Research Articles Library
Literature Analysis Tools
Advanced Search
Filter by PMID, year, source, DOI and other criteria
Literature Analysis
Analyze research trends and hotspots
Batch Export
Export search results to Excel/PDF
Identifying Novel Inflammatory Protein Biomarkers and Drug Targets of Inflammatory Bowel Disease by Integrating Mendelian Randomization, Bioinformatics, and Druggability Analysis
Publication Year: 2025 Source: Int Arch Allergy Immunol PMID: 39827860 DOI: 10.1159/000543259
INTRODUCTION: Inflammatory proteins have the potential to be used as therapeutic targets for inflammatory bowel disease (IBD). METHODS: We conducted Mendelian randomization (MR) analysis to probe causal associations between 91 circulating inflammatory proteins and IBD in the discovery and replication cohorts. Subsequently, we conducted meta-analysis of results from two cohorts. …
Exploring the utility of cellular indices in the diagnosis of ulcerative colitis
Publication Year: 2025 Source: Gastroenterol Hepatol PMID: 39827908
AIM: To describe the usefulness of cellular indices in the diagnosis of ulcerative colitis (UC). METHODS: Diagnostic study of patients under 15 years of age undergoing colonoscopy+/-esophagogastroduodenoscopy for suspected inflammatory bowel disease between 2015 and 2022 in a pediatric hospital. Patients with normal biopsy and anatomopathological diagnosis of UC were …
Long-Term Risk of Inflammatory Bowel Disease With MASLD: A Large-Scale Prospective Cohort Study in UK Biobank
Publication Year: 2025 Source: J Gastroenterol Hepatol PMID: 39828371 DOI: 10.1111/jgh.16880
BACKGROUND: Similar worsening epidemics globally have been showed in newly coined metabolic dysfunction-associated steatotic liver disease (MASLD) and inflammatory bowel disease (IBD). We aimed to investigate the prospective association of MASLD, MASLD types, and cardiometabolic risk factors (CMRFs) with long-term risk of incident IBD in a large-scale population cohort. METHODS: …
Author's reply: "Inflammatory bowel disease, MASLD, and cardiometabolic risks: Unveiling a new perspective on mortality risk"
Publication Year: 2025 Source: Dig Liver Dis PMID: 39828439
No Abstract
Histological healing in IBD: Ready for prime time?
Publication Year: 2025 Source: Dig Liver Dis PMID: 39828441 DOI: 10.1016/j.dld.2025.01.039
The main target of treatment in ulcerative colitis and Crohn's disease is to achieve a complete so-called mucosal healing. Various definitions of mucosal healing are available in literature, and the most recent ones include a combination of endoscopic and histological remission. However, the assessment of a complete histological remission is …
Clinical features, treatment, and prognosis of secukinumab-induced inflammatory bowel disease
Publication Year: 2025 Source: Eur J Med Res PMID: 39828702 DOI: 10.1186/s40001-025-02295-y
BACKGROUND: Inflammatory bowel disease (IBD) is a rare adverse effect linked to secukinumab, with limited clinical data available. This study aimed to analyze the clinical features of secukinumab-induced IBD and to offer recommendations for the careful administration of secukinumab. METHODS: We conducted a retrospective analysis by gathering case reports and …
Risk factors for stoma and incision complications of enterostomy in children with very early-onset inflammatory bowel disease: a prospective cohort study
Publication Year: 2025 Source: Eur J Pediatr PMID: 39828783 DOI: 10.1007/s00431-024-05952-2
Enterostomy is utilized to mitigate severe clinical symptoms in children with very early-onset inflammatory bowel disease (VEO-IBD) and to provide a window for stem cell transplantation. Nevertheless, the incidence of postoperative complications is significant, and there is currently a lack of research exploring the risk factors associated with complications related …
Post-secondary education in young patients with inflammatory bowel disease: A population-based cohort study
Publication Year: 2025 Source: Acta Paediatr PMID: 39829093 DOI: 10.1111/apa.17571
AIM: Inflammatory bowel disease (IBD) diagnosed in adolescence may have adverse effects on educational attainment. The study aims to examine post-secondary educational attainment in patients with IBD and how it is affected by disease severity and comorbid mental health disorders. METHODS: This cohort study used nationwide Danish registries. In a …
The Colonic Vitamin D Receptor and Inflammatory Bowel Disease: No Correlation to Histologic or Endoscopic Inflammation
Publication Year: 2025 Source: APMIS PMID: 39829252 DOI: 10.1111/apm.70000
The role of the vitamin D receptor (VDR) in inflammatory bowel disease (IBD) is poorly described. The aim of this study was to examine the relationship between immunohistochemical VDR expression and IBD activity. The immunohistochemical expression of VDR was analysed in biopsies from active and inactive IBD in 28 patients …
Fast simulation of identity-by-descent segments
Publication Year: 2025 Source: bioRxiv PMID: 39829821 DOI: 10.1101/2024.12.13.628449
The worst-case runtime complexity to simulate haplotype segments identical by descent (IBD) is quadratic in sample size. We propose two main techniques to reduce the compute time, both of which are motivated by coalescent and recombination processes. We provide mathematical results that explain why our algorithm should outperform a naive …
Need more literature?
The current database contains 98453 research articles. If you need to search for more literature or perform AI analysis, please use our knowledge acquisition module or explore external literature resources.
External Resources: Access comprehensive literature databases worldwide