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Re-evaluating Methods for Assessing Differences in Response in Ileal vs Colonic Crohn's Disease: A Post-hoc Analysis of the FITZROY Trial
Publication Year: 2025 Source: J Crohns Colitis PMID: 39030919
BACKGROUND AND AIMS: The ileum is the most commonly affected segment of the gastrointestinal tract in Crohn's disease [CD]. We aimed to determine whether disease location affects response to filgotinib, a Janus kinase [JAK] inhibitor, in patients with moderately-to-severely active Crohn's disease [CD] and applying appropriate methods to account for …
Autologous Fat Grafting For Perianal Fistula in Behçet's Disease: A Case Report
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39031965
No Abstract
Zinc and Inflammatory Bowel Disease: From Clinical Study to Animal Experiment
Publication Year: 2025 Source: Biol Trace Elem Res PMID: 38805169 DOI: 10.1007/s12011-024-04193-6
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract (GI) with a high incidence rate globally, and IBD patients are often accompanied by zinc deficiency. This review aims to summarize the potential therapeutic value of zinc supplementation in IBD clinical patients and animal models. Zinc supplementation …
Familial Mediterranean fever in patients with inflammatory bowel diseases: a nationwide study from the epi-IIRN
Publication Year: 2025 Source: Rheumatology (Oxford) PMID: 38814796 DOI: 10.1093/rheumatology/keae303
OBJECTIVE: Inflammatory bowel diseases (IBD) and familial Mediterranean fever (FMF) are auto-inflammatory diseases with common clinical and biological features. We aimed to determine their association and characterize the natural history in patients with both diagnoses. METHODS: Utilizing data from the epi-IIRN cohort, which includes 98% of Israel's population, we calculated …
Tofacitinib in Pediatric Ulcerative Colitis: A Retrospective Multicenter Experience
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 38828483
BACKGROUND: Tofacitinib has recently been approved for treatment of moderate-to-severe ulcerative colitis (UC) in adults, yet pediatric data are limited. This international multicenter study describes the effectiveness and safety of tofacitinib in pediatric UC. METHODS: This is a retrospective review of children diagnosed with UC treated with tofacitinib from 16 …
Artificial Intelligence-assisted Video Colonoscopy for Disease Monitoring of Ulcerative Colitis: A Prospective Study
Publication Year: 2025 Source: J Crohns Colitis PMID: 38828734
BACKGROUNDS AND AIMS: The Mayo endoscopic subscore [MES] is the most popular endoscopic disease activity measure of ulcerative colitis [UC]. Artificial intelligence [AI]-assisted colonoscopy is expected to reduce diagnostic variability among endoscopists. However, no study has been conducted to ascertain whether AI-based MES assignments can help predict clinical relapse, nor …
Factors Predicting Loss of Remission in Crohn's Disease Patients in Endoscopic Remission in the Real World: Results From TARGET-IBD
Publication Year: 2025 Source: J Clin Gastroenterol PMID: 38829830 DOI: 10.1097/MCG.0000000000002015
BACKGROUND: There is limited evidence that histologic remission improves outcomes in Crohn's disease (CD). We aimed to characterize a cohort of patients with CD in endoscopic remission and explore factors associated with subsequent loss of remission (LOR). METHODS: In total, 4474 patients were enrolled in TARGET-IBD, a longitudinal, observational cohort …
Mortality of Patients With Inflammatory Bowel Disease in the Faroe Islands From 1966-2020
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 38830628 DOI: 10.1093/ibd/izae120
BACKGROUND: Increased mortality rates have been found in patients suffering from inflammatory bowel disease (IBD). The Faroe Islands have the highest occurrence of IBD, mainly ulcerative colitis (UC). This study investigated mortality of patients with IBD compared with the general Faroese population. METHODS: All patients diagnosed with IBD from 1966-2020 …
Treatment of Chronic Pouchitis With JAK Inhibitors: Results from A Large Multicenter Database
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 38830629
No Abstract
Diagnosis of Inflammatory Bowel Disease-Associated Peripheral Arthritis: A Systematic Review
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 38836521 DOI: 10.1093/ibd/izae114
BACKGROUND: Inflammatory bowel disease (IBD)-associated peripheral spondyloarthritis (pSpA) decreases quality of life and remains poorly understood. Given the prevalence of this condition and its negative impact, it is surprising that evidence-based disease definitions and diagnostic strategies are lacking. This systematic review summarizes available data to facilitate development and validation of …
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