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Systemic investigation of the mechanism underlying the therapeutic effect of Astragalus membranaceus in ulcerative colitis
Publication Year: 2025 Source: Am J Med Sci PMID: 39009282
No Abstract
A prediction method for the individual serum concentration and therapeutic effect for optimizing adalimumab therapy in inflammatory bowel disease
Publication Year: 2025 Source: J Pharm Pharmacol PMID: 39010700 DOI: 10.1093/jpp/rgae092
OBJECTIVES: Adalimumab (ADM) therapy is effective for inflammatory bowel disease (IBD), but a significant number of IBD patients lose response to ADM. Thus, it is crucial to devise methods to enhance ADM's effectiveness. This study introduces a strategy to predict individual serum concentrations and therapeutic effects to optimize ADM therapy …
Chronic pelvic pain among transgender men and gender diverse adults assigned female at birth
Publication Year: 2025 Source: Andrology PMID: 39011578
No Abstract
Endoscopic Balloon Dilatation of Ileal Pouch-Anal Anastomosis Strictures in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39011760 DOI: 10.1093/ibd/izae128
BACKGROUND: Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the treatment of choice for medically refractory inflammatory bowel disease (IBD). In this systematic review and meta-analysis, we assess outcomes and safety of endoscopic balloon dilatation (EBD) for IPAA strictures. METHODS: A systematic search of numerous databases was performed through June …
Pharmacogenomic Assessment of Genes Implicated in Thiopurine Metabolism and Toxicity in a UK Cohort of Pediatric Patients With Inflammatory Bowel Disease
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39011784
BACKGROUND: Thiopurine drugs are effective treatment options in inflammatory bowel disease and other conditions but discontinued in some patients due to toxicity. METHODS: We investigated thiopurine-induced toxicity in a pediatric inflammatory bowel disease cohort by utilizing exome sequencing data across a panel of 46 genes, including TPMT and NUDT15. RESULTS: …
Concomitant Administration of Ozanimod and Serotonergic Antidepressants in Patients With Ulcerative Colitis or Relapsing Multiple Sclerosis
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39018016
BACKGROUND: Ozanimod, approved for the treatment of moderately to severely active ulcerative colitis (UC) and relapsing multiple sclerosis (RMS), is a weak in vitro monoamine oxidase B (MAO-B) inhibitor. MAO-B inhibitors can cause serotonin accumulation with concomitant use of selective serotonin reuptake inhibitors (SSRIs) or serotonin and norepinephrine reuptake inhibitors …
Morbidity and mortality trends in patients with inflammatory bowel disease presenting with ST elevation myocardial infarction
Publication Year: 2025 Source: Hellenic J Cardiol PMID: 39019329
No Abstract
Intestinal Ultrasound, Fecal Calprotectin, and Their Combination to Predict Endoscopic Mucosal Healing in Ulcerative Colitis: A Real-Life Cross-Sectional Study
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39024105
BACKGROUND: The development of noninvasive markers to assess mucosal healing in ulcerative colitis (UC) is essential in the treat-to-target era. The aim of this study was to evaluate the performance of intestinal ultrasound (IUS), fecal calprotectin (FC), and their combination to assess mucosal healing in UC patients. METHODS: All consecutive …
The IBD Clinic of Tomorrow: Holistic, Patient-Centric, and Value-based Care
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 39025251 DOI: 10.1016/j.cgh.2024.04.042
There is increasing recognition of the associated bi-directional impact of inflammatory bowel disease (IBD) on patient well-being and the potential benefit of multidisciplinary teams to address these unique needs. At certain IBD centers, there has been an evolution towards patient-centric, holistic care to enhance well-being and improve health-related outcomes. Multiple …
The Future of Clinical Trials in Inflammatory Bowel Disease
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 39025252 DOI: 10.1016/j.cgh.2024.06.036
The medical management of inflammatory bowel disease (IBD) has been transformed over the past few decades by the approval of multiple classes of advanced therapies and the integration of more targeted treatment strategies for Crohn's disease and ulcerative colitis. These changes have been driven by an increasing number of pivotal …
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