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Leukotrienes: Bridging the Inflammatory Gap in Asthma and Inflammatory Bowel Diseases (IBD)
Publication Year: 2025 Source: Compr Physiol PMID: 40568744 DOI: 10.1002/cph4.70022
Leukotrienes are potent inflammatory lipid mediators produced primarily by immune cells. Inflammation, being the center stone of two major disease conditions, namely, asthma and inflammatory bowel disease (IBD), has led researchers to study the role of leukotrienes (LTs) in both these disease settings extensively. Several studies indicate a crucial role …
Discovery of HW201877: A Highly Potent and Orally Bioavailable Inhibitor of 15-Prostaglandin Dehydrogenase to Potentiate Tissue Repair and Regeneration
Publication Year: 2025 Source: J Med Chem PMID: 40568827 DOI: 10.1021/acs.jmedchem.5c01361
Prostaglandin E2 (PGE2), a crucial lipid mediator governing tissue stem cell expansion and regeneration, represents a promising therapeutic target for tissue repair. Based on the premise that inhibiting 15-hydroxyprostaglandin dehydrogenase (15-PGDH), the principal enzyme responsible for PGE2 catabolism, could enhance endogenous PGE2 levels and accelerate tissue regeneration, we rationally designed …
Challenges associated with chronic aortic dissections: single-center experience of iliac branch devices in chronic aortic dissections
Publication Year: 2025 Source: J Cardiovasc Surg (Torino) PMID: 40568831 DOI: 10.23736/S0021-9509.25.13404-6
BACKGROUND: Chronic aortic dissections extending into the iliac arteries present unique anatomical and procedural challenges. Iliac branch devices (IBDs) offer the potential to preserve pelvic perfusion and achieve distal false lumen exclusion, yet their use in dissected anatomies remains off-label and insufficiently studied. This study evaluates the safety, technical success, …
Upadacitinib-Induced Hemolysis in a Patient With Glucose-6-Phosphate Dehydrogenase Deficiency-A Possible Adverse Drug Reaction
Publication Year: 2025 Source: Pharmacol Res Perspect PMID: 40568996
Glucose-6-phosphate-dehydrogenase (G6PD) deficiency is a heterogenous disorder that may lead to severe hemolytic events with the ingestion of fava beans and exposure to certain drugs. We report the first case of a 65-year-old male with Crohn's disease who developed a hemolytic crisis leading to hospitalization shortly after commencement of upadacitinib. …
The pyrethroid insecticide deltamethrin disrupts neuropeptide and monoamine signaling pathways in the gastrointestinal tract
Publication Year: 2025 Source: Toxicol Sci PMID: 40569082
Enteroendocrine cells (EECs) are a rare cell type of the intestinal epithelium. Various subtypes of EECs produce distinct repertoires of monoamines and neuropeptides which modulate intestinal motility and other physiologies. EECs also possess neuron-like properties, suggesting a potential vulnerability to ingested environmental neurotoxicants. One such group of toxicants are pyrethroids, …
Adherence to clinical and endoscopic standards of quality in inflammatory bowel disease: a nationwide survey from the Italian Association of Hospital Gastroenterologists and Endoscopists
Publication Year: 2025 Source: Eur J Gastroenterol Hepatol PMID: 40569217 DOI: 10.1097/MEG.0000000000003025
OBJECTIVE: Quality of care in inflammatory bowel disease (IBD) patients is a major priority as it is associated with better outcomes. We assessed the adherence of Italian gastroenterologists to current international recommendations regarding quality performance measures for clinical and endoscopic IBD activities. METHODS: From March to July 2023, 179 Italian …
Relationship of Intestinal Ultrasound with Clinical, Biochemical, And Endoscopic Disease Severity in Acute Severe Ulcerative Colitis: A Blinded, Prospective Study
Publication Year: 2025 Source: Clin Transl Gastroenterol PMID: 40569318
BACKGROUND: The utility of intestinal ultrasound (IUS) for ASUC is understudied. We correlated IUS to clinical, biochemical, and endoscopic disease severity in ASUC. METHOD: In a blinded, prospective study of 20 ASUC subjects, we analyzed standard IUS parameters (bowel wall thickening, vascular flow, wall stratification) and UC IUS indices (IBUS-SAS, …
Berberine mitigates colitis-associated neuroinflammation and anxiety through modulation of the AMPK/NURR1 pathway
Publication Year: 2025 Source: Naunyn Schmiedebergs Arch Pharmacol PMID: 40569370 DOI: 10.1007/s00210-025-04376-5
Inflammatory bowel disease (IBD) is linked to psychiatric issues like anxiety and depression. Berberine (BER), a natural compound with anti-inflammatory and antioxidant characteristics, shows promise in managing IBD. However, its effects on inflammation-induced anxiety and the underlying mechanisms remain imprecise. This study explores BER's impact on inflammation and anxiety in …
Microbiota interaction with Tregs: a target for colitis
Publication Year: 2025 Source: Clin Transl Oncol PMID: 40569502
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MUSings on a Crohn's Disease Diagnosis
Publication Year: 2025 Source: Dig Dis Sci PMID: 40569515 DOI: 10.1007/s10620-025-09160-2
No Abstract
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