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Psychotherapy process variables in implementation of CBT for inflammatory bowel disease:Therapist competence, fidelity, and patient themes
Publication Year: 2025 Source: Behav Res Ther PMID: 39919362 DOI: 10.1016/j.brat.2025.104702
OBJECTIVE: Inflammatory Bowel Diseases (IBD) are a group of chronic immune-mediated digestive disorders that can cause significant psychological distress and disability. IBD-informed cognitive behavioral therapy (CBT) may reduce psychiatric co-morbidity and improve health related quality of life. We herein examine the psychotherapy process variables relevant to implementation of a manualized …
Overcoming the challenges of overtreating and undertreating inflammatory bowel disease
Publication Year: 2025 Source: Lancet Gastroenterol Hepatol PMID: 39919770 DOI: 10.1016/S2468-1253(24)00355-8
Several therapeutic advances have been achieved over the past two decades for inflammatory bowel disease (IBD). The expanding therapeutic armamentarium and the increasingly ambitious treatment targets have led to an increased use of advanced therapies and better outcomes. Nevertheless, many patients remain suboptimally treated and are at risk of disease …
Nano-targeted delivery system: a promising strategy of anthocyanin encapsulation for treating intestinal inflammation
Publication Year: 2025 Source: Crit Rev Food Sci Nutr PMID: 39919822
Anthocyanins are natural flavonoids derived from plants, widely recognized for their health-promoting effects, specifically to treat inflammatory bowel disease (Crohn's disease and ulcerative colitis). However, certain limitations are associated with their use, including instability, low solubility and permeability, poor gastrointestinal digestion, and low bioavailability. In this review, nano-carriers (e.g., liposome, …
Gut Microbiota-Mediated Degradation of Food-Grade Lambda-Carrageenan by Bacteroides xylanisolvens and Its Role in Inflammation
Publication Year: 2025 Source: J Agric Food Chem PMID: 39920146
Concerns about the safety of food additives have intensified among consumers, scientists, and policymakers. Ensuring the safety of these additives is crucial to public health. Carrageenan (CGN), a common additive in the food industry, has become the subject of controversy, particularly regarding whether it can be degraded in the gastrointestinal …
Novel anti-inflammatory properties of mannose oligosaccharides in the treatment of inflammatory bowel disease via LGALS3 modulation
Publication Year: 2025 Source: NPJ Biofilms Microbiomes PMID: 39920168 DOI: 10.1038/s41522-025-00648-3
This study investigates the role of Gum Arabic Mannose Oligosaccharides (GA-MOS) in modulating gut microbiota and alleviating symptoms of Inflammatory Bowel Disease (IBD). Employing both in vitro and in vivo models, we explored how GA-MOS influences microbial communities, particularly focusing on their capacity to enhance health-associated bacteria and reduce pathogenic …
Bariatric surgery and relevant comorbidities: a systematic review and meta-analysis
Publication Year: 2025 Source: Surg Endosc PMID: 39920373 DOI: 10.1007/s00464-025-11528-4
BACKGROUND: Obesity is a growing epidemic in the United States, and with this, has come an increasing volume of metabolic surgery operations. The ideal management of obesity-associated medical conditions surrounding these operations is yet to be determined. This review sought to investigate the routine use of intraoperative cholangiogram (IOC) with …
Lymphocyte levels in Crohn's disease patients in clinical remission are significantly lower than those in healthy people
Publication Year: 2025 Source: Eur J Med Res PMID: 39920840 DOI: 10.1186/s40001-025-02352-6
BACKGROUND AND PURPOSE: Inflammatory bowel disease (IBD) is a chronic, non-specific inflammatory bowel disease caused by multiple causes. Lymphocytes migration is involved in the pathogenesis of IBD. The purpose of this study was to evaluate whether there were differences in blood lymphocytes levels between IBD patients in clinical remission and …
METTL14 modulates the progression and ferroptosis of colitis by regulating the stability of m6A-modified GPX4
Publication Year: 2025 Source: Eur J Med Res PMID: 39920858
Ulcerative colitis (UC) is non-specific inflammatory bowel disease. UC development and progression were closely associated with epigenetic modifications. Nevertheless, the specific relationship between N6-methyladenosine (m6A) modification at RNA transcription levels and UC pathogenesis remains unclear. We established UC cell models and mouse models through dextran sulfate sodium (DSS) induction. The …
Melezitose inhibited glycolytic pathway and enhances anti-Crohn's disease activity via binding to PGK1
Publication Year: 2025 Source: J Ethnopharmacol PMID: 39920914
ETHNOPHARMACOLOGY RELEVANCE: Alhagi honey is a light yellow sugar granule formed by concentrating the liquid secreted by Alhagi branches and leaves. It is a traditional Uygur medicine often used to treat abdominal pain, diarrhea, dysentery, and other conditions. Modern research has indicated that the main active components of Alhagi honey …
Mitochondrial damage-associated molecular patterns: New perspectives for mitochondria and inflammatory bowel diseases
Publication Year: 2025 Source: Mucosal Immunol PMID: 39920995 DOI: 10.1016/j.mucimm.2025.01.013
Mitochondria are key regulators of inflammatory responses and mitochondrial dysfunction is closely linked to various inflammatory diseases. Increasing genetic and experimental evidence suggests that mitochondria play a critical role in inflammatory bowel disease (IBD). In the complex environment of the intestinal tract, intestinal epithelial cells (IECs) and their mitochondria possess …
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