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Body weight-range based initial dosing of ustekinumab in Crohn's disease: Is it an ideal approach?
Publication Year: 2025 Source: Dig Liver Dis PMID: 39939201
BACKGROUND & AIMS: The initial intravenous dose of ustekinumab (UST) for treating Crohn's disease (CD) is recommended based on body weight ranges for clinical convenience. However, patients whose body weight nears the upper threshold may receive a relatively lower dose (<6 mg/kg) based on current dosage calculations. We aimed to …
Characteristics and surgical outcomes of small intestine-rectal fistulas in patients with Crohn's disease
Publication Year: 2025 Source: Int J Colorectal Dis PMID: 39939354
PURPOSE: Small intestine-rectal fistulas are a rare and complex complication in Crohn's disease, posing significant diagnostic and management challenges. This study aims to investigate their distinctive features and evaluates surgical outcomes. METHODS: We conducted a retrospective analysis of Crohn's disease patients with small intestine-rectal fistulas who underwent surgery from January …
Changes of leucine-rich alpha 2 glycoprotein could be a marker of changes of endoscopic and histologic activity of ulcerative colitis
Publication Year: 2025 Source: Sci Rep PMID: 39939376
Leucine-rich alpha 2 glycoprotein (LRG) is one of the serum biomarkers for disease activity of ulcerative colitis (UC). We focused on the correlation between the changes of LRG and the changes of endoscopic and histologic activity of UC, in comparison to the changes of fecal calprotectin (Fcal), fecal immunochemical test …
Lactobacillus fermentum 016 Alleviates Mice Colitis by Modulating Oxidative Stress, Gut Microbiota, and Microbial Metabolism
Publication Year: 2025 Source: Nutrients PMID: 39940311 DOI: 10.3390/nu17030452
Ulcerative colitis (UC) is a chronic and progressive inflammatory gastrointestinal disease closely associated with gut microbiota dysbiosis and metabolic homeostasis disruption. Although targeted microbial therapies are an emerging intervention strategy for inflammatory bowel disease (IBD), the mechanisms by which specific probiotics, such as Lactobacillus fermentum 016 (LF), alleviate UC remain …
Is There Any Association Between Fat Body Mass and Bone Mineral Density in Patients with Crohn's Disease and Ulcerative Colitis?
Publication Year: 2025 Source: Nutrients PMID: 39940324 DOI: 10.3390/nu17030466
Background: The study aimed to investigate the association between fat body mass and bone mineral density (BMD) of the lumbar spine (L1-L4), femoral neck, and total body. Methods: We studied 95 patients with Crohn's disease (CD), 68 with ulcerative colitis (UC), and 40 healthy adults (control group-CG) aged 18-50 years …
From Evidence to Practice: A Narrative Framework for Integrating the Mediterranean Diet into Inflammatory Bowel Disease Management
Publication Year: 2025 Source: Nutrients PMID: 39940329 DOI: 10.3390/nu17030470
Emerging evidence underscores the pivotal role of diet in preventing and managing inflammatory bowel disease (IBD). As our comprehension of the microbiome's role in IBD expands, dietary modifications are increasingly recognized as potential adjuncts or primary therapeutic strategies. Key components of the Mediterranean diet (MD)-including microbiota-accessible carbohydrates, omega-3 fatty acids, …
Specific Composition Diets and Improvement of Symptoms of Immune-Mediated Inflammatory Diseases in Adulthood-Could the Comparison Between Diets Be Improved?
Publication Year: 2025 Source: Nutrients PMID: 39940351 DOI: 10.3390/nu17030493
Diet is considered a possible cofactor, which affects the immune system and potentially causes dysregulation of intestinal homeostasis and inflammation. This study aimed to review the quality of evidence on the effects of specific diet composition on symptoms of immune-mediated inflammatory diseases (IMIDs), including rheumatoid arthritis (RA), spondyloarthritis, multiple sclerosis …
Nutritional Habits in Crohn's Disease Onset and Management
Publication Year: 2025 Source: Nutrients PMID: 39940417
Crohn's disease (CD)'s activation factors are still unclear. However, they are reported to involve an interaction between genetic susceptibility and unhealthy lifestyle factors like smoking, alcohol consumption, low physical activity, low BMI (<18.5 kg/m(2)), and probably unbalanced nutritional habits. Therefore, the aim of the present review is to demonstrate the …
Polysaccharides: The Sweet and Bitter Impacts on Cardiovascular Risk
Publication Year: 2025 Source: Polymers (Basel) PMID: 39940607
Cardiovascular risk is a clinical factor that represents the probability of developing cardiovascular diseases (CVDs). This risk is shaped by non-modifiable and modifiable factors, including dietary patterns, which are the main lifestyle factor influencing CVD. Dietary polysaccharides, integral to nutrition, have varying effects on cardiovascular health depending on their type …
Anti-Inflammatory Effects of Algae-Derived Biomolecules in Gut Health: A Review
Publication Year: 2025 Source: Int J Mol Sci PMID: 39940655 DOI: 10.3390/ijms26030885
Under physiological conditions, the inflammatory response acts as a biological defense against tissue damage or infection, and is rapidly resolved once the infection is cleared. However, chronic inflammatory diseases, including inflammatory bowel disease (IBD), have become increasingly widespread in the last decades, placing a burden on the quality of life …
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