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Machine learning for temporary stoma after intestinal resection in surgical decision-making of Crohn's disease
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40000985
BACKGROUND: Crohn's disease (CD) often necessitates surgical intervention, with temporary stoma creation after intestinal resection (IR) being a crucial decision. This study aimed to construct novel models based on machine learning (ML) to predict temporary stoma formation after IR for CD. METHODS: Patient data who underwent IR for CD at …
Dual Therapy in Inflammatory Bowel Disease
Publication Year: 2025 Source: Biomolecules PMID: 40001525 DOI: 10.3390/biom15020222
Inflammatory bowel diseases (IBDs), including ulcerative colitis (UC) and Crohn's disease (CD), are chronic and complex autoimmune conditions. Despite the advancements in biologics and small molecules, the therapeutic ceiling persists, posing significant treatment challenges and contributing to the concept of difficult-to-treat IBD. Dual-targeted therapy (DTT), combining two biologic agents or …
Investigating the Alleviating Effect of Fucoidan from Apostichopus japonicus on Ulcerative Colitis by Mice Experiments and In Vitro Simulation of Human Fecal Fermentation
Publication Year: 2025 Source: Foods PMID: 40002018 DOI: 10.3390/foods14040574
BACKGROUND: Fucoidan from Apostichopus japonicus (Aj-FUC) is a marine polysaccharide extracted from the high-quality sea cucumber, which has received increasing attention for its multiple biological activities. METHODS: In this study, Aj-FUC was extracted, and its basic structure was characterized, while the alleviating efficacy of Aj-FUC on ulcerative colitis (UC) was …
Colorectal Neoplasia in Inflammatory Bowel Disease
Publication Year: 2025 Source: Cancers (Basel) PMID: 40002259 DOI: 10.3390/cancers17040665
Patients with inflammatory bowel disease (IBD), including ulcerative colitis and colonic Crohn's disease, are at an increased risk of developing colonic dysplasia and neoplasia. Multiple risk factors have been identified that increase the risk of colonic neoplasia in IBD, including but not limited to underlying disease extent, severity, duration, and …
Antioxidant Activity of Bovine Colostrum in the Colon of a Mouse Model of TNBS-Induced Colitis
Publication Year: 2025 Source: Antioxidants (Basel) PMID: 40002416
(1) Background: Bovine colostrum (BC) is the initial milk produced by cows after giving birth and has revealed significant potential in helping various health conditions, particularly in diseases of the gastrointestinal tract, such as inflammatory bowel disease, including colitis. BC is renowned for its rich composition of components that strengthen …
Novel Insights into the Pathogenesis of Inflammatory Bowel Diseases
Publication Year: 2025 Source: Biomedicines PMID: 40002718 DOI: 10.3390/biomedicines13020305
Inflammatory bowel diseases (IBDs), encompassing Crohn's disease and ulcerative colitis, are complex chronic disorders characterized by an intricate interplay between genetic predisposition, immune dysregulation, gut microbiota alterations, and environmental exposures. This review aims to synthesize recent advances in IBD pathogenesis, exploring key mechanisms and potential avenues for prevention and personalized …
Beyond the "Master" Role in Allergy: Insights into Intestinal Mast Cell Plasticity and Gastrointestinal Diseases
Publication Year: 2025 Source: Biomedicines PMID: 40002733 DOI: 10.3390/biomedicines13020320
Mast cells (MCs) are essential components of the immune system that enter the circulation as immature bone marrow progenitors and differentiate in peripheral organs under the influence of microenvironment factors. As tissue-resident secretory immune cells, MCs rapidly detect the presence of bacteria and parasites because they harbor many surface receptors, …
Early Ustekinumab Use Improves Clinical Outcomes in Biologic-Naive Crohn's Disease Patients: A Retrospective Multicenter Cohort Study in Taiwan
Publication Year: 2025 Source: Biomedicines PMID: 40002805
Background/Objectives: Crohn's disease (CD) is a progressive condition, and early treatment with infliximab combined with an immunosuppressant within six months has been shown to improve clinical outcomes. However, the impact of early ustekinumab (UST) use in biologic-naive CD patients remains unclear. This study aims to address this gap by evaluating …
Immunohistochemistry Analysis in Inflammatory Bowel Disease-Should We Bring to Light Interleukin-10?
Publication Year: 2025 Source: Biomedicines PMID: 40002819 DOI: 10.3390/biomedicines13020406
Background/Objectives: Inflammatory bowel diseases (IBDs) are chronic intestinal disorders with an unpredictable course. In parallel with the advent of new biologic therapies targeting specific interleukin pathways, end-point targets have become more stringent, aiming for mucosal and even histologic healing. Methods: We conducted a prospective study assessing immunohistochemical (IHC) parameters in …
High-Throughput Whole-Exome Sequencing and Large-Scale Computational Analysis to Identify the Genetic Biomarkers to Predict the Vedolizumab Response Status in Inflammatory Bowel Disease Patients from Saudi Arabia
Publication Year: 2025 Source: Biomedicines PMID: 40002872 DOI: 10.3390/biomedicines13020459
Background/Objectives: Vedolizumab (VDZ) is the new monoclonal drug targeting alpha4beta7 integrin for patients with moderate/severe IBD. Between 30 and 45% of patients fail to respond to VDZ after 14-16 weeks of treatment. The aim of the study was to explore the genetic profile of vedolizumab-treated Arab IBD patients in Saudi …
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