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Dysplasia screening in inflammatory bowel disease patients: to whom, when and how
Publication Year: 2025 Source: Gastroenterol Hepatol PMID: 39922457
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Comparison of time-to-event machine learning models in predicting biliary complication and mortality rate in liver transplant patients
Publication Year: 2025 Source: Sci Rep PMID: 39922959 DOI: 10.1038/s41598-025-89570-4
Post-Liver transplantation (LT) survival rates stagnate, with biliary complications (BC) as a major cause of death. We analyzed longitudinal data with a median 19-month follow-up. BC was diagnosed with ultrasounds and MRCP. Missing data was imputed using mean and median. Data preprocessing involved feature scaling and one-hot encoding. Survival analysis …
Risk factors for Clostridioides difficile infection among patients diagnosed with inflammatory intestinal and rheumatological diseases in the biologic era
Publication Year: 2025 Source: BMC Gastroenterol PMID: 39923011 DOI: 10.1186/s12876-025-03650-3
BACKGROUND: Clostridioides difficile infection (CDI) in inflammatory bowel disease (IBD) has been associated with poor clinical outcomes. The relationship between biologic therapy and CDI is controversial. We aimed to assess whether biologic therapy increases CDI risk among IBD patients, to identify factors associated with increased CDI risk, and to characterize …
Inflammation-targeted delivery of probiotics for alleviation of colitis and associated cognitive disorders through improved vitality and colonization
Publication Year: 2025 Source: Biomaterials PMID: 39923539
Oral probiotic biotherapies hold significant promise for addressing intestinal inflammatory disorders. Nonetheless, due to the challenging pathological microenvironment of the gastrointestinal tract, it is difficult to achieve deliver probiotics in an inflammation-targeted manner while improving their intestinal colonization and minimizing the impact of gastrointestinal environment on their vitality. To address …
Neolithic introgression of IL23R-related protection against chronic inflammatory bowel diseases in modern Europeans
Publication Year: 2025 Source: EBioMedicine PMID: 39923740 DOI: 10.1016/j.ebiom.2025.105591
BACKGROUND: The hypomorphic variant rs11209026-A in the IL23R gene provides significant protection against immune-related diseases in Europeans, notably inflammatory bowel diseases (IBD). Today, the A-allele occurs with an average frequency of 5% in Europe. METHODS: This study comprised 251 ancient genomes from Europe spanning over 14,000 years. In these samples, …
Effect of oral Mn-based nanozymes Mn(3)O(4) NPs on morphological, antioxidation, mucosa, and fecal microbial community in mice colons
Publication Year: 2025 Source: Food Chem Toxicol PMID: 39923832 DOI: 10.1016/j.fct.2025.115313
Mn(3)O(4) NPs, manganese-based nanoparticles with multienzyme-like antioxidative activity, have been widely used in anti-inflammatory, anti-tumor, and other related studies, especially those related to Inflammatory Bowel Disease (IBD). However, before formalizing these studies, it is important to assess their oral safety (especially intestinal) to understand its potential adverse effects on biological …
Inflammatory Bowel Disease and Dementia: Evidence Triangulation from a Meta-Analysis of Observational Studies and Mendelian Randomization Study
Publication Year: 2025 Source: Biomed Environ Sci PMID: 39924155 DOI: 10.3967/bes2024.149
OBJECTIVE: Observational studies have found associations between inflammatory bowel disease (IBD) and the risk of dementia, including Alzheimer's dementia (AD) and vascular dementia (VD); however, these findings are inconsistent. It remains unclear whether these associations are causal. METHODS: We conducted a meta-analysis by systematically searching for observational studies on the …
Uncovering de novo polyamine biosynthesis in the gut microbiome and its alteration in inflammatory bowel disease
Publication Year: 2025 Source: Gut Microbes PMID: 39924644 DOI: 10.1080/19490976.2025.2464225
Polyamines are important gut microbial metabolites known to affect host physiology, yet the mechanisms behind their microbial production remain incompletely understood. In this study, we developed a stable isotope-resolved metabolomic (SIRM) approach to track polyamine biosynthesis in the gut microbiome. Viable microbial cells were extracted from fresh human and mouse …
Click Chemistry-Based Bioconjugation of Iron Oxide Nanoparticles
Publication Year: 2025 Source: Small PMID: 39924809
Superparamagnetic iron oxide nanoparticles (SPIONs) exhibit unique properties for diverse biomedical applications, including drug delivery and diagnostic imaging. Actively targeted SPIONs enhance delivery to diseased sites, reducing side effects and enhancing treatment efficacy. However, the development of reproducible functionalization protocols is challenged by the erratic behavior of nanoparticles in suspensions, …
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