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Rare Finding of Rectal Squamous Metaplasia in Inflammatory Bowel Disease
Publication Year: 2025 Source: ACG Case Rep J PMID: 39829945
Rectal squamous metaplasia in inflammatory bowel disease is rare. We present 2 cases of rectal squamous metaplasia, one in a patient with Crohn's disease and another with ulcerative colitis. Given the risk of malignant transformation, dysplasia surveillance is important particularly in areas of chronic inflammation. Furthermore, human papilloma virus (HPV) …
Examination of non-conventional dysplasias adjacent to colorectal adenocarcinoma in patients with IBD
Publication Year: 2025 Source: Pathol Oncol Res PMID: 39831270 DOI: 10.3389/pore.2024.1611978
OBJECTIVE: Recently, several non-conventional variants of IBD-associated dysplasia have been described; however, their prevalence in Central-Eastern Europe is unknown. We aimed to perform a retrospective pilot study by re-evaluating several IBD-associated adenocarcinoma cases to survey the incidence of adjacent non-conventional dysplasia and validate that recent North American findings may apply …
Formulation, optimisation, and evaluation of Lornoxicam-loaded Novasomes for targeted ulcerative colitis therapy: in vitro and in vivo investigations
Publication Year: 2025 Source: J Drug Target PMID: 39831638
The purpose of this work was to create and assess Lornoxicam (LOR) loaded Novasomes (Novas) for the efficient treatment of ulcerative colitis. The study was performed using a 2(3) factorial design to investigate the impact of several formulation variables. Three separate parameters were investigated: Surface Active agent (SAA) type (X(1)), …
Helicobacter pylori infection is associated with significant elevations to fecal calprotectin, systemic inflammatory markers
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 39831651 DOI: 10.1002/jpn3.12464
OBJECTIVES: Fecal calprotectin (FC) is a marker commonly used in the diagnosis and follow-up of inflammatory bowel diseases (IBD). However, other gastrointestinal conditions, like H. pylori (HP) infection, can result in increased neutrophil activity as well. We set out to assess the impact of HP infection on FC and downstream …
Gasdermin B modulates intestinal epithelial homeostasis via regulating hyperactive unfolded protein response in Crohn's disease
Publication Year: 2025 Source: J Crohns Colitis PMID: 39831701 DOI: 10.1093/ecco-jcc/jjaf012
BACKGROUND: Impaired intestinal epithelial barrier has been considered to be associated with an increasing variety of gastrointestinal diseases, especially inflammatory bowel disease (IBD) encompassing Crohn's disease (CD) and ulcerative colitis (UC). We aimed to investigate the role of Gasdermin B (GSDMB) in modulating intestinal epithelial barrier integrity and proposed a …
Laparoscopic robotic-assisted ileo-caecal resection with intracorporeal anastomosis in children with Crohn disease: initial experience of a paediatric center and surgical feasibility
Publication Year: 2025 Source: Pediatr Surg Int PMID: 39831981 DOI: 10.1007/s00383-024-05961-0
PURPOSE: Pediatric-onset Crohn's disease (CD) presents with a more aggressive course than adults. Surgical treatment is still necessary in many patients. The laparoscopic technique for treating terminal ileal CD is deemed safe and feasible, with the advantage to perform an intra-corporeal anastomosis (ICA). The robotic platform facilitates ICA creation thanks …
Emerging Connections Between Inflammatory Bowel Disease Subtypes and Sequential Changes in Total Serum Bilirubin
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39832261 DOI: 10.1093/ibd/izaf004
No Abstract
Geographical and Socioeconomic Disparities in Substance and Opioid Use Disorders Among Inflammatory Bowel Disease Hospitalizations in the United States From the National Inpatient Sample
Publication Year: 2025 Source: J Clin Psychiatry PMID: 39832310 DOI: 10.4088/JCP.24m15339
Objective: We compared substance use disorder (SUD) prevalence among adult inflammatory bowel disease (IBD) hospitalizations with non-IBD controls from the 2016-2018 National Inpatient Sample, assessing correlations with demographics, socioeconomic status, geographic regions, depression, and anxiety. Methods: The primary aim focused on SUD, defined as substance abuse or dependence (International Statistical …
Relevance of mouse and human IBD patient-derived colon organoids to investigate intestinal macrophage differentiation
Publication Year: 2025 Source: J Leukoc Biol PMID: 39832522 DOI: 10.1093/jleuko/qiaf004
The gastrointestinal tract is a remarkable example of complex biology, with a constant dialogue between the intestinal epithelium, in close contact with the microbiota, and the immune cells that protect the gut from infection. Organoids have revolutionized our approach to modeling the intestinal cellular compartment and have opened new avenues …
Laparoscopic endoscopic cooperative surgery for fixed and folded rectal stricture in a patient with Crohn's disease
Publication Year: 2025 Source: Gastrointest Endosc PMID: 39832559
No Abstract
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