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Development of novel GI-centric prostaglandin E(2) receptor type 4 (EP4) agonist prodrugs as treatment for ulcerative colitis and other intestinal inflammatory diseases
Publication Year: 2025 Source: Bioorg Med Chem Lett PMID: 39793629
Prostaglandin E(2) receptor type 4 (EP4) agonists have been shown to be effective in treating experimental ulcerative colitis (UC) in animals and in human clinical trials, but their development has been impeded by unacceptable systemic side effects. In this study, a series of methylene phosphate prodrugs of a highly potent …
Point-of-Care Ultrasound in Gastroenterology and Hepatology
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 39793722
Point-of-care ultrasound (POCUS) is changing the practice of nearly all specialties and is increasingly being incorporated as a bedside tool by more gastroenterologists and hepatologists. POCUS is most often used to answer focused diagnostic questions, supplement the traditional physical examination, and guide performance of invasive bedside procedures. This review describes …
[Progress in the study of the surgical management of Crohn disease based on the mesenteric concept]
Publication Year: 2025 Source: Zhonghua Wai Ke Za Zhi PMID: 39794144
In recent years, with the deepening of mesentery research, it is found that its blood vessels, nerves, lymphoid tissue, adipose tissue and other structures play an important role in the occurrence and development of Crohn disease, and the degree of lesion is related with the disease process, surgical difficulty, the …
Typing of feces-derived Candida albicans strains using a novel seven-locus microsatellite panel reveals associations with yeast phenotype in individuals with inflammatory bowel disease
Publication Year: 2025 Source: Pathog Dis PMID: 39794285 DOI: 10.1093/femspd/ftaf001
Inflammatory diseases of the human gastrointestinal tract are affected by the microbes that reside in the mucosal surfaces. Patients with inflammatory bowel diseases (IBD) have altered bacterial and fungal intestinal compositions, including higher levels of fecal Candida yeasts. Ongoing research indicates that genetic and phenotypic diversity of Candida albicans may …
Withdrawal of antitumour necrosis factor in inflammatory bowel disease patients in remission: a randomised placebo-controlled clinical trial of GETECCU
Publication Year: 2025 Source: Gut PMID: 39794921
BACKGROUND AND OBJECTIVES: Primary objectives: to compare the rates of sustained clinical remission at 12 months in patients treated with antitumour necrosis factor (anti-TNF) and immunomodulators who withdraw anti-TNF treatment versus those who maintain it. SECONDARY OBJECTIVES: to evaluate the effect of anti-TNF withdrawal on relapse-free time, endoscopic and radiological …
Is the biogeography of the mucosa-associated microbiota a key factor affecting primary sclerosing cholangitis disease course and treatment?
Publication Year: 2025 Source: Gut PMID: 39794922
No Abstract
A New Strategy in Modulating the Protease-Activated Receptor 2 (Par2) in Autoimmune Diseases
Publication Year: 2025 Source: Int J Mol Sci PMID: 39796264
Autoimmune diseases are complex conditions characterized by immune-mediated tissue damage and chronic inflammation. Protease-activated receptor 2 (Par2) has been implicated in these diseases, exhibiting dual roles that complicate its therapeutic potential. This review examines the perplexing functions of Par2, which promotes inflammation through immune cell activation while facilitating tissue healing …
Chronic Gastrointestinal Disorders and miRNA-Associated Disease: An Up-to-Date
Publication Year: 2025 Source: Int J Mol Sci PMID: 39796266 DOI: 10.3390/ijms26010413
Chronic gastrointestinal disorders such as inflammatory bowel diseases (IBDs) and irritable bowel syndrome (IBS) impose significant health burdens globally. IBDs, encompassing Crohn's disease and ulcerative colitis, are multifactorial disorders characterized by chronic inflammation of the gastrointestinal tract. On the other hand, IBS is one of the principal gastrointestinal tract functional …
Continuous Treatment with Tofacitinib but Not Filgotinib Is Effective in Non-Responders with Active Ulcerative Colitis: A Propensity Score-Matching Analysis
Publication Year: 2025 Source: J Clin Med PMID: 39797304
Background: Few studies have compared the efficacy and safety of Janus kinase (JAK) inhibitors in patients with ulcerative colitis (UC). We compared the real-world effectiveness and safety of tofacitinib (TOF) and filgotinib (FIL) as induction therapy for UC by propensity score-matching analysis. Methods: We enrolled 230 patients with active UC …
Editorial: Leucine-Rich Alpha-2 Glycoprotein Is Associated With Transmural Inflammation Assessed by Intestinal Ultrasound in Patients With Crohn's Disease: Its Potential in Early-Stage Disease-Authors' Reply
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 39797383 DOI: 10.1111/apt.18493
No Abstract
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