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Yeast-Inspired Orally-Administered Nanocomposite Scavenges Oxidative Stress and Restores Gut Immune Homeostasis for Inflammatory Bowel Disease Treatment
Publication Year: 2025 Source: ACS Nano PMID: 39943645 DOI: 10.1021/acsnano.4c18099
Excessive oxidative stress, dysregulated immune homeostasis, and disruption of the intestinal epithelial barrier are crucial features of inflammatory bowel disease (IBD). Traditional treatments focusing solely on inflammation resolution remain unsatisfactory. Herein, a yeast-inspired orally administered nanocomposite was developed. First, the MD@MPDA core was fabricated by integrating manganese dioxide (MnO(2)) nanozymes …
Nanoencapsulation enhanced the performance of β-carotene for ameliorating inflammation in patient-derived organoids
Publication Year: 2025 Source: Nanomedicine (Lond) PMID: 39943855
AIM: This study aims to develop a nanocarrier system for the oral delivery of beta-Carotene (BC) (as a model therapeutic agent) and to test its efficacy in ameliorating inflammation in an ulcerative colitis (UC) patient-derived organoid. MATERIALS & METHODS: BC was encapsulated in a zein protein nano-cage surface-functionalized with pectin …
Paradoxical psoriasiform eruption in pediatric patients with inflammatory bowel disease treated with adalimumab
Publication Year: 2025 Source: Ital J Dermatol Venerol PMID: 39943901
No Abstract
Exacerbation of polyethylene microplastics in animal models of DSS-induced colitis through damage to intestinal epithelial cell conjunctions
Publication Year: 2025 Source: Curr Res Toxicol PMID: 39944107 DOI: 10.1016/j.crtox.2025.100217
Microplastics are pollutants that occur in various environments and habitats. Inflammatory bowel disease (IBD) is a chronic inflammatory disease accompanied with diarrhea, and the number of patients has increased worldwide. In this study, manufactured fragmented polyethylene-microplastics in the size range of 10-30 ㎛, were oxidized by exposure to ultraviolet light, …
Causal relationship between inflammatory bowel disease and sex: a Mendelian randomization study
Publication Year: 2025 Source: Front Endocrinol (Lausanne) PMID: 39944207 DOI: 10.3389/fendo.2025.1338701
OBJECTIVE: The aim of this study was to investigate the bidirectional causal relationship between sex hormones and IBD through a two-sample bidirectional Mendelian randomization (MR) study. METHODS: Based on Genome-Wide Association Study (GWAS) pooled data on SHBG, total testosterone, bioavailable testosterone, estradiol, and IBD in a European population, we performed …
Interprofessional approach to personalized medication management and therapy optimization in IBD care
Publication Year: 2025 Source: Front Med (Lausanne) PMID: 39944491 DOI: 10.3389/fmed.2025.1446695
A considerable number of patients with chronic inflammatory bowel diseases (IBD) are required to manage extensive polypharmaceutical regimes, which significantly elevates the risk of drug-drug interactions. Also, the disease's impact often leads to the consumption of additional self-medication by the patients such as naturopathic remedies to alleviate disease-induced suffering and …
Editorial: Advances in the pharmacotherapy of chronic pelvic pain conditions
Publication Year: 2025 Source: Front Pharmacol PMID: 39944623
No Abstract
Individual-network based predictions of microbial interaction signatures for response to biological therapies in IBD patients
Publication Year: 2025 Source: Front Mol Biosci PMID: 39944755 DOI: 10.3389/fmolb.2024.1490533
Inflammatory Bowel Disease (IBD), which includes Ulcerative Colitis (UC) and Crohn's Disease (CD), is marked by dysbiosis of the gut microbiome. Despite therapeutic interventions with biological agents like Vedolizumab, Ustekinumab, and anti-TNF agents, the variability in clinical, histological, and molecular responses remains significant due to inter-individual and inter-population differences. This …
A transcriptomic score to classify the inflammation-dysplasia-cancer sequence lesions in inflammatory bowel disease
Publication Year: 2025 Source: J Crohns Colitis PMID: 39945142 DOI: 10.1093/ecco-jcc/jjaf026
BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) is associated with a higher risk of developing colorectal cancer, according to the inflammation-dysplasia-cancer (IDC) sequence from inflammation to colitis-associated colorectal cancer (CAC). The objective of this study was to identify and generate a transcriptomic signature and score, related to the IDC sequence, …
Prevalence, incidence, and mortality of inflammatory bowel disease in the Netherlands: development and external validation of machine learning models
Publication Year: 2025 Source: J Crohns Colitis PMID: 39945210 DOI: 10.1093/ecco-jcc/jjaf017
BACKGROUND AND AIMS: Large registries are promising tools to study the epidemiology of inflammatory bowel disease (IBD). We aimed to develop and validate machine learning models to identify IBD cases in administrative data, aiming to determine the prevalence, incidence, and mortality of IBD in the Netherlands. METHODS: We developed machine …
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