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Immune-Mediated Bidirectional Causality Between Inflammatory Bowel Disease and Chronic Periodontitis: Evidence from Mendelian Randomization and Integrative Bioinformatics Analysis
Publication Year: 2025 Source: Biomedicines PMID: 40002889 DOI: 10.3390/biomedicines13020476
Background/Objectives: A bidirectional association between inflammatory bowel disease (IBD) and periodontitis has been observed, yet their causal relationship remains unclear. This study aimed to investigate the potential causal links between these two inflammatory conditions through comprehensive genetic and molecular analyses. Methods: We conducted a bidirectional Mendelian randomization (MR) analysis integrated …
Oral Microbiota and Inflammatory Bowel Diseases: Detection of Emerging Fungal Pathogens and Herpesvirus
Publication Year: 2025 Source: Biomedicines PMID: 40002893 DOI: 10.3390/biomedicines13020480
Background/Objectives: Ulcerative colitis (UC) and Crohn's disease (CD) are the usual clinical forms of inflammatory bowel disease (IBD). Changes in the oral microbiota, especially the presence of emerging fungi and herpesviruses, have been shown to worsen the clinical aspects of IBD. The aim of this study was to screen for …
Laboratory Tests in Inflammatory Bowel Disease: An Evidence-Based Approach to Daily Practice
Publication Year: 2025 Source: Biomedicines PMID: 40002904 DOI: 10.3390/biomedicines13020491
Inflammatory bowel diseases (IBDs) comprise a group of chronic gastrointestinal disorders characterized by periods of relapse and remission. The mainstay of treatment is medical, involving medications such as steroids, immune modulators, monoclonal antibodies (categorized as biologics), and small molecules. These medications can provide profound therapeutic benefits, but they can also …
Hempseed Water-Soluble Protein Fraction and Its Hydrolysate Display Different Biological Features
Publication Year: 2025 Source: Life (Basel) PMID: 40003634 DOI: 10.3390/life15020225
Hempseeds, from the Cannabis sativa plant, and its derivates are a versatile food option for various dietary preferences. Due to their aminoacidic profile, researchers have studied the presence of bioactive peptides in hempseed proteins. In this study, the water-soluble fraction of hempseed protein was extracted, and the derived peptides were …
Lean MASLD and IBD: Exploring the Intersection of Metabolic Dysfunction and the Gut-Liver Axis
Publication Year: 2025 Source: Life (Basel) PMID: 40003697 DOI: 10.3390/life15020288
Metabolic dysfunction-associated steatotic liver disease (MASLD) challenges traditional paradigms by manifesting in lean individuals. The link between MASLD and inflammatory bowel disease (IBD) underscores the importance of the gut-liver axis in disease progression and chronic inflammation. This study evaluates MASLD prevalence, clinical characteristics, and diagnostic predictors in lean individuals with …
Health Benefits of Montmorency Tart Cherry Juice Supplementation in Adults with Mild to Moderate Ulcerative Colitis; A Placebo Randomized Controlled Trial
Publication Year: 2025 Source: Life (Basel) PMID: 40003718 DOI: 10.3390/life15020306
AIMS: Ulcerative colitis (UC) significantly impacts individuals' self-perception, body image, and overall quality of life, while also imposing considerable economic costs. These challenges highlight the necessity for complementary therapeutic strategies with reduced adverse effects to support conventional pharmacological treatments. Among natural interventions, Montmorency tart cherries, noted for their high anthocyanin …
The Simultaneous Deletion of pH-Sensing Receptors GPR4 and OGR1 (GPR68) Ameliorates Colitis with Additive Effects on Multiple Parameters of Inflammation
Publication Year: 2025 Source: Int J Mol Sci PMID: 40004018 DOI: 10.3390/ijms26041552
G protein-coupled receptors (GPRs), including pro-inflammatory GPR4 and ovarian cancer GPR1 (OGR1/GPR68), are involved in the pH sensing of the extracellular space and have been implicated in inflammatory bowel disease (IBD). Previous data show that a loss of GPR4 or OGR1 independently is associated with reduced intestinal inflammation in mouse …
In Vitro Assessment of Bacillus thuringiensis Exopolysaccharides and Their Effects on Gut Microbiota from Ulcerative Colitis In Vitro
Publication Year: 2025 Source: Int J Mol Sci PMID: 40004156
Bacillus thuringiensis exopolysaccharide BPS-2 inhibits malondialdehyde secretion, enhances antioxidant enzyme activities, and significantly improves the antioxidant status of inflammatory cells. In the present study, the apparent morphology and spatial conformation of BPS-2 were analyzed further, and several functional properties were investigated. The results demonstrated that BPS-2 was a polymeric straight-chain …
Pharmacogenetics in Response to Biological Agents in Inflammatory Bowel Disease: A Systematic Review
Publication Year: 2025 Source: Int J Mol Sci PMID: 40004223 DOI: 10.3390/ijms26041760
Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders influenced by microbial, environmental, genetic, and immune factors. The introduction of biological agents has transformed IBD therapy, improving symptoms, reducing complications, and enhancing patients' quality of life. However, approximately 30% of patients exhibit primary non-response, and 50% experience a loss of response …
Bidirectional Interplay Among Non-Coding RNAs, the Microbiome, and the Host During Development and Diseases
Publication Year: 2025 Source: Genes (Basel) PMID: 40004537
It is widely known that the dysregulation of non-coding RNAs (ncRNAs) and dysbiosis of the gut microbiome play significant roles in host development and the progression of various diseases. Emerging evidence has highlighted the bidirectional interplay between ncRNAs and the gut microbiome. This article aims to review the current understanding …
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