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Crohn's disease, irritable bowel syndrome, and chronic fatigue: the importance of communication and symptom management-a case report
Publication Year: 2025 Source: J Med Case Rep PMID: 39789666
BACKGROUND: Crohn's disease and irritable bowel syndrome may both cause abdominal pain and diarrhea. Irritable bowel syndrome not only is an important differential diagnosis for Crohn's disease but also occurs in one out of three patients with Crohn's disease in remission in parallel. If not adequately diagnosed and treated, additional …
The efficacy and feasibility of lifestyle interventions on modifiable cardiovascular disease risk factors among people with inflammatory bowel disease
Publication Year: 2025 Source: Proc Nutr Soc PMID: 39789973 DOI: 10.1017/S0029665124007596
This review aims to highlight the relative importance of cardiovascular disease (CVD) lifestyle-associated risk factors among individuals with inflammatory bowel disease (IBD) and examine the effectiveness of lifestyle interventions to improve these CVD risk factors. Adults with IBD are at higher risk of CVD due to systemic and gut inflammation. …
Identification of Biomarkers Related to Liquid-Liquid Phase Separation for Ulcerative Colitis Based on Single-Cell and Bulk RNA Transcriptome Sequencing Data
Publication Year: 2025 Source: Endocr Metab Immune Disord Drug Targets PMID: 39791167
BACKGROUND: Liquid-Liquid Phase Separation (LLPS) is a process involved in the formation of established organelles and various condensates that lack membranes; however, the relationship between LLPS and Ulcerative Colitis (UC) remains unclear. AIMS: This study aimed to comprehensively clarify the correlation between ulcerative colitis (UC) and liquid-liquid phase separation (LLPS). …
Determining the Accuracy and Interobserver Agreement of 4 Ultrasound Scores in Crohn's Disease Assessment: Correlations With Endoscopy
Publication Year: 2025 Source: Clin Transl Gastroenterol PMID: 39791555
INTRODUCTION: Gastrointestinal ultrasound (GIUS) is recommended for monitoring Crohn's disease (CD). GIUS scores are used to quantify CD activity. Among them, International Bowel Ultrasound Segmental Activity Score (IBUS-SAS), Bowel Ultrasound Score (BUSS), Simple Ultrasound Score, and Simple Ultrasound Score for Crohn's Disease are most commonly used. The aim of this …
Vidofludimus Calcium in Patients With Moderate-to-Severe Ulcerative Colitis: A Randomized, Placebo-Controlled, Phase 2 Trial
Publication Year: 2025 Source: Clin Transl Gastroenterol PMID: 39791563
INTRODUCTION: Vidofludimus calcium (VidoCa) is a dihydroorotate dehydrogenase inhibitor that demonstrated efficacy in immune-related diseases. This study assessed the safety and efficacy of VidoCa in patients with active ulcerative colitis (UC). METHODS: This placebo-controlled, phase 2 trial randomized adults with moderate-to-severe UC to receive once-daily VidoCa (10, 30, or 45 …
Joint analysis of genome-wide cross-trait and multi-omics reveals molecular mechanisms of inflammatory bowel disease and nominates its novel therapeutic genes
Publication Year: 2025 Source: FASEB J PMID: 39792054 DOI: 10.1096/fj.202402489R
Inflammatory bowel disease (IBD) with the two predominant endophenotypes-Crohn's disease (CD) and ulcerative colitis (UC)-represents a group of chronic gastrointestinal inflammatory conditions. Since most genetic associations with IBD are often limited to independent subtypes, we reported a genome-wide association study (GWAS) cross-trait analysis combined with CD and UC to enhance …
[Treatment of severe flares in Crohn's disease and ulcerative colitis]
Publication Year: 2025 Source: Inn Med (Heidelb) PMID: 39792265 DOI: 10.1007/s00108-024-01825-w
BACKGROUND: In chronic inflammatory bowel diseases (IBD), severe flares are characterized by intense inflammatory activity and a high disease burden for patients. Treatment addresses both short-term goals (e.g., symptom reduction, prevention of complications) and long-term goals (sustained clinical steroid-free remission and healing of inflammatory lesions, known as "mucosal healing"). OBJECTIVE …
Familial Mediterranean fever with sigmoid colon stricture
Publication Year: 2025 Source: Clin J Gastroenterol PMID: 39792323
We describe a case of familial Mediterranean fever (FMF) with sigmoid colon stricture. The patient, a woman in her 30 s, had a 12-year history of ileocolitis-type Crohn's disease. The colonoscope could not pass because of the sigmoid colon stricture, and the patient was referred to our hospital with complaints …
Mechanisms underlying changes in intestinal permeability during pregnancy and their implications for maternal and infant health
Publication Year: 2025 Source: J Reprod Immunol PMID: 39793281
Proper regulation of intestinal permeability is essential for maintaining the integrity of the intestinal mucosal barrier. An abnormal increase in permeability can significantly contribute to the onset and progression of various diseases, including autoimmune disorders, metabolic conditions, allergies, and inflammatory bowel diseases. The potential connection between intestinal permeability and maternal …
Tamuzimod in patients with moderately-to-severely active ulcerative colitis: a multicentre, double-blind, randomised, placebo-controlled, phase 2 induction trial
Publication Year: 2025 Source: Lancet Gastroenterol Hepatol PMID: 39793589
BACKGROUND: Tamuzimod (VTX002) is a selective sphingosine 1-phosphate receptor 1 modulator in development for ulcerative colitis. We aimed to assess the safety and efficacy of tamuzimod in patients with moderately-to-severely active ulcerative colitis. METHODS: This double-blind, randomised, placebo-controlled, phase 2 induction trial was conducted at 122 centres across 15 countries …
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