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Alterations in mucosa branched N-glycans lead to dysbiosis and downregulation of ILC3: a key driver of intestinal inflammation
Publication Year: 2025 Source: Gut Microbes PMID: 39918275 DOI: 10.1080/19490976.2025.2461210
The perturbation of the symbiotic relationship between microbes and intestinal immune system contributes to gut inflammation and Inflammatory Bowel Disease (IBD) development. The host mucosa glycans (glycocalyx) creates a major biological interface between gut microorganisms and host immunity that remains ill-defined. Glycans are essential players in IBD immunopathogenesis, even years …
A Role for Leucine-Rich α2-Glycoprotein in Leukocyte Trafficking and Mucosal Inflammation in Inflammatory Bowel Disease
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39918378 DOI: 10.1093/ibd/izaf022
BACKGROUND: Leucine-rich alpha2-glycoprotein (LRG) has been identified as a disease activity marker that reflects pathology of inflammatory diseases including inflammatory bowel disease (IBD). Whereas LRG was reported to modulate transforming growth factor beta-1 (TGF-beta) signaling, the role of LRG in inflammatory diseases has not been fully clarified. Here we investigated …
Letter to the Editor: Microscopic Colitis after Ocrelizumab for Multiple Sclerosis
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39918380
No Abstract
Causal effects of various particulate matter on inflammatory bowel disease and its subtypes: insights from Mendelian randomization
Publication Year: 2025 Source: Int J Biometeorol PMID: 39918593 DOI: 10.1007/s00484-025-02862-2
The role of particulate matter (PM) on genetic susceptibility to inflammatory bowel disease (IBD) is a controversial topic. The study aims to evaluate the causal effect of PM on IBD using Mendelian randomization (MR). PM and IBD datasets were screened for common single nucleotide polymorphisms (SNPs) based on the MR …
Ligand-Targeted Ag(9) Cluster Self-Cascade Antioxidants for Enhanced Reactive Oxygen Species Clearance in the Treatment of Inflammatory Bowel Disease
Publication Year: 2025 Source: Nano Lett PMID: 39918793 DOI: 10.1021/acs.nanolett.4c06440
Atomically precise metal nanoclusters (MNCs) with flexible peripheral ligands provide selective channels and unique electronic structures to the rigid metal core, showing great application potential in many fields such as biomimetic nanozymes. In this study, we developed cost-effective, low-toxicity, and water-soluble MNC based self-cascade antioxidants for enhanced reactive oxygen species …
Gastrointestinal pathologist consensus of revised high-grade dysplasia in inflammatory bowel disease impacts the advanced neoplasia rate: a multicenter study
Publication Year: 2025 Source: Eur J Gastroenterol Hepatol PMID: 39919003 DOI: 10.1097/MEG.0000000000002897
OBJECTIVE: The diagnosis of inflammatory bowel disease (IBD) associated with high-grade dysplasia (HGD) has a significant impact on clinical management, including colectomy. However, the prognosis of HGD remains unclear due to diagnostic uncertainty and low-quality data on subsequent synchronous and metachronous neoplasia. We aimed to evaluate a diagnostic strategy with …
Directionality of endoscopic and histologic healing in ulcerative colitis: a prospective pilot study
Publication Year: 2025 Source: Eur J Gastroenterol Hepatol PMID: 39919005
OBJECTIVE: Endoscopic and histologic healing in ulcerative colitis (UC) is hypothesized to progress proximally to distally, with healing of the distal rectosigmoid occurring last. However, this has not been empirically verified. METHODS: We performed a prospective cohort study in patients with pancolonic UC commencing treatment with a tumor necrosis factor …
Management of sporotrichosis in patients with inflammatory bowel disease using biological therapy (antitumor necrosis factor)
Publication Year: 2025 Source: Eur J Gastroenterol Hepatol PMID: 39919009 DOI: 10.1097/MEG.0000000000002907
Antitumor necrosis factor (TNF)-alpha (TNFa) drugs are crucial for treating inflammatory bowel disease (IBD) but may increase opportunistic infection risk. Among such infections, sporotrichosis is a chronic granulomatous disease caused by saprophytic dimorphic fungi of the genus Sporothrix, which occurs worldwide. To date, there have been no reports of sporotrichosis …
Inflammatory bowel diseases patients' perspective on the impact of pathologic evaluation: an 'AMICI' initiative
Publication Year: 2025 Source: Eur J Gastroenterol Hepatol PMID: 39919010
No Abstract
MAIT cell homing in intestinal homeostasis and inflammation
Publication Year: 2025 Source: Sci Adv PMID: 39919191 DOI: 10.1126/sciadv.adu4172
Mucosa-associated invariant T (MAIT) cells are a large population of unconventional T cells widely distributed in the human gastrointestinal tract. Their homing to the gut is central to maintaining mucosal homeostasis and immunity. This review discusses the potential mechanisms that guide MAIT cells to the intestinal mucosa during homeostasis and …
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