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Patients with Irritable Bowel Syndrome Exhibit Aberrant Expression of Endogenous Retroviruses and SETDB1
Publication Year: 2025 Source: Cells PMID: 39936987
Irritable bowel syndrome (IBS) is a common disease, whose etiopathogenesis is poorly understood. Human endogenous retroviruses (HERVs) originate from ancient infections of germinal cells and represent 8% of our DNA. Most HERVs have become defective due to the accumulated mutations; some can, however, still be activated, and their altered expressions …
MK2 Inhibition in CD4+ T Cells Protects Against IFNγ and IL-17A, Chronic Inflammation, and Fibrosis in Inflammatory Bowel Disease Models
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39937137 DOI: 10.1093/ibd/izaf026
BACKGROUND: CD4+ T cells contribute to chronic inflammation and fibrosis in inflammatory bowel disease (IBD), but the cellular mechanisms remain elusive. We have found that the mitogen-activated protein kinase 2 (MK2) pathway plays a major role in inflammation and overall pathology in IBD. Thus, here, we examined the role of …
Adverse maternal outcomes after vaginal versus caesarean delivery in women with Crohn's disease and prior perianal surgery: a population-based study
Publication Year: 2025 Source: J Crohns Colitis PMID: 39937749
BACKGROUND AND AIMS: For pregnant women with perianal Crohn's disease (CD), major guidelines recommend delivery by caesarean section (c-section) for active disease, and that delivery mode be governed by obstetric indications for women with inactive disease. However, a significant gray zone exists between active versus inactive disease, such as for …
The clinical significance and biological function of tropomyosin 3 in ulcerative colitis
Publication Year: 2025 Source: Tissue Cell PMID: 39938429
BACKGROUND: Ulcerative colitis (UC) is a lifelong chronic inflammatory disease that is characterized by the absence of specific markers for diagnosis and prognosis. TPM3 is an integral component of the thin filament, responsible for the structural stability of actin filaments and modulation of cytoskeletal function. This study investigated the regulatory …
Colorectal Cancer: Epidemiology, Risk Factors, and Public Health Strategies
Publication Year: 2025 Source: Digestion PMID: 39938491
BACKGROUND: Colorectal cancer (CRC) is a significant global health issue, ranking as the third most commonly diagnosed cancer and the second leading cause of cancer-related deaths. Countries with a high Human Development Index (HDI) report the highest incidence rates, driven by dietary and lifestyle factors. In contrast, low-to-middle HDI countries …
Decoding the Gut-Brain Axis: A Journey toward Targeted Interventions for Disorders-of-Gut-Brain Interaction
Publication Year: 2025 Source: Dig Dis PMID: 39938496
BACKGROUND: The gut-brain axis is a bidirectional communication pathway connecting the gastrointestinal tract and the brain. Disorders of gut-brain interaction (DGBI) manifest as highly prevalent gastrointestinal disorders such as irritable bowel syndrome (IBS) or functional dyspepsia (FD). SUMMARY: The initial focus of DGBI research was on the effects of psychological …
Surveillance and Endoscopic Resection of Ulcerative Colitis-Associated Neoplasia: A Japanese Perspective
Publication Year: 2025 Source: Digestion PMID: 39938497
BACKGROUND: Patients with a long history of ulcerative colitis (UC) are at risk of developing a serious complication known as UC-associated neoplasia (UCAN). Because the treatment strategy for UCAN greatly differs from that for sporadic tumors, UCAN needs to be distinguished from sporadic tumors. This article provides an overview of …
Increased intracellular stress responses and decreased KLF2 in adult patients with atopic dermatitis
Publication Year: 2025 Source: Cell Stress Chaperones PMID: 39938773
Atopic dermatitis (AD) is prone to exacerbations in response to various triggering factors and flare-ups after remission. We searched for molecules associated with relapse/exacerbation of AD among molecules with altered gene expression in the skin of patients with AD. Microarray analyses were performed on lesional and nonlesional skin of adolescent …
Forecasting Inflammatory Bowel Disease Activity With Wearable Devices
Publication Year: 2025 Source: Gastroenterology PMID: 39938809
No Abstract
Outcomes of oral vancomycin therapy in children with atypical ulcerative colitis with or without confirmed primary sclerosing cholangitis: a real-world observational study
Publication Year: 2025 Source: BMJ Open Gastroenterol PMID: 39938966 DOI: 10.1136/bmjgast-2024-001605
OBJECTIVES: Atypical ulcerative colitis (UC) presenting reverse gradient colitis, backwash ileitis, or rectal sparing and/or positive atypical antineutrophil cytoplasmic antibody serology is often associated with primary sclerosing cholangitis (PSC) and can be resistant to conventional medical therapies (CMT) for inflammatory bowel diseases. We report short-term and long-term outcomes of oral …
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