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Prebiotics for Induction and Maintenance of Remission in Inflammatory Bowel Disease: Systematic Review and Meta-Analysis
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 38781004 DOI: 10.1093/ibd/izae115
BACKGROUND: Prebiotics are nondigestible carbohydrates fermented by gut bacteria into metabolites that confer health benefits. However, evidence on their role for inflammatory bowel disease (IBD) is unclear. This study systematically evaluated the research on prebiotics for treatment of IBD. METHODS: A search was performed in PubMed, Embase, Cochrane, and Web …
Rigorous Donor Selection for Fecal Microbiota Transplantation in Active Ulcerative Colitis: Key Lessons From a Randomized Controlled Trial Halted for Futility
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 38788915 DOI: 10.1016/j.cgh.2024.05.017
BACKGROUND & AIMS: Rigorous donor preselection on microbiota level, strict anaerobic processing, and repeated fecal microbiota transplantation (FMT) administration were hypothesized to improve FMT induction of remission in ulcerative colitis (UC). METHODS: The RESTORE-UC trial was a multi-centric, double-blind, sham-controlled, randomized trial. Patients with moderate to severe UC (defined by …
Increasing Rates of Bowel Resection Surgery for Stricturing Crohn's Disease in the Biologic Era
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 38795051
BACKGROUND: The era of biologics is associated with declining rates of surgery for Crohn's disease (CD), but the impact on surgery for stricturing CD is unknown. Our study aimed to assess nationwide trends in bowel resection surgery for obstruction in CD since the introduction of infliximab for CD in 1998. …
IBD Is Like a Tree: Reflections From Older Adults With Inflammatory Bowel Disease
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 38934627 DOI: 10.1093/ibd/izae139
BACKGROUND: Despite the growing proportion of older adults with inflammatory bowel disease (IBD), their lived experience is not well understood. IBD literature is generally focused on younger adults, and few studies are qualitative. Older adults may report well-being differently than younger adults, so it is important that we learn about …
Cross-sectional imaging of mimics of inflammatory bowel disease: not everything is Crohn's disease or ulcerative colitis
Publication Year: 2025 Source: Abdom Radiol (NY) PMID: 38935092 DOI: 10.1007/s00261-024-04436-z
Acute and chronic bowel pathologies can often be mistaken for manifestations of inflammatory bowel disease (IBD), and there are many entities with imaging and clinical features that overlap with IBD, making diagnosis difficult. We describe multiple inflammatory, infectious, neoplastic, and vascular entities with imaging and clinical features that may mimic …
Early predictors of intestinal complications in pediatric-onset Crohn's disease: A long-term cohort study in Taiwan
Publication Year: 2025 Source: J Formos Med Assoc PMID: 38937194
No Abstract
HLA-DQA1*05 Allele Carriage and Anti-TNF Therapy Persistence in Inflammatory Bowel Disease
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 38937958 DOI: 10.1093/ibd/izae138
INTRODUCTION: Carriage of the HLA-DQA1*05 allele is associated with development of antidrug antibodies (ADAs) to antitumor necrosis factor (anti-TNF) therapy in patients with Crohn's disease. However, ADA is not uniformly associated with treatment failure. We aimed to determine the impact of carriage of HLA-DQA1*05 allele on outcome of biologic therapy …
Integrating the Patient Perspective to Validate a Measure of Disease Severity in Inflammatory Bowel Disease: Online Survey of Patients and Their Physicians
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 38944765 DOI: 10.1093/ibd/izae127
BACKGROUND: The patient perspective is essential for assessing disease severity, but it is not always adequately considered. We describe how a comprehensive clinical disease severity index (DSI) for inflammatory bowel disease (IBD) correlates with patient global self-assessment (PGSA). METHODS: In an individually linked parallel online survey, physicians provided the DSI, …
Paternal Inflammatory Bowel Disease and the Risk of Pregnancy Loss
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 38944809
BACKGROUND: Only about 30% of conceptions end in live births, yet there are little data on paternal causes of pregnancy loss. Men with inflammatory bowel disease may have multiple disease-related issues that may affect fertility. We aimed to examine pregnancy outcomes in women undergoing assisted reproduction whose male partners had …
Targeting the Interleukin 23 Pathway in Inflammatory Bowel Disease
Publication Year: 2025 Source: Gastroenterology PMID: 38945499 DOI: 10.1053/j.gastro.2024.05.036
Interleukin (IL) 23, a member of the IL12 family of cytokines, maintains intestinal homeostasis, but is also implicated in the pathogenesis of inflammatory bowel diseases (IBDs). IL23 is a heterodimer composed of disulfide-linked p19 and p40 subunits. Humanized monoclonal antibodies selectively targeting the p19 subunit of IL23 are poised to …
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