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A DNA Nanopatch-Bacteriophage System Targeting Streptococcus Gallolyticus for Inflammatory Bowel Disease Treatment and Colorectal Cancer Prevention
Publication Year: 2025 Source: Adv Mater PMID: 39924920 DOI: 10.1002/adma.202417334
Persistent inflammation in inflammatory bowel disease (IBD) increases Streptococcus gallolyticus (Sg) colonization, increasing the risk of colorectal cancer progression via the Sg-activated cyclooxygenase-2 (COX-2) pathway and beta-catenin upregulation. This study presents Sg-specific bacteriophages modified with DNA nanopatches (DNPs@P) designed to treat IBD and prevent Sg-induced malignancy. The DNPs are composed …
Carbon monoxide produced by HO-1 upregulation is the main factor behind the abnormal motility seen in experimental ulcerative colitis in mice
Publication Year: 2025 Source: Am J Physiol Gastrointest Liver Physiol PMID: 39925143
The colonic motility is altered in patients with ulcerative colitis (UC), but the mechanism is not clear. Carbon monoxide (CO) is the molecule regulating the resting membrane potential (RMP) gradient across colonic smooth muscle wall. Changes in RMP will affect the contractility of smooth muscle. In this study, we investigated …
Eosinophilic esophagitis associated with infliximab therapy in pediatric patients with inflammatory bowel disease
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 39925323
No Abstract
Classification of Nanomaterial Drug Delivery Systems for Inflammatory Bowel Disease
Publication Year: 2025 Source: Int J Nanomedicine PMID: 39925683 DOI: 10.2147/IJN.S502546
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, primarily arises from defects in the colonic barrier, imbalances of the gut microbiota, and immune response issues. These complex causes make it difficult to achieve a complete cure. Patients with IBD frequently experience recurrent abdominal pain and bloody diarrhea, while …
Omentin-1, a Protective Adipokine for Irritable Bowel Syndrome
Publication Year: 2025 Source: J Inflamm Res PMID: 39925934
INTRODUCTION: Irritable bowel syndrome (IBS) is characterized by patients' high level of suffering. There is increasing evidence for involvement of the immune system in this disease. Adipokines have been reported to be critical immunoregulators in many clinical conditions, including gastrointestinal (GI) inflammatory diseases. Our study aimed to investigate associations of …
Fucoidan alleviated colitis aggravated by fiber deficiency through protecting the gut barrier, suppressing the MAPK/NF-κB pathway, and modulating gut microbiota and metabolites
Publication Year: 2025 Source: Front Nutr PMID: 39925971 DOI: 10.3389/fnut.2024.1462584
Insufficient dietary fiber intake has become a global public health issue, affecting the development and management of various diseases, including intestinal diseases and obesity. This study showed that dietary fiber deficiency enhanced the susceptibility of mice to colitis, which could be attributed to the disruption of the gut barrier integrity, …
Risk factors for inflammatory bowel disease: an umbrella review
Publication Year: 2025 Source: Front Cell Infect Microbiol PMID: 39926114 DOI: 10.3389/fcimb.2024.1410506
INTRODUCTION: Inflammatory bowel disease (IBD) represents a cluster of chronic idiopathic inflammatory disorders situated at the nexus of intricate interplays. The primary aim of the present investigation is to perform an umbrella review of metaanalyses, systematically offering a comprehensive overview of the evidence concerning risk factors for IBD. METHODS: To …
Hollow cerium nanoparticles synthesized by one-step method for multienzyme activity to reduce colitis in mice
Publication Year: 2025 Source: World J Gastroenterol PMID: 39926211 DOI: 10.3748/wjg.v31.i5.98732
BACKGROUND: Inflammatory bowel disease (IBD) is a common chronic intestinal inflammatory disease. High oxidative stress is a treatment target for IBD. Cerium oxide (CeO(2)) nanomaterials as nanozymes with antioxidant activity are potential drugs for the treatment of colitis. AIM: To synthesize hollow cerium (H-CeO(2)) nanoparticles by one-step method and to …
Effect of Modulen vs budesonide on clinical response and mucosal healing in Crohn's patients
Publication Year: 2025 Source: World J Gastroenterol PMID: 39926225
BACKGROUND: Mucosal healing has become an important goal of Crohn's disease (CD) treatments. Modulen, enriched with transforming growth factor-beta 2, and budesonide are commonly accepted treatments for mild-moderate CD. However, their effects on the small bowel (SB) mucosa remain underexplored. AIM: To prospectively assess clinical and mucosal responses to Modulen …
New perspectives and prospects for the next generation of combination therapy in inflammatory bowel disease
Publication Year: 2025 Source: World J Gastroenterol PMID: 39926226 DOI: 10.3748/wjg.v31.i5.99462
This article comments on the letter by Lowell et al, which addresses the next generation of combination therapy for inflammatory bowel disease (IBD). As the understanding of the pathogenesis of IBD continues to improve, treatment strategies are evolving rapidly. The letter examines the current status and future directions of combination …
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