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Extended mesenteric resection reduces the rate of surgical recurrence in Crohn's disease: a systematic review and meta-analysis
Publication Year: 2025 Source: Int J Colorectal Dis PMID: 39998692
PURPOSE: Mesenteric resection in Crohn's disease (CD) is still controversial and under discussion. We performed a meta-analysis to assess recurrence rates and operative-related morbidity based on the extent of mesenteric resection. METHODS: A comprehensive literature research was conducted until November 2024 using PubMed (Medline), the Cochrane Central trials register, and …
Small bowel vasculitis? what a gastroenterologist should know - from diagnosis to management
Publication Year: 2025 Source: Curr Opin Gastroenterol PMID: 39998849
PURPOSE OF REVIEW: This article provides gastroenterologists with an overview of small bowel involvement in systemic vasculitis. Though various vasculitides can impact the small bowel, we highlight those with a more frequent and clinically significant GI involvement. RECENT FINDINGS: Recent advances, including increased accessibility to cross-sectional imaging, capsule endoscopy and …
Small bowel ultrasound: friend or foe?
Publication Year: 2025 Source: Curr Opin Gastroenterol PMID: 39998917
PURPOSE OF REVIEW: Crohn's disease (CD), requires accurate diagnosis and regular monitoring to manage disease activity, prevent complications, and improve outcomes. Intestinal ultrasound (IUS) has emerged as a noninvasive, real-time imaging modality, offering a valuable alternative to traditional diagnostic techniques such as magnetic resonance enterography (MRE), endoscopy and capsule endoscopy …
Personalized nutrition studies of human gut microbiome-polyphenol interactions utilizing continuous multistaged in vitro fermentation models-a narrative review
Publication Year: 2025 Source: Nutr Res PMID: 39999639
The gut microbiota, a complex community of microorganisms primarily inhabiting the human large intestine, plays a crucial role in human health. Gut dysbiosis, characterized by an imbalance in gut bacterial populations, has been increasingly recognized as a significant factor in the pathogenesis of metabolic diseases such as type 2 diabetes, …
Gut Microbiome Dysbiosis and Inflammatory Bowel Disease Complement Each Other
Publication Year: 2025 Source: Dig Dis PMID: 39999800 DOI: 10.1159/000544771
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract. The worldwide increase in the incidence of IBD imposes a significant economic burden on patients and communities. Recently, numerous studies have shown that disruption of the balance between the host and microbes, known as dysbiosis, is …
Kinetic Redox Shotgun Proteomics Reveals Specific Lipopolysaccharide Effects on Intestinal Epithelial Cells, Mitigated by a Mn Superoxide Dismutase Mimic
Publication Year: 2025 Source: Angew Chem Int Ed Engl PMID: 40000394 DOI: 10.1002/anie.202422644
Overproduction of reactive oxygen species and antioxidant superoxide dismutases (SOD1, SOD2) dysregulation contribute to chronic inflammation such as generated in inflammatory bowel diseases (IBD). A kinetic redox shotgun proteomic strategy (OcSILAC for Oxidized cysteine Stable Isotope Labelling by Amino acids in Cell culture) was used to explore the lipopolysaccharide (LPS) …
Role of Peripheral NLRP3 Inflammasome in Cognitive Impairments: Insights of Non-central Factors
Publication Year: 2025 Source: Mol Neurobiol PMID: 40000575
Cognitive impairments are common clinical manifestation of Alzheimer's disease, vascular dementia, type 2 diabetes mellitus, and autoimmune diseases. Emerging evidence has suggested a strong correlation between peripheral chronic inflammation and cognitive impairments. For example, nearly 40% of individuals with inflammatory bowel disease also suffer from cognitive impairments. In this condition, …
LMO7 drives profibrotic fibroblast polarization and pulmonary fibrosis in mice through TGF-β signalling
Publication Year: 2025 Source: Acta Pharmacol Sin PMID: 40000880
Idiopathic pulmonary fibrosis (IPF) is a progressive lethal disease. Profibrotic fibroblast polarization during wound healing is one of the main causes of IPF, and the molecular mechanisms involved have yet to be fully determined. LIM domain-only protein 7 (LMO7), which acts as an E3 ubiquitin ligase, is highly expressed in …
Risk of stroke in patients with inflammatory bowel disease: a systematic review and meta-analysis
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40000943 DOI: 10.1186/s12876-025-03702-8
BACKGROUND: Current studies suggest a potential link between inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), and cardiovascular diseases, such as stroke. This study aimed to assess the risk of stroke in IBD patients compared to general population. METHODS: Systematic search was done in PubMed, Embase, …
Application of finite mixture models to explore subpopulations in Crohn's disease patients
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40000949 DOI: 10.1186/s12876-025-03675-8
BACKGROUND: Inflammatory bowel disease (IBD) commonly refers to ulcerative colitis (UC) and Crohn disease (CD), which are chronic inflammatory diseases of the gastrointestinal (GI) tract of unknown etiology. This study has been conducted to examine whether there are different components in the data, and if these components related to the …
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