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Identification of the immune infiltration and biomarkers in ulcerative colitis based on liquid-liquid phase separation-related genes
Publication Year: 2025 Source: Sci Rep PMID: 39915583
Liquid-liquid phase separation (LLPS) associates with immune infiltration in multiple diseases. Nonetheless, the role of LLPS-related genes (LLPS-RGs) in immune infiltration of ulcerative colitis (UC) is still elusive. We identified the hub LLPS-RGs (DE-LLPS-RGs) (HSPB3, SLC16A1, TRIM22, SRI, PLEKHG6, GBP1, PADI2) by machine learning algorithms. Hub genes were screened that …
A foundation systematic review of natural language processing applied to gastroenterology & hepatology
Publication Year: 2025 Source: BMC Gastroenterol PMID: 39915703
OBJECTIVE: This review assesses the progress of NLP in gastroenterology to date, grades the robustness of the methodology, exposes the field to a new generation of authors, and highlights opportunities for future research. DESIGN: Seven scholarly databases (ACM Digital Library, Arxiv, Embase, IEEE Explore, Pubmed, Scopus and Google Scholar) were …
Elucidating the association between nonalcoholic fatty liver disease and incidence of inflammatory bowel disease: a focus on systemic inflammation
Publication Year: 2025 Source: Intest Res PMID: 39916480
No Abstract
Helminths in alternative therapeutics of inflammatory bowel disease
Publication Year: 2025 Source: Intest Res PMID: 39916482 DOI: 10.5217/ir.2023.00059
Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is a nonspecific chronic inflammation of the gastrointestinal tract. Despite recent advances in therapeutics and newer management strategies, IBD largely remains untreatable. Helminth therapy is a promising alternative therapeutic for IBD that has gained some attention in the last …
Clinical Features of Thiopurine-Induced Acute Pancreatitis: Comparison Between Patients With and Without Inflammatory Bowel Disease
Publication Year: 2025 Source: Crohns Colitis 360 PMID: 39917028 DOI: 10.1093/crocol/otae072
BACKGROUND AND AIMS: Patients with inflammatory bowel disease (IBD) are at increased risk of developing acute pancreatitis (AP). Thiopurines (TP) are a well-known cause of AP. The aims of this study were to compare the incidence of AP and TP-induced AP (TIP) between patients with and without IBD under the …
The Natural History of Inflammatory Bowel Disease in Adults With Common Variable Immunodeficiency: A Case Series From a Single US Tertiary Care Center
Publication Year: 2025 Source: Crohns Colitis 360 PMID: 39917029 DOI: 10.1093/crocol/otae062
BACKGROUND: Common variable immunodeficiency (CVID) predisposes patients to inflammatory bowel disease (IBD). There are limited studies characterizing adults with concomitant CVID and IBD (CVID-IBD). METHODS: Demographics, clinical courses, endoscopic findings, and disease-specific therapies were obtained in adults >/=18 years with CVID-IBD over a 5-year period. RESULTS: We identified 11 patients …
Real-world assessment of effectiveness and safety of filgotinib in 286 patients with ulcerative colitis in 9 UK centres
Publication Year: 2025 Source: Drugs Context PMID: 39917051
BACKGROUND: Filgotinib, an oral Janus kinase 1 preferential inhibitor, has been shown to be an effective treatment for ulcerative colitis (UC) in pre-registration studies. We aimed to describe the treatment population, effectiveness and safety of filgotinib in a real-world cohort of patients with UC. METHODS: A retrospective observational cohort evaluation …
The Efficacy of the Low-FODMAP (Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols) Diet in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis
Publication Year: 2025 Source: Cureus PMID: 39917138
Irritable bowel syndrome (IBS) is frequently observed in clinical practice and affects people from different parts of the world. The pathogenesis and aetiology are not well-defined or fully understood; however, altered bowel movements, psychological factors, and visceral hypersensitivity may contribute to symptoms via a pathway mediated by serotonin and other …
Exploring genetic structures and shared sites between alcohol, cheese intake, and inflammatory bowel disease
Publication Year: 2025 Source: Front Nutr PMID: 39917747 DOI: 10.3389/fnut.2025.1468457
BACKGROUND: An association has been observed between alcohol and cheese intake and the onset of inflammatory bowel disease (IBD), necessitating further exploration from a genetic structural perspective. METHODS: The present analysis was focused on the intake of alcohol and cheese in conjunction with IBD genome-wide association study (GWAS) data, with …
Candida tropicalis Alters Barrier Permeability and Claudin-1 Organization in Intestinal Epithelial Cells
Publication Year: 2025 Source: J Physiol Investig PMID: 39918057 DOI: 10.4103/ejpi.EJPI-D-24-00090
Inflammatory bowel disease (IBD) is an autoimmune disorder characterized by chronic inflammation of the gut and compromised intestinal barrier function, resulting from aberrant immune responses targeting the intestinal microbiota. While the involvement of Candida albicans in IBD pathogenesis is well-documented, the role of non- albicans Candida species in IBD remains …
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