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Multi-omics data integration identifies novel biomarkers and patient subgroups in inflammatory bowel disease
Publication Year: 2025 Source: J Crohns Colitis PMID: 39756419 DOI: 10.1093/ecco-jcc/jjae197
BACKGROUND: Inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), is a complex condition with diverse manifestations; recent advances in multi-omics technologies are helping researchers unravel its molecular characteristics to develop targeted treatments. OBJECTIVES: In this work, we explored one of the largest multi-omics cohorts in IBD, …
Pregnancy With a Stoma is Feasible, Though Associated With Manageable Complications
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39756433 DOI: 10.1093/ibd/izae301
BACKGROUND: Inflammatory bowel disease (IBD) is often diagnosed in young adults, and therefore frequently coincides with pregnancy. Patients may require surgery that includes (temporary) stoma placement. Literature on the occurrence of stoma-complications during pregnancy and the effect on pregnancy outcomes is limited. To evaluate stoma- complications peri- and postpartum, a …
A Similar Mutation in the AAUU-Rich Elements of the Mouse TNF Gene Results in a Distinct Ileocolitic Phenotype: A New Strain of TNF-Overexpressing Mice
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39756463 DOI: 10.1093/ibd/izae307
BACKGROUND: Tumor necrosis factor (TNF) is a pleiotropic cytokine that plays a critical role in the pathogenesis of immune-mediated diseases including inflammatory bowel disease (IBD). The stability of its mRNA transcript, determined in part by destabilizing sequences in its AAUU repeats (ARE) gene region, is an important regulator of its …
Tofacitinib Mitigates the Increased SARS-CoV-2 Infection Susceptibility Caused by an IBD Risk Variant in the PTPN2 Gene
Publication Year: 2025 Source: Cell Mol Gastroenterol Hepatol PMID: 39756517
BACKGROUND & AIMS: Coronavirus disease (COVID-19), caused by severe acquired respiratory syndrome-Coronavirus-2 (SARS-CoV-2), triggered a global pandemic with severe medical and socioeconomic consequences. Although fatality rates are higher among the elderly and those with underlying comorbidities, host factors that promote susceptibility to SARS-CoV-2 infection and severe disease are poorly understood. …
Twin Pregnancies in Inflammatory Bowel Disease Are Associated With Increased Adverse Outcomes
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 39756771 DOI: 10.1016/j.cgh.2024.12.005
No Abstract
Inflammatory bowel disease, MASLD, and cardiometabolic risks: Unveiling a new perspective on mortality risk
Publication Year: 2025 Source: Dig Liver Dis PMID: 39757065
No Abstract
Anti-inflammatory, anti-colitis, and antioxidant effects of columbianadin against DSS-induced ulcerative colitis in rats via alteration of HO-1/Nrf2 and TLR4-NF-κB signaling pathway
Publication Year: 2025 Source: Inflammopharmacology PMID: 39757276 DOI: 10.1007/s10787-024-01630-9
BACKGROUND: Ulcerative colitis (UC) is a significant inflammatory bowel disease (IBD) that typically arises from chronic inflammation of the intestinal tract. Report suggest that anti-inflammatory drug plays a crucial role in the protection of UC. The recent study demonstrated that columbianadin has a protective effect against UC induced by dextran …
Role of 5-aminosalicylic acid in ulcerative colitis management in 8 Asian territories: a physician survey
Publication Year: 2025 Source: Intest Res PMID: 39757455
Clinical guidelines typically endorse conventional therapies such as 5-aminosalicylic acid (5-ASA) as the mainstay of ulcerative colitis management. However, the degree of adoption and application of guideline recommendations by physicians within Asia remains unclear. This study aims to understand the prescribing patterns of 5-ASA and implementation of current guideline recommendations …
A Simple Endoscopic Score for Crohn's Disease (SES-CD) ≥ 7 Predicts Disease Progression
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 39757503
BACKGROUND: Up to 30% of patients with Crohn's disease (CD) will experience a mild disease course. However, there is no consensus definition for mild CD. AIM: To examine the Simple Endoscopic Score for Crohn's disease (SES-CD) thresholds best associated with low likelihood of long-term disease progression. METHODS: We conducted a …
Management of Perianal Fistulizing Crohn's Disease According to Principles of Wound Repair
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 39757535
BACKGROUND: Perianal fistulizing Crohn's disease (PFCD) is a challenging and debilitating phenotype of Crohn's disease that can negatively affect quality of life. Studies have begun to uncover the physiologic mechanisms involved in wound repair as it relates to PFCD and how aberrations in these mechanisms may contribute to fistula persistence. …
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