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A Nomogram Based on Laboratory Data, Inflammatory Bowel Disease Questionnaire and CT Enterography for Activity Evaluation in Crohn's Disease
Publication Year: 2025 Source: J Inflamm Res PMID: 39802507
BACKGROUND: Accurately assessing the activity of Crohn's disease (CD) is crucial for determining prognosis and guiding treatment strategies for CD patients. OBJECTIVE: This study aimed to develop and validate a nomogram for assessing CD activity. METHODS: The semi-automatic segmentation method and PyRadiomics software were employed to segment and extract radiomics …
Effectiveness and safety of oral vancomycin for the treatment of inflammatory bowel disease associated with primary sclerosing cholangitis: a systematic review and pooled analysis
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 39802627 DOI: 10.1177/17562848241312766
BACKGROUND: Inflammatory bowel disease (IBD) occurs in up to 70%-80% of patients with primary sclerosing cholangitis (PSC). Oral vancomycin therapy (OVT) has been reported to be effective in the treatment of IBD associated with PSC (IBD-PSC). OBJECTIVES: To examine the effectiveness and safety of OVT in the treatment of IBD-PSC …
Pathobiont-triggered induction of epithelial IDO1 drives regional susceptibility to Inflammatory Bowel Disease
Publication Year: 2025 Source: bioRxiv PMID: 39803424
The structure and function of the mammalian gut vary by region, yet why inflammatory diseases manifest in specific regions and not others remains unclear. We use a TNF-overexpressing Crohn's disease (CD) model (Tnf(DeltaARE/+)), which typically presents in the terminal ileum (TI), to investigate how environmental factors interact with the host's …
Correlation between IL-17 and inflammatory bowel disease
Publication Year: 2025 Source: Egypt J Immunol PMID: 39803916 DOI: 10.55133/eji.320106
Inflammatory bowel disease (IBD) is a protracted, persistent gastrointestinal disease that is distinguished by recurring, persistent inflammation of the digestive tract. IBD, including Crohn's disease and ulcerative colitis, is characterized by persistent inflammation due to immune dysregulation. Interleukin -17 (IL-17) contributes significantly to the pathophysiology of IBD, as highlighted in …
The Clinical utility of Interleukin-17A rs2275913 polymorphism with colorectal cancer in Egyptian patients
Publication Year: 2025 Source: Egypt J Immunol PMID: 39804134 DOI: 10.55133/eji.320109
The worldwide incidence of colorectal cancer (CRC) is roughly two million new instances each year throughout the world, according to the World Health Organization 2022. CRC is the third most prevalent disease and the second most common cancer in terms of fatality. People diagnosed with colorectal cancer in the early …
Modification of Ganoderma lucidum spore shells into probiotic carriers: selective loading and colonic delivery of Lacticaseibacillus rhamnosus and effective therapy of inflammatory bowel disease
Publication Year: 2025 Source: Food Funct PMID: 39804290 DOI: 10.1039/d4fo04523h
Inflammatory bowel disease (IBD) is a chronic inflammation with a high incidence rate. Many probiotics, including Lacticaseibacillus rhamnosus (L. rhamnosus), have shown promise in IBD treatment. The therapeutic effects of most probiotics are greatly decided by the available live cells in the disease lesion, which is compromised as they pass …
Risankizumab efficacy and safety based on prior inadequate response or intolerance to advanced therapy: post hoc analysis of the INSPIRE and COMMAND phase 3 studies
Publication Year: 2025 Source: J Crohns Colitis PMID: 39804294
BACKGROUND AND AIMS: Treating ulcerative colitis (UC) in patients with prior advanced therapy (AT) exposure may be challenging. We report the efficacy and safety of risankizumab, a monoclonal interleukin 23p19 antibody, in patients with UC and prior inadequate response or intolerance to AT (AT-IR). METHODS: In the 12-week phase 3 …
Updated Review for Guidelines for Cervical Cancer Screening in Immunosuppressed Women Without HIV Infection
Publication Year: 2025 Source: J Low Genit Tract Dis PMID: 39804372 DOI: 10.1097/LGT.0000000000000866
OBJECTIVE: The purpose of this review was to examine new evidence since the authors' 2019 guidelines for cervical cancer (CC) screening in non-HIV immunocompromised persons and to provide updated recommendations based on literature review and expert opinion. In addition, human papillomavirus (HPV) vaccine efficacy in these populations was reviewed. METHODS: …
Effect of Fecal Microbiota Transplant on Antibiotic Resistance Genes Among Patients with Chronic Pouchitis
Publication Year: 2025 Source: Dig Dis Sci PMID: 39804518
BACKGROUND: Pouchitis is common among patients with ulcerative colitis (UC) who have had colectomy with ileal pouch-anal anastomosis. Antibiotics are first-line therapy for pouch inflammation, increasing the potential for gut colonization with multi-drug resistant organisms (MDRO). Fecal microbial transplant (FMT) is being studied in the treatment of pouchitis and in …
Improvement in serum eosinophilia is observed in clinical responders to ustekinumab but not adalimumab in inflammatory bowel disease
Publication Year: 2025 Source: J Crohns Colitis PMID: 39804709 DOI: 10.1093/ecco-jcc/jjaf006
INTRODUCTION: In inflammatory bowel disease (IBD), the number of eosinophils increases in the lamina propria of the intestinal tract, but their specific patho-mechanistic role remains unclear. Elevated blood eosinophil counts in active IBD suggest their potential as biomarkers for predicting response to biological therapies. This study evaluates blood eosinophil count …
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