models of IBD. DATA SOURCES: Articles were selected from 2016 to 2021 and from specific databases (PubMed, Embase, and …
Very long-term remission in behcet's disease following withdrawal of anti-TNF treatment exceeds relapses: a reappraisal of an outcome study
Publication Year: 2025 Source: Rheumatol Int PMID: 39992459
BACKGROUND: Introduction of anti-TNF treatment has greatly improved prognosis of Behcet's disease (BD). Withdrawal of anti-TNF treatment in chronic inflammatory arthritis or bowel disease has been associated with sustained remission in subsets of patients. Herein, we examined the probability of very long-term quiescence after withdrawal of TNF inhibitors in BD. …
Enrichment of rare CFTR variants in Finnish patients with congenital chloride diarrhea
Publication Year: 2025 Source: PLoS One PMID: 39992989 DOI: 10.1371/journal.pone.0318249
OBJECTIVE: The autosomal recessive disease congenital chloride diarrhea (CLD), caused by loss-of-function mutations in the solute carrier family 26 member 3 (SLC26A3) gene, shows association with inflammatory bowel disease (IBD). However, it is unclear whether IBD risk is associated with genetic or immune signatures. SLC26A3 interacts with several ion transporters …
Preoperative Oral Antibiotics Preparation is Associated With Improved 30-day Outcomes in Elective Colectomy for Ulcerative Colitis
Publication Year: 2025 Source: Am Surg PMID: 39993317
BackgroundUlcerative colitis (UC) is characterized by colonic involvement, where the 10-year risk of colectomy remains high at about 20%. The use of preoperative oral antibiotic preparation (OAP) in colectomy remains a subject of debate and there was limited evidence for UC patients. This study aimed to retrospectively investigate the relationship …
Gancao Xiexin decoction attenuated experimental colitis through suppressing ACSL4-mediated ferroptosis
Publication Year: 2025 Source: J Ethnopharmacol PMID: 39993549
ETHNOPHARMACOLOGICAL RELEVANCE: The Gancao Xiexin decoction (GCXXD), comprising Glycyrrhiza glabra L., Pinellia ternata (Thunb.) Makino, Scutellaria baicalensis Georgi, Zingiber officinale Roscoe, Panax ginseng C.A.Mey. , Coptis chinensis Franch. , Ziziphus jujuba Mill. , represents a traditional Chinese medicinal formulation utilized for the treatment of ulcerative colitis (UC). Nevertheless, the potential …
Bulk and Single-Cell Transcriptomic Reveals Shared Key Genes and Patterns of Immune Dysregulation in Both Intestinal Inflammatory Disease and Sepsis
Publication Year: 2025 Source: J Cell Mol Med PMID: 39993996 DOI: 10.1111/jcmm.70415
Inflammatory bowel disease (IBD) and Sepsis are both characterised by immune dysregulation. Notably, IBD is a factor in the increase in septic infections. However, these two conditions' shared molecular and pathophysiological mechanisms remain unclear. We used 'limma' and 'WGCNA' analyses to identify common DEGs between these two conditions. Single-cell RNA …
Spleen volume in relation to ulcerative colitis and Crohn's disease: a Mendelian randomization study
Publication Year: 2025 Source: Sci Rep PMID: 39994250 DOI: 10.1038/s41598-025-90104-1
Prior research has established the significance of spleen volume (SV) in the pathogenesis and advancement of ulcerative colitis (UC) and Crohn's disease (CD). Nevertheless, these investigations are predominantly observational, thereby leaving their causal associations ambiguous. Moreover, the breadth of existing research is constrained by various uncontrollable variables in clinical settings. …
Glaucocalyxin A alleviates ulcerative colitis by inhibiting PI3K/AKT/mTOR signaling
Publication Year: 2025 Source: Sci Rep PMID: 39994449 DOI: 10.1038/s41598-025-91358-5
Isodon japonicus (Burm.f.) Hara var. glaucocalyx (Maxim.) Hara is a herbaceous perennial plant. Historically, it has often been used to treat dysentery and other diseases, indicating its potential efficacy in the treatment of inflammatory conditions affecting the intestines. Glaucocalyxin A (GLA) is a diterpenoid isolated from I. japonicus; recent studies …
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