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A comprehensive review on calcitonin gene-related peptide in the management of gastrointestinal disorders
Publication Year: 2025 Source: Inflammopharmacology PMID: 39934537
The prevalence of gastrointestinal disorders caused by alcohol, Helicobacter pylori, non-steroidal anti-inflammatory drugs, chronic stress and sedentary lifestyle is on the rise. Calcitonin gene-related peptide (CGRP), a 37-amino acid neuropeptide, has emerged as a protective factor against various gastrointestinal issues. Despite its known benefits, the dual role of CGRP in …
Curcumin plus piperine improve body composition in patients with inflammatory bowel disease: a randomized, double-blind, placebo-controlled clinical trial
Publication Year: 2025 Source: Eur J Nutr PMID: 39934549 DOI: 10.1007/s00394-025-03608-x
This study evaluates the effects of oral supplementation of curcumin alone and curcumin plus piperine on body composition, phase angle, and functional capacity in patients with mild to moderate inflammatory bowel disease (IBD). Patients with a diagnosis of IBD, aged 18 years or older with intact kidney and liver function, …
Characterization of risk factors and postoperative pharmacological prophylaxis patterns affecting re-resection in Crohn's disease with surgical recurrence
Publication Year: 2025 Source: Int J Colorectal Dis PMID: 39934552
BACKGROUND: Limited research has focused on the characterization of Crohn's disease (CD) patients with surgical recurrence. This study aimed to evaluate risk factors and postoperative pharmacological prophylaxis patterns for surgical recurrence in CD. METHODS: Data were obtained from 349 CD patients over a 5-year follow-up after initial bowel surgery. Risk …
Metformin suppresses gammadelta T17 cell differentiation alleviating DSS-induced colitis
Publication Year: 2025 Source: Immunol Res PMID: 39934569
Ulcerative colitis (UC) is a chronic, nonspecific, relapsing inflammatory bowel disease. Metformin has pleiotropic effects including anti-inflammatory properties and a notable impact on the gut microbiome. gammadeltaT17 cells play crucial role in initiating and maintaining intestinal inflammation. The effect of metformin on gammadeltaT17 cells remains unclear. This study aims to …
Upadacitinib as rescue therapy for corticosteroid failure acute severe ulcerative colitis: an Asian experience from Taiwan
Publication Year: 2025 Source: Int J Colorectal Dis PMID: 39934573
PURPOSE: Acute severe ulcerative colitis (ASUC) is a medical emergent condition, and approximately one-third of patients with ASUC do not respond to corticosteroid. Whether small molecule drugs are efficient and safe for salvage therapy of ASUC is not well-understood. METHODS: Consecutive patients with ASUC who failed responding to first-line corticosteroid …
Preservation of Blood Flow to the Internal Iliac Artery Using a Custom-Made Single Fenestrated Endograft: A Case Report
Publication Year: 2025 Source: Vasc Endovascular Surg PMID: 39934641 DOI: 10.1177/15385744251315998
PurposeThis report describes the use of a custom-made single-fenestrated endograft to preserve blood flow to the internal iliac artery (IIA) in a patient with an aorto-iliac aneurysm with unsuitable anatomy for a standard iliac branch device (IBD).Case ReportA 56-year-old man presented with an abdominal aortic aneurysm (AAA) of 56 mm …
Odoribacter splanchnicus-derived extracellular vesicles alleviate inflammatory bowel disease by modulating gastrointestinal inflammation and intestinal barrier function via the NLRP3 inflammasome suppression
Publication Year: 2025 Source: Mol Med PMID: 39934686 DOI: 10.1186/s10020-025-01063-2
BACKGROUND: Extracellular vesicles (EVs) derived from specific bacteria exert therapeutic potential on inflammatory diseases. Previous reports suggest the protective role of Odoribacter splanchnicus (O.splanchnicus) in inflammatory bowel disease (IBD). The effect of EVs derived from O.splanchnicus (Os-EVs) and the underlying mechanism on IBD were surveyed here. METHODS: Os-EVs were derived …
Evaluating the association between autoimmune disease and normal tension glaucoma: a retrospective case-control study
Publication Year: 2025 Source: BMC Ophthalmol PMID: 39934714
BACKGROUND: Limited population-based data as well as proposed mechanisms of retinal ganglion cell (RGC) loss suggest autoimmune disease may be a risk factor for glaucoma, the leading cause of irreversible blindness worldwide. Though intraocular pressure (IOP) is the leading risk factor for glaucoma onset and progression, a subset of glaucoma …
Efficacy and safety of mesenchymal stromal cell transplantation in the treatment of autoimmune and rheumatic immune diseases: a systematic review and meta-analysis of randomized controlled trials
Publication Year: 2025 Source: Stem Cell Res Ther PMID: 39934871
OBJECTIVE: This study aims to assess the effectiveness and safety of mesenchymal stem cell (MSC) transplantation in the treatment of autoimmune and rheumatic immune diseases through randomized controlled trials (RCTs). METHODS: Two researchers conducted a comprehensive search of Chinese and English databases from their inception until Dec. 2023. The literature …
The challenges of implementing earlier surgery for terminal ileal Crohn's disease-A qualitative study of the clinician's perspective
Publication Year: 2025 Source: Colorectal Dis PMID: 39934956 DOI: 10.1111/codi.70027
AIM: Evidence suggests that earlier bowel resection may offer more stable remission in localized luminal terminal ileal (TI) Crohn's disease compared with ongoing medical therapy. Surgery is still considered late in the treatment pathway. The aim of this study was to understand the clinician's perspective on 'early' surgery by qualitatively …
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