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Antibiotic Use and Risk of Microscopic Colitis in Older Adults: A Nationwide Self-Controlled Case Series Study
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 39935241 DOI: 10.1111/apt.70028
BACKGROUND: Several drugs have been linked to the risk of microscopic colitis (MC), a condition characterised by watery, non-bloody diarrhoea. Antibiotics can induce similar symptoms, but their connection to MC remains unclear. AIM: To investigate the antibiotic-related risks of MC in adults aged 65 years and older. METHODS: This was …
The prevalence of constipation in children with new diagnosis of inflammatory bowel disease: A retrospective study
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 39935294 DOI: 10.1002/jpn3.70005
OBJECTIVES: Functional constipation (FC) is a common problem in childhood and the first-line therapy is macrogol. The role of FC in the onset of inflammatory bowel disease (IBD) is poorly understood. Our main aim was to investigate the prevalence of FC in children before the diagnosis of IBD. METHODS: This …
Retrospective Cohort Analysis of 1-Hour Infliximab Infusions in Pediatric Patients
Publication Year: 2025 Source: J Pediatr Pharmacol Ther PMID: 39935559
OBJECTIVE: This study aimed to characterize and assess the safety of a 1-hour infliximab infusion in a cohort of pediatric patients. METHODS: A retrospective chart review of pediatric patients that received a 1-hour infliximab or its biosimilar infusion for a gastrointestinal or rheumatologic condition was conducted. Infusions were included if …
Mendelian randomization analysis reveals genetic evidence for a causal link between inflammatory bowel disease and uterine cervical neoplasms
Publication Year: 2025 Source: Front Genet PMID: 39935692 DOI: 10.3389/fgene.2024.1436512
BACKGROUND: Inflammatory bowel disease (IBD) has been reported to be associated with risk of uterine cervical neoplasm. We aimed to evaluate the causal relationship between IBD and uterine cervical neoplasm using a bidirectional Mendelian randomization analysis. METHODS: We derived instrumental variables for IBD, including Crohn's disease and ulcerative colitis, from …
Understanding the Lived Experience After Colectomy and Ileal Pouch-Anal Anastomosis for Ulcerative Colitis: A Qualitative Study
Publication Year: 2025 Source: Crohns Colitis 360 PMID: 39936138
BACKGROUND: The patient experience after ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC) remains poorly defined, resulting in heterogeneity in clinical assessments and research. We performed a qualitative study to better understand the experience of patients after IPAA for UC, with a focus on the symptoms experienced by patients and …
Living Beyond IBD: A Patient's Experience With EIMs and the Case for Multidisciplinary Care
Publication Year: 2025 Source: Crohns Colitis 360 PMID: 39936139 DOI: 10.1093/crocol/otaf006
This editorial explores the complex relationship between inflammatory bowel disease (IBD) and extra-intestinal manifestations (EIMs) and underscores the clinician's critical need for comprehensive EIM care, as well as the physical and emotional burden imposed on the patient. The editorial concludes with actionable steps for clinicians and a call to advance …
Saussurea costus alleviates ulcerative colitis by regulating the gut microbiota and improving intestinal barrier integrity
Publication Year: 2025 Source: Front Cell Infect Microbiol PMID: 39936162
INTRODUCTION: The global health challenge of ulcerative colitis (UC) has been classified by the WHO as a modern refractory disease, commonly referred to as green cancer, with limited treatment options still available, highlighting the urgent need for the development of new therapeutic strategies. Recent pharmacological research has shown that traditional …
Lysosomal Fe(2+) influx through MCOLN1 channel prevents sustained inflammation by limiting PHDs-regulated NFKB activation in macrophages
Publication Year: 2025 Source: Autophagy PMID: 39936589 DOI: 10.1080/15548627.2025.2465396
Lysosomes are best known for their involvement in inflammatory responses, where they participate in the macroautophagy/autophagy process to eliminate inflammasomes. Recently, we have identified a previously overlooked function of lysosomes in regulating macrophage inflammatory responses. Specifically, lysosomes finely control the production of IL1B (interleukin 1 beta) by manipulating the release …
Gut commensal Alistipes shahii improves experimental colitis in mice with reduced intestinal epithelial damage and cytokine secretion
Publication Year: 2025 Source: mSystems PMID: 39936902 DOI: 10.1128/msystems.01607-24
The commensal bacterium Alistipes shahii is a core microbe of the human gut microbiome and its abundance is negatively correlated with inflammatory bowel diseases (IBDs). However, its fundamental role in regulating inflammatory response remains unknown. Using a dextran sulfate sodium (DSS)-induced colitis mouse model, we examined the effect of A. …
Molecular Mechanisms and Clinical Aspects of Colitis-Associated Cancer in Ulcerative Colitis
Publication Year: 2025 Source: Cells PMID: 39936954
Inflammatory bowel diseases have long been recognized as entities with a higher risk of colorectal cancer. An increasing amount of information has been published regarding ulcerative colitis-associated colorectal cancer and its unique mechanisms in recent decades, as ulcerative colitis constitutes a chronic process characterized by cycles of activity and remission …
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