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Acute severe ulcerative colitis: defining the precise moment for colectomy
Publication Year: 2025 Source: Expert Rev Gastroenterol Hepatol PMID: 39753508
INTRODUCTION: Acute severe ulcerative colitis (ASUC) is a critical manifestation of ulcerative colitis (UC), often necessitating colectomy when medical management fails. Despite advancements in therapeutic interventions such as corticosteroids, biologics, and JAK inhibitors, a significant proportion of patients require surgery, with colectomy rates ranging from 10% to 15%. AREAS COVERED: …
Author Correction: TNF inhibitors target a mevalonate metabolite/TRPM2/calcium signaling axis in neutrophils to dampen vasculitis in Behçet's disease
Publication Year: 2025 Source: Nat Commun PMID: 39753557
No Abstract
A reduction in effective population size has not relaxed purifying selection in the human population of Eivissa (Balearic Islands)
Publication Year: 2025 Source: Sci Rep PMID: 39753655 DOI: 10.1038/s41598-024-84271-w
Ibiza (Eivissa) is one of the main Balearic Islands in the western Mediterranean. Recent studies have highlighted the genetic distinctiveness of present-day Eivissans within the region and suggested it could be attributed to the genetic drift caused by recent demographic events. Whether this distinctiveness emerged from a differential demographic history, …
NUFIP1 integrates amino acid sensing and DNA damage response to maintain the intestinal homeostasis
Publication Year: 2025 Source: Nat Metab PMID: 39753713 DOI: 10.1038/s42255-024-01179-5
Nutrient availability strongly affects intestinal homeostasis. Here, we report that low-protein (LP) diets decrease amino acids levels, impair the DNA damage response (DDR), cause DNA damage and exacerbate inflammation in intestinal tissues of male mice with inflammatory bowel disease (IBD). Intriguingly, loss of nuclear fragile X mental retardation-interacting protein 1 …
Probiotics Exert Gut Immunomodulatory Effects by Regulating the Expression of Host miRNAs
Publication Year: 2025 Source: Probiotics Antimicrob Proteins PMID: 39754704 DOI: 10.1007/s12602-024-10443-9
Probiotics exert a diverse range of immunomodulatory effects on the human gut immune system. These mechanisms encompass strengthening the intestinal mucosal barrier, inhibiting pathogen adhesion and colonization, stimulating immune modulation, and fostering the production of beneficial substances. As a result, probiotics hold significant potential in the prevention and treatment of …
Berberine‑calcium alginate-coated macrophage membrane-derived nanovesicles for the oral treatment of ulcerative colitis
Publication Year: 2025 Source: Int J Biol Macromol PMID: 39755317
In this study, we developed calcium alginate-coated nanovesicles derived from macrophage membranes loaded with berberine (Ber@MVs-CA) for the oral treatment of ulcerative colitis (UC). Ber@MVs-CA demonstrates resistance to gastric acid and controlled drug release in the colonic pH environment, while actively targeting sites of ulcerative colitis injury. pH-responsive release of …
Dasatinib-induced colitis in a patient with chronic myeloid leukaemia
Publication Year: 2025 Source: BMJ Case Rep PMID: 39755554
Dasatinib is a common treatment for chronic myeloid leukaemia with numerous side effects including gastrointestinal. We report a woman in her 50s who presented with haematochezia, weight loss and a positive faecal occult blood test. She was being treated for chronic myeloid leukaemia with dasatinib without the use of any …
Retrospective Cohort Study on the Predictive Value of Primary Non-response to Initial Biologic for Future Biologic Use in Patients with Inflammatory Bowel Disease
Publication Year: 2025 Source: Dig Dis Sci PMID: 39755922 DOI: 10.1007/s10620-024-08816-9
BACKGROUND: The armamentarium of medical therapies to treat inflammatory bowel disease (IBD) continues to grow, which has expanded treatment options, particularly after first biologic failure. Currently, there are limited studies investigating the predictive value of first biologic primary non-response (PNR) on subsequent biologic success. Our objective was to determine if …
A new protocolized treatment strategy optimizing medical and surgical care leads to improved healing of Crohn's perianal fistulas
Publication Year: 2025 Source: J Crohns Colitis PMID: 39756400
BACKGROUND AND AIMS: Crohn's perianal fistula healing rates remain low. We evaluated the efficacy of a protocolized multidisciplinary treatment strategy optimizing care in adults with Crohn's perianal fistulas. METHODS: A new treatment strategy was established at a single tertiary center. The strategy comprised 3 dynamic stages of care directed toward …
Impact of prescribing vancomycin capsules vs liquid at discharge on readmissions for C. difficile infection
Publication Year: 2025 Source: Am J Health Syst Pharm PMID: 39756415
PURPOSE: Clostridioides difficile infection (CDI) is a hospital-acquired infection commonly treated with oral vancomycin. An institutional policy aimed at reducing costs by substituting compounded liquid vancomycin for capsules may have the unintended consequence of having the liquid formulation prescribed at discharge, potentially delaying patients' access due to a lack of …
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