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Pyoderma Gangrenosum with Oral Involvement and Multidisciplinary Management
Publication Year: 2025 Source: J Maxillofac Oral Surg PMID: 39902420
No Abstract
Phillygenin ameliorates tight junction proteins reduction, fibrosis, and apoptosis in mice with chronic colitis via TGR5-mediated PERK-eIF2α-Ca(2+) pathway
Publication Year: 2025 Source: J Pharm Anal PMID: 39902458
No Abstract
Clinical evaluation of platelet-to-albumin ratio as a predictor of surgical site infection in pediatric patients with ulcerative colitis
Publication Year: 2025 Source: Surg Today PMID: 39903232
PURPOSE: This study explored the predictive factors for surgical site infection (SSI) in a pediatric ulcerative colitis (UC) population. METHODS: Data from 35 patients with UC who underwent surgery before 15 years at Mie University Hospital between January 2000 and December 2022 were retrospectively reviewed. Potential preoperative and intraoperative predictors …
HMGB1: key mediator in digestive system diseases
Publication Year: 2025 Source: Inflamm Res PMID: 39903246 DOI: 10.1007/s00011-025-02002-x
High Mobility Group Box 1 (HMGB1), a multifunctional non-histone protein, and its involvement in various physiological and pathological contexts has garnered significant attention. Given HMGB1's central function in modulating key biological activities, such as inflammatory responses and cellular death, its contribution to the pathogenesis of digestive system diseases has become …
Aesthetic benefit of single-port laparoscopic ileo-caecal resection for Crohn's disease: a comparative study
Publication Year: 2025 Source: Tech Coloproctol PMID: 39903360
BACKGROUND: Single-port laparoscopy has been mainly studied for colonic cancer or cholecystectomy. Little is known about the cosmetic outcome for patients with Crohn's disease who are the best candidates for single-port surgery. This study aimed to assess cosmetic outcomes with single-port laparoscopy (SPL) vs. multiport laparoscopy (MPL) after ileocolic resection …
Intestinal Ultrasound Identified Crohn's Disease In Previously Undiagnosed Siblings
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39903445
No Abstract
Machine learning and metabolomics identify biomarkers associated with the disease extent of ulcerative colitis
Publication Year: 2025 Source: J Crohns Colitis PMID: 39903649
BACKGROUND AND AIMS: Ulcerative colitis (UC) is a metabolism-related chronic intestinal inflammatory disease. Disease extent is a key parameter of UC. Using serum metabolic profiling to identify noninvasive biomarkers of disease extent may inform therapeutic decisions and risk stratification. METHODS: The orthogonal partial least squares-discriminant analysis (OPLS-DA) was performed to …
Therapeutic potential of tryptophan metabolite indoleacrylic acid in inflammatory bowel disease: From cellular mechanisms to zebrafish stress-like behavior
Publication Year: 2025 Source: Int Immunopharmacol PMID: 39904043 DOI: 10.1016/j.intimp.2025.114207
Inflammatory bowel disease (IBD) is a chronic condition associated with elevated rates of anxiety and depression and ultimately reduces the quality of life. Thus, preventive care addressing both physical and psychological health is essential. In this study we aimed to explore the protective effects of Indoleacrylic Acid (IA) against lipopolysaccharide …
Single-cell omics in inflammatory bowel disease: recent insights and future clinical applications
Publication Year: 2025 Source: Gut PMID: 39904604 DOI: 10.1136/gutjnl-2024-334165
Inflammatory bowel diseases (IBDs), which include ulcerative colitis (UC) and Crohn's disease (CD), are chronic conditions characterised by inflammation of the intestinal tract. Alterations in virtually all intestinal cell types, including immune, epithelial and stromal cells, have been described in these diseases. The study of IBD has historically relied on …
Crohn's Disease With Latent Tuberculosis Infection or Intestinal Tuberculosis: Rapid Discrimination by Targeted Next-Generation Sequencing
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 39905821
BACKGROUND: Discriminating Crohn's disease (CD) with latent tuberculosis infection (LTBI) from intestinal tuberculosis (ITB) in tuberculosis-endemic regions remains challenging. AIM: To assess whether targeted next-generation sequencing (tNGS) could be an efficient method for ITB diagnosis and discrimination from CD with LTBI. METHODS: The study was conducted prospectively from September 2020 …
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