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Precision therapeutics for inflammatory bowel disease: advancing ROS-responsive nanoparticles for targeted and multifunctional drug delivery
Publication Year: 2025 Source: J Mater Chem B PMID: 39905851 DOI: 10.1039/d4tb02868f
Inflammatory bowel disease (IBD) is a severe chronic intestinal disorder with a rising global incidence. Current therapies, including the delivery of anti-inflammatory drugs and probiotics, face significant challenges in terms of safety, stability, and efficacy. In IBD patients, the activity of antioxidant enzymes (e.g., superoxide dismutase, glutathione peroxidase, and glutathione …
Glepaglutide-Loaded Foam for the Induction of Mucosal Healing in the Treatment of Inflammatory Bowel Disease
Publication Year: 2025 Source: Adv Healthc Mater PMID: 39905897
Glucagon-like peptide 2 (GLP-2) stimulates intestinal growth, repairs mucosa, and enhances epithelial integrity but has a short half-life (7 min). Glepaglutide (GL), a GLP-2 analog with an extended half-life (50 h), is currently undergoing clinical trials for patients with short bowel syndrome. GL requires subcutaneous injection, which poses challenges for …
Effect of Feeding Human Milk on Development of the Infant Immune System and Allergic Outcomes-An Area of Research Challenge and Need
Publication Year: 2025 Source: Breastfeed Med PMID: 39905904
Surprisingly little is known about the effect of breastfeeding on the infant's immune system development. Systematic reviews have suggested the role of breastfeeding in the prevention against asthma, autoimmune diseases, inflammatory bowel disease, and childhood leukemia. However, studies on atopic disease suffer from reverse causation, small size, and those assessing …
Causal Exposures in Pancreatic Cancer Incidence: Insights From Mendelian Randomization Studies
Publication Year: 2025 Source: JGH Open PMID: 39906083
AIM: Pancreatic cancer, marked by its high lethality and poor 5-year survival rate, requires a thorough understanding of its risk factors and etiological mechanisms. In this review, we collected the latest findings from Mendelian randomization (MR) studies to identify potential causal factors for pancreatic cancer. METHOD AND RESULTS: The present …
Cucurbitacin IIa Alleviates Colitis via Promoting the Release of Host-Derived Extracellular Vesicles Encapsulating microRNA-30b-5p
Publication Year: 2025 Source: J Inflamm Res PMID: 39906136
PURPOSE: Cucurbitacins have demonstrated anti-inflammatory effects and show promise for inflammatory bowel diseases. However, the underlying mechanisms by which cucurbitacins affect colitis remain largely unknown. METHODS: In this study, we investigated the impact of cucurbitacin IIa on dextran sulfate sodium (DSS)-induced colitis in rats and the alterations in intestinal extracellular …
Prevalence and predictors of small intestinal bacterial overgrowth in inflammatory bowel disease: a meta-analysis
Publication Year: 2025 Source: Front Med (Lausanne) PMID: 39906350 DOI: 10.3389/fmed.2024.1490506
BACKGROUND: Small intestinal bacterial overgrowth (SIBO) has been reported to be very common among individuals with inflammatory bowel disease (IBD), and the prevalence of SIBO is highly variable. We conducted this study to calculate the prevalence and identify predictors of SIBO in IBD. METHODS: PubMed, Cochrane Library, and EMBASE from …
Predictors for Chronic Opioid Use in Patients With Inflammatory Bowel Disease: A Population-Based Cohort Study
Publication Year: 2025 Source: Am J Gastroenterol PMID: 39907246
INTRODUCTION: A significant proportion of patients with Crohn's disease (CD) and ulcerative colitis (UC) become opioid users, but data pertaining to predictors of chronic opioid use remain sparse. We examined predictors for chronic opioid use in CD/UC. METHODS: This is a nationwide cohort study based on Danish registries, comprising incident …
UNEXPECTED FINDINGS DURING LAPAROTOMY SURGERY AND URGENT SURGICAL INDICATIONS ARE ASSOCIATED WITH POSTOPERATIVE COMPLICATIONS IN PATIENTS WITH CROHN'S DISEASE
Publication Year: 2025 Source: Arq Bras Cir Dig PMID: 39907326
BACKGROUND: Patients undergoing Crohn's disease (CD) surgery may develop a higher rate of postoperative complications (POC) than other patients. AIMS: The aim of this study was to investigate factors determining POC in patients with CD undergoing urgent laparotomy. METHODS: This is a retrospective cohort study conducted on adult patients undergoing …
Predisposing conditions in patients with small intestinal adenocarcinomas in the Netherlands: A 20-year nationwide cohort study
Publication Year: 2025 Source: Int J Cancer PMID: 39907526 DOI: 10.1002/ijc.35354
Small intestinal adenocarcinomas (SIAs) are associated with predisposing conditions, including inflammatory bowel disease (IBD) and celiac disease, but also genetic syndromes such as Lynch syndrome (LS) and familial adenomatous polyposis (FAP). This nationwide cohort study investigated the incidence of genetic and non-genetic predisposing conditions in SIA and their influence on …
Onset of pouchitis after colectomy for ulcerative colitis: reducing the risk
Publication Year: 2025 Source: Expert Rev Gastroenterol Hepatol PMID: 39907581
INTRODUCTION: Pouchitis remains the most common complication after ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (IPAA). Despite the burden of pouchitis, our ability to recognize the patients at greatest risk for pouchitis and to offer early intervention for the prevention or early treatment is limited. AREAS COVERED: In this review, …
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