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Age as a Predictor of Serum Tumor Necrosis Factor Antagonist Drug and Antidrug Antibody Concentrations in Inflammatory Bowel Disease-A Nationwide Cohort Study
Publication Year: 2025 Source: J Clin Med PMID: 40004589 DOI: 10.3390/jcm14041057
Background/Objectives: Tumor necrosis factor antagonists (anti-TNFs) have been shown to be an effective treatment for inflammatory bowel disease (IBD). Several factors are associated with anti-TNF treatment failure. This study aims to explore the impact of age on serum concentrations of anti-TNF drugs and antidrug antibodies (ADAbs). Methods: We retrospectively reviewed …
Comparative Outcomes of Adalimumab and Infliximab Dose Escalation in Inflammatory Bowel Disease Patients Failing First-Line Biologic Treatment
Publication Year: 2025 Source: J Clin Med PMID: 40004757 DOI: 10.3390/jcm14041228
Background/Objectives: Dose escalation has been commonly used to achieve and maintain response. We aimed to compare the outcomes of adalimumab or infliximab dose escalation in inflammatory bowel disease (IBD) patients. Methods: Treatment persistence (TP) and predictive factors for remission-free treatment discontinuation (r-fTD) were evaluated in patients treated with adalimumab or …
Minimally Invasive Rectal Surgery: Current Status and Future Perspectives in the Era of Digital Surgery
Publication Year: 2025 Source: J Clin Med PMID: 40004765
Over the past two decades, minimally invasive approaches in rectal surgery have changed the landscape of surgical interventions, impacting both malignant and benign pathologies. The dynamic nature of rectal cancer treatment owes much to innovations in surgical techniques, reflected in the expanding literature on available treatment modalities. Local excision, facilitated …
Temporal Trends in the Use of Biological Agents in Patients with Inflammatory Bowel Disease: Real-World Data from a Tertiary Inflammatory Bowel Disease Greek Center During a 5-Year Period
Publication Year: 2025 Source: J Clin Med PMID: 40004889 DOI: 10.3390/jcm14041357
Background/Objectives: Therapeutic management of inflammatory bowel diseases (IBD) is rapidly evolving in the era of novel biological therapies. However, real-world data relating to the usage trends and treatment persistence remain inconsistent. This study aimed to investigate trends in biological use, dose intensification, and treatment persistence in IBD patients, who received …
Artificial Intelligence as a Tool in Diagnosing Inflammatory Bowel Disease in Older Adults
Publication Year: 2025 Source: J Clin Med PMID: 40004890 DOI: 10.3390/jcm14041360
Background/Objectives: The primary objective of our study was to find a potential use for images generated by imagistic investigations by comparing the appearance of a healthy digestive tract to that of a pathological one. Methods: We conducted a cross-sectional observational study involving 60 older adult patients admitted to and followed …
The Importance of Nutriepigenetics in Older Adults with Inflammatory Bowel Disease
Publication Year: 2025 Source: Nutrients PMID: 40004949 DOI: 10.3390/nu17040620
BACKGROUND: Nutriepigenetics, the study of nutritional effects on gene expression, offers new insights into the clinical variability and relapse frequency of inflammatory bowel disease (IBD). As older adult populations are frequently unrepresented in the literature regarding their nutrition's influence on their gene expression, we considered that studying this aspect would …
Evaluating the Efficacy of Probiotics on Disease Progression, Quality of Life, and Nutritional Status Among Patients with Crohn's Disease: A Multicenter, Randomized, Single-Blinded Controlled Trial
Publication Year: 2025 Source: Nutrients PMID: 40005035
BACKGROUND: There is growing interest in the role of gut microbiota in the pathophysiology of inflammatory bowel diseases (IBDs), including Crohn's disease (CD). Probiotics have been proposed as a potential adjunct therapy for these conditions by altering the intestinal environment, although studies on their effectiveness have yielded mixed results. AIM: …
Effects of Selected Food Additives on the Gut Microbiome and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Publication Year: 2025 Source: Medicina (Kaunas) PMID: 40005309
The purpose of this article is to present selected food additives as disruptors of normal intestinal homeostasis with a potential impact on the development of metabolic dysfunction-associated steatotic liver disease (MASLD). A comprehensive literature search was conducted in three major electronic databases: PubMed, ScienceDirect, and Google Scholar. MASLD is a …
Impact of Vitamins, Antibiotics, Probiotics, and History of COVID-19 on the Gut Microbiome in Ulcerative Colitis Patients: A Cross-Sectional Study
Publication Year: 2025 Source: Medicina (Kaunas) PMID: 40005401
Background and Objectives: The human gut microbiome is essential for the health of the host and is affected by antibiotics and coronavirus disease 2019 (COVID-19). The gut microbiome is recognized as a contributing factor in the development of ulcerative colitis. Specific vitamins and probiotics have been demonstrated to positively influence …
Telehealth-An Environmentally Friendly Way to Take Care of Patients with Inflammatory Bowel Disease
Publication Year: 2025 Source: Medicina (Kaunas) PMID: 40005450 DOI: 10.3390/medicina61020332
Background and Objectives: On 11 March 2020, our hospital adapted to the COVID-19 pandemic by becoming a temporary COVID-19 facility, leading to the suspension or delegation of non-COVID-19 services. Among the international IBD community, there were significant concerns regarding the neglect of immunocompromised IBD patients and their increased vulnerability to …
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