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Efficacy of Ustekinumab and Vedolizumab Among Postoperative Crohn's Disease Patients as Postoperative Prophylaxis and Rescue Therapy: Real-world Data
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 38953641
BACKGROUND: Almost half of patients with Crohn's disease (CD) require bowel surgeries in their lifetime. Due to the high risk of postoperative disease recurrence and high rate of previous antitumor necrosis factor (anti-TNF) failure, often alternative therapy options such as ustekinumab (UST) and vedolizumab (VDZ) are used. We aimed to …
Proactive Therapeutic Drug Monitoring Is Associated With Increased Drug Persistence in Patients With Inflammatory Bowel Disease Treated With Intravenous Vedolizumab
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 38953651 DOI: 10.1093/ibd/izae140
BACKGROUND: There are limited data regarding therapeutic drug monitoring (TDM) of non-anti-tumor necrosis factor therapy in inflammatory bowel disease (IBD). This study aimed to evaluate the efficacy of proactive TDM in IBD patients treated with intravenous (iv) vedolizumab (VDZ). METHODS: This single-center retrospective cohort study included consecutive IBD patients treated …
DAMP-ing IBD: Extinguish the Fire and Prevent Smoldering
Publication Year: 2025 Source: Dig Dis Sci PMID: 38963463 DOI: 10.1007/s10620-024-08523-5
In inflammatory bowel diseases (IBD), the most promising therapies targeting cytokines or immune cell trafficking demonstrate around 40% efficacy. As IBD is a multifactorial inflammation of the intestinal tract, a single-target approach is unlikely to solve this problem, necessitating an alternative strategy that addresses its variability. One approach often overlooked …
After Surgically Induced Remission, Ileal and Colonic Mucosa-Associated Microbiota Predicts Crohn's Disease Recurrence
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 38969076
No Abstract
Quantitative Magnetic Resonance Imaging (qMRI) of the Small Bowel in Crohn's Disease: State-of-the-Art and Future Directions
Publication Year: 2025 Source: J Magn Reson Imaging PMID: 38970359
No Abstract
Following Through: The Impact of Culinary Medicine on Mediterranean Diet Uptake in Inflammatory Bowel Disease
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 38970369 DOI: 10.1093/ibd/izae141
BACKGROUND: The Mediterranean diet (MD) is recommended for all patients with inflammatory bowel disease (IBD) unless there is a specific contraindication. Culinary medicine has emerged as a method for improving dietary education. Patients and caregivers are often invested in making dietary changes to improve disease control. Here, we examine the …
Use of Upadacitinib as Salvage Therapy for Ulcerative Colitis in Pregnancy: A Case Report
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 38970379
No Abstract
Peroxiredoxin 3 Deficiency Exacerbates DSS-Induced Acute Colitis via Exosomal miR-1260b-Mediated Barrier Disruption and Proinflammatory Signaling
Publication Year: 2025 Source: Antioxid Redox Signal PMID: 38970422 DOI: 10.1089/ars.2023.0482
Aims: Peroxiredoxin3 (Prdx3) is an intracellular antioxidant enzyme that is specifically localized in mitochondria and protects against oxidative stress by removing mitochondrial reactive oxygen species (ROS). The intestinal epithelium provides a physical and biochemical barrier that segregates host tissues from commensal bacteria to maintain intestinal homeostasis. An imbalance between the …
Adapting to the Rapidly Changing Landscape of Inflammatory Bowel Disease Management-An Opportunity to Medically Optimize Our Fighting Forces
Publication Year: 2025 Source: Mil Med PMID: 38970441
No Abstract
The Role of DNA Methylation in Gastrointestinal Disease: An Expanded Review of Malignant and Nonmalignant Gastrointestinal Diseases
Publication Year: 2025 Source: Gastroenterology PMID: 38971197
No Abstract
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