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Visualizing enterohepatic circulation in vivo by sensitive (19)F MRI with a fluorinated ferrous chelate-based small molecule probe
Publication Year: 2025 Source: Biomaterials PMID: 39848003 DOI: 10.1016/j.biomaterials.2024.123073
Enterohepatic circulation (EHC) is a critical biological process for the normal regulation of many endogenous biomolecules and the increased retention of various exogenous substances. The status of EHC is closely related to the ordinary functioning of several digestive organs. However, it remains a challenge to achieve in vivo real-time visualization …
An Overview of Early-Life Gut Microbiota Modulation Strategies
Publication Year: 2025 Source: Ann Nutr Metab PMID: 39848238
BACKGROUND: The gut microbiota, or microbiome, is essential for human health. Early-life factors such as delivery mode, diet, and antibiotic use shape its composition, impacting both short- and long-term health outcomes. Dysbiosis, or alterations in the gut microbiota, is linked to conditions such as allergies, asthma, obesity, diabetes, inflammatory bowel …
Outcomes of endoscopic submucosal dissection for high-risk colorectal colitis-associated neoplasia in inflammatory bowel disease
Publication Year: 2025 Source: Endoscopy PMID: 39848273 DOI: 10.1055/a-2524-3553
BACKGROUND: Patients with inflammatory bowel disease (IBD) have an increased risk of colorectal cancer. High-risk colorectal colitis-associated neoplasia (HR-CAN) can be difficult to treat using traditional endoscopic resection methods. This study evaluated the outcomes of endoscopic submucosal dissection (ESD) in patients with IBD and HR-CANs. METHODS: This retrospective multicenter study …
Prevalence and outcome of sarcopenia in patients with inflammatory bowel disease: a follow-up study
Publication Year: 2025 Source: Intest Res PMID: 39848333 DOI: 10.5217/ir.2024.00096
BACKGROUND/AIMS: Sarcopenia is implicated in inflammatory bowel disease (IBD) complications and surgical outcomes. This study aimed to investigate the prevalence and follow-up of sarcopenia in patients with IBD. METHODS: Consecutive consenting patients with IBD aged > 18 years were included. Patients with associated sarcopenic diseases were excluded. All had measurements …
Effectiveness and safety of biosimilars in pediatric inflammatory bowel diseases: an observational longitudinal study on the French National Health Data System
Publication Year: 2025 Source: World J Pediatr PMID: 39849273 DOI: 10.1007/s12519-024-00873-4
BACKGROUND: Data on biosimilar use in pediatric inflammatory bowel diseases (IBD) are scarce compared to the status of studies in adults, resulting in limitations in its treatment. We compared effectiveness and safety of biosimilars versus originators in this population. METHODS: We used data from the French National Health Data System …
Dietary content and eating behavior in ulcerative colitis: a narrative review and future perspective
Publication Year: 2025 Source: Nutr J PMID: 39849464
Ulcerative colitis (UC) has experienced a steady increase in global incidence and prevalence recently. Current research into UC pathogenesis focuses on the complex interplay of genetic and environmental factors with the immune system and gut microbiome, leading to disruption of the intestinal barrier. Normally, the microbiome, intestinal epithelium, and immune …
Wound irrigation and peritoneal lavage with antiseptic/antibiotic solution before wound closure during gastrointestinal surgery: a systematic review and meta-analysis
Publication Year: 2025 Source: BMC Surg PMID: 39849481
BACKGROUND: Surgical site infections (SSIs) can affect mortality, morbidity, and medical costs. Although it has recently been reported that washing with antiseptic/antibiotic solution can prevent SSI in clean surgery, the clinical impact in gastrointestinal surgery is still uncertain. Therefore, we performed a systematic review and meta-analysis to evaluate the efficacy …
Clinical benefits and risks of remote patient monitoring: an overview and assessment of methodological rigour of systematic reviews for selected patient groups
Publication Year: 2025 Source: BMC Health Serv Res PMID: 39849519
BACKGROUND: Remote patient monitoring implies continuous follow-up of health-related parameters of patients outside healthcare facilities. Patients share health-related data with their healthcare unit and obtain feedback (which may be automatically generated if data are within a predefined range). The goals of remote patient monitoring are improvements for patients and reduced …
Neutrophil-macrophage hybrid membrane-coated prussian blue nanozyme for ulcerative colitis treatment and mechanistic insights
Publication Year: 2025 Source: J Nanobiotechnology PMID: 39849556
BACKGROUND: Ulcerative colitis (UC) is a chronic and recurrent digestive tract disease that can lead to significant morbidity and mortality. The pathogenesis of UC is intricately associated with the presence of reactive oxygen species (ROS). Prussian blue (PB), an inorganic nanozyme with potent antioxidant properties, has been extensively applied in …
Frequency and Risk Factors of Advanced Neoplasia in Korean Inflammatory Bowel Disease Patients with Low-grade Dysplasia
Publication Year: 2025 Source: Korean J Gastroenterol PMID: 39849810 DOI: 10.4166/kjg.2024.105
BACKGROUND/AIMS: Studies on the clinical outcomes after detecting low-grade dysplasia (LGD) in patients with inflammatory bowel disease (IBD) are insufficient. This study evaluated the clinical features, frequency, and risk factors for advanced neoplasia in patients with IBD after an LGD diagnosis. METHODS: The medical records of 166 patients with IBD …
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