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What the Patient Thinks and What the Patient Does: Placebo, Nocebo, and Therapy Adherence in Ulcerative Colitis
Publication Year: 2025 Source: J Clin Med PMID: 40566096 DOI: 10.3390/jcm14124351
Patients' attitude toward therapy and adherence to treatment are central in determining the long-term outcomes of medical treatment in ulcerative colitis. A complex interplay of differing factors modulates the likelihood of persisting in or discontinuing treatment, including patients' beliefs and concerns about adverse effects of drugs, as well as the …
Serological Assessment of Hepatitis in Patients with Inflammatory Bowel Disease in Taiwan: A Retrospective Cohort Analysis
Publication Year: 2025 Source: Life (Basel) PMID: 40566546 DOI: 10.3390/life15060893
Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD), is a chronic, immune-mediated inflammatory disorder of the gastrointestinal tract. Immunosuppressive therapy administration increases the risk of hepatitis B virus (HBV) and hepatitis C virus (HCV) reactivation. This study aimed to investigate the hepatitis screening rate, serological status, …
Clinical Efficacy of Sodium Butyrate in Managing Pediatric Inflammatory Bowel Disease
Publication Year: 2025 Source: Life (Basel) PMID: 40566555 DOI: 10.3390/life15060902
BACKGROUND: Few studies have evaluated the efficacy of butyric acid in treating children with inflammatory bowel disease (IBD). In children and adolescents with recently diagnosed IBD, the purpose of this research was to assess the efficacy of oral sodium butyrate (the product-patented, sustained and targeted-release form of butyrate MSB((R))) as …
Expert Position Statement: Defining the Role of Intestinal Ultrasound in Assessing Constipation and Faecal Loading
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40566695
BACKGROUND: Intestinal ultrasound has been proposed as a tool to assess non-inflammatory functional gastrointestinal disorders, including constipation and faecal loading. However, well-defined sonographic criteria for these conditions are currently lacking. AIM: To identify and establish specific sonographic parameters that could be used to assess constipation and faecal loading with intestinal …
Decellularized small intestinal hydrogel-encapsulated BMSCs attenuate dextran sulfate sodium-induced colitis in mice via immunomodulation and tissue repair
Publication Year: 2025 Source: J Mater Chem B PMID: 40566954 DOI: 10.1039/d5tb00706b
The treatment of inflammatory bowel disease (IBD) urgently requires effective and safe strategies, and mesenchymal stem cell (MSC)-based therapy has emerged as a research focus due to its immunomodulatory and tissue-repairing capabilities. To enhance the therapeutic efficacy of MSCs, this study developed a decellularized small intestinal (dSI) hydrogel delivery system …
Inflammation-Activatable Nanoscavengers for Sustainable Cell-Free DNA Capture and Cleavage
Publication Year: 2025 Source: Adv Mater PMID: 40567131 DOI: 10.1002/adma.202504557
Cell-free DNA (cfDNA) scavenging using cationic materials represents a promising therapeutic modality for autoimmune diseases (AIDs) such as inflammatory bowel disease (IBD). This approach, however, suffers from critical issues of binding saturation for cfDNA and risk of re-exposure of the captured cfDNA. Herein, an inflammation-activatable nanoscavenger integrating both cfDNA capture …
Development of Ulcerative Colitis in a Patient With Human Immunodeficiency Virus
Publication Year: 2025 Source: Case Rep Gastrointest Med PMID: 40567594 DOI: 10.1155/crgm/2362039
The relationship between the human immunodeficiency virus (HIV) and inflammatory bowel disease (IBD) is poorly understood. The coexistence of the two conditions is uncommon with scattered retrospective studies in the literature. Whereas HIV was initially thought to propagate IBD flares and increase disease severity, more studies are coming out showing …
A Case of Rectal Malakoplakia Associated With Crohn's Disease: An Incidental Finding
Publication Year: 2025 Source: Cureus PMID: 40568297
Malakoplakia is a rare granulomatous disorder characterized by defective phagolysosomal activity in macrophages and the presence of Michaelis-Gutmann (MG) bodies, often affecting immunosuppressed individuals. Although it most frequently involves the genitourinary tract, gastrointestinal involvement - particularly in the rectum and sigmoid colon - has been documented. We report a rare …
Long-Term Outcome of Ciclosporin and Infliximab as Rescue Therapy in Steroid-Refractory Acute Severe Ulcerative Colitis
Publication Year: 2025 Source: Inflamm Intest Dis PMID: 40568347
BACKGROUND: Ciclosporin and infliximab have equal short-term efficacy in treating acute severe ulcerative colitis (ASUC). However, data about long-term outcome and switching to a second rescue therapy are limited. METHODS: Patients with steroid-refractory ASUC treated at a tertiary center in Switzerland were retrospectively analyzed regarding the outcome of different rescue …
Distinct Retrotransposon Transcriptome in Pediatric Crohn's Disease
Publication Year: 2025 Source: medRxiv PMID: 40568672 DOI: 10.1101/2025.04.21.25326010
BACKGROUND AND AIMS: Crohn's disease (CD) is an autoimmune condition with inflammation of the gastrointestinal tract. The etiology of CD is complex with underlying mechanisms only partially elucidated. Retrotransposons, a category of transposable elements within a genome, have been shown to contribute to the pathogenesis of inflammatory and autoimmune disorders. …
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