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AhR Activation Transcriptionally Induces Anti-Microbial Peptide Alpha-Defensin 1 Leading to Reversal of Gut Microbiota Dysbiosis and Colitis
Publication Year: 2025 Source: Gut Microbes PMID: 39894796
Alpha-defensin 1 is a small antimicrobial peptide that acts as the first line of defense against pathogens. It is induced following microbial cues and inflammatory signals in neutrophils and Paneth cells in the small intestine, which suggests that it plays a role in microbial homeostasis in the gut. The gut …
Serotonin attenuates tumor necrosis factor-induced intestinal inflammation by interacting with human mucosal tissue
Publication Year: 2025 Source: Exp Mol Med PMID: 39894823
The intestine hosts the largest immune system and peripheral nervous system in the human body. The gut‒brain axis orchestrates communication between the central and enteric nervous systems, playing a pivotal role in regulating overall body function and intestinal homeostasis. Here, using a human three-dimensional in vitro culture model, we investigated …
Review Article: Albumin and Its Role in Inflammatory Bowel Disease: The Old, the New, and the Future
Publication Year: 2025 Source: J Gastroenterol Hepatol PMID: 39894941 DOI: 10.1111/jgh.16895
BACKGROUND: Circulating albumin concentrations are frequently measured in clinical practice. This review explores biochemical properties and physiological roles of albumin, its place in nutritional assessment, current understanding of perturbed circulating concentrations, and role in clinical management, with special focus on patients with inflammatory bowel disease (IBD). METHODS: A detailed literature …
Tofacitinib for the treatment of chronic pouchitis: A pilot study
Publication Year: 2025 Source: United European Gastroenterol J PMID: 39895228
BACKGROUND & AIMS: Up to 15% of ulcerative colitis (UC) patients with an ileo-anal pouch will develop chronic or antibiotic refractory pouchitis. We aimed to evaluate the efficacy and safety of tofacitinib in these refractory patients. METHODS: In this prospective single center study, adult UC patients with chronic or antibiotic …
Lactobacillus rhamnosus GG induces STING-dependent IL-10 in intestinal monocytes and alleviates inflammatory colitis in mice
Publication Year: 2025 Source: J Clin Invest PMID: 39895628
Preclinical and clinical observations indicate that the probiotic Lactobacillus rhamnosus GG (LGG) can modulate colonic inflammation. However, the underlying mechanisms have not been explored in depth. Here, we demonstrate that oral administration of live LGG alleviated inflammatory colitis by increasing IL-10 expression in intestinal Ly6C+ monocytes. Mechanistically, LGG induced IL-10 …
The association between serum zinc level and clinical features in patients with inflammatory bowel disease
Publication Year: 2025 Source: J Clin Biochem Nutr PMID: 39896166
No Abstract
Dietary protein source mediates colitis pathogenesis through bacterial modulation of bile acids
Publication Year: 2025 Source: bioRxiv PMID: 39896483 DOI: 10.1101/2025.01.24.634824
Evidence-based dietary recommendations for individuals with inflammatory bowel diseases (IBD) are limited. Red meat consumption is associated with increased IBD incidence and relapse in patients, suggesting that switching to a plant-based diet may limit gut inflammation. However, the mechanisms underlying the differential effects of these diets remain poorly understood. Feeding …
Antimicrobial peptide DP7 alleviates dextran sulfate sodium (DSS)-induced colitis via modifying gut microbiota and regulating intestinal barrier function
Publication Year: 2025 Source: MedComm (2020) PMID: 39896755 DOI: 10.1002/mco2.70085
Inflammatory bowel diseases (IBDs), such as Crohn's disease (CD) and ulcerative colitis (UC), represent a growing global health concern. Restoring the balance of the gut microbiota, a crucial factor in intestinal health, offers potential for treating IBD. DP7, a novel antimicrobial peptide with potent antibacterial activity, was investigated for its …
GEMCAT-a new algorithm for gene expression-based prediction of metabolic alterations
Publication Year: 2025 Source: NAR Genom Bioinform PMID: 39897103
The interpretation of multi-omics datasets obtained from high-throughput approaches is important to understand disease-related physiological changes and to predict biomarkers in body fluids. We present a new metabolite-centred genome-scale metabolic modelling algorithm, the Gene Expression-based Metabolite Centrality Analysis Tool (GEMCAT). GEMCAT enables integration of transcriptomics or proteomics data to predict …
Exploring Glucagon-Like Peptide-1 Receptor Agonist Use in Inflammatory Bowel Disease Patients
Publication Year: 2025 Source: Gastroenterol Hepatol (N Y) PMID: 39897337
No Abstract
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