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Programmable Food-Derived Peptide Coassembly Strategies for Boosting Targeted Colitis Therapy by Enhancing Oral Bioavailability and Restoring Gut Microenvironment Homeostasis
Publication Year: 2025 Source: ACS Nano PMID: 39745599
Orally targeting nanostrategies of multiple nutraceuticals have attracted increasing attention in ulcerative colitis (UC) therapy for superior patient compliance, cost-effectiveness, and biocompatibility. However, the actual targeting delivery and bioefficacy of nutraceuticals are extremely restricted by their poor solubility, interior gastrointestinal retention, and base permeability. Herein, we developed controllable colon-targeting nanoparticles …
Mouse CD8+ T cell subsets differentially generate IL-17-expressing cells in the colon epithelium and lamina propria
Publication Year: 2025 Source: Clin Exp Immunol PMID: 39745881
Colon-resident CD8+ T cells actively contribute to gut homeostasis and the pathogenesis of inflammatory bowel disease. However, their heterogeneity in generating IL-17-expressing CD8+ T cells, i.e. Tc17 cells, has not been thoroughly revealed. This study aims to characterize the abilities of mouse colonic intraepithelial (IE) and lamina propria (LP) CD8+ …
Jacalin Attenuates Colitis-Associated Colorectal Carcinogenesis by Inhibiting Tumor Cell Proliferation and Intestinal Inflammation
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39745886
BACKGROUND: Colorectal cancer (CRC) remains a significant cause of morbidity and mortality worldwide. In patients with inflammatory bowel disease, who have twice the risk of developing CRC, chronic inflammation has been recognized to contribute to colitis-associated cancer (CAC) development. Jacalin, a lectin extracted from jackfruit seeds, has been shown to …
Anti-TNF nonresponse in ulcerative colitis: correcting for mucosal drug exposure reveals distinct cytokine profiles
Publication Year: 2025 Source: J Crohns Colitis PMID: 39745888
INTRODUCTION: It remains unclear why up to 30% of ulcerative colitis (UC) patients do not respond to tumor necrosis factor inhibitors (TNFi). Validated biomarkers for nonresponse (N)R) are lacking. Most studies investigating underlying mechanisms do not differentiate between pharmacokinetic and inflammatory mechanisms. We therefore aimed to develop a framework to …
Correction: Self-reported food intolerance, dietary supplement use and malnutrition in chronic inflammatory bowel diseases: Findings from a cross-sectional study in Lebanon
Publication Year: 2025 Source: PLoS One PMID: 39745994
[This corrects the article DOI: 10.1371/journal.pone.0305352.].
Wogonin effects on the efflux transporters BCRP and MRP2, explain its effectiveness in ulcerative colitis: Implications for metabolic and transport interactions
Publication Year: 2025 Source: Pharmacol Res PMID: 39746499
No Abstract
Altered functional network topology properties to detect anxiety and depression caused by Crohn's disease and disease severity
Publication Year: 2025 Source: Brain Res Bull PMID: 39746522
No Abstract
Targeting the EP2 receptor ameliorates inflammatory bowel disease in mice by enhancing the immunosuppressive activity of T(reg) cells
Publication Year: 2025 Source: Mucosal Immunol PMID: 39746548 DOI: 10.1016/j.mucimm.2024.12.014
Inflammatory bowel diseases (IBDs) are characterized by unrestrained innate and adaptive immune responses and compromised intestinal epithelial barrier integrity. Regulatory T (T(reg)) cells are crucial for maintaining self-tolerance and immune homeostasis in intestinal tissues. Prostaglandin E(2) (PGE(2)), a bioactive lipid compound derived from arachidonic acid, can modulate T cell functions …
Dihydromyricetin/montmorillonite intercalation compounds ameliorates DSS-induced colitis: Role of intestinal epithelial barrier, NLRP3 inflammasome pathway and gut microbiota
Publication Year: 2025 Source: Int J Pharm PMID: 39746581
No Abstract
Prior Anti-TNF Exposure Is Associated with an Increased Risk of Short- and Long-Term Colectomy in Acute Severe Ulcerative Colitis
Publication Year: 2025 Source: Dig Dis Sci PMID: 39746889
BACKGROUND: Acute severe ulcerative colitis (ASUC) affects up to 25% of patients with UC and is associated with an increased risk of colectomy. Despite improvements in medical management, individual patient prognostication and risk stratification in ASUC remains challenging. We explored clinical, biochemical, and endoscopic factors as potential predictors for colectomy …
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