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Childhood-onset inflammatory bowel disease and chronic non-bacterial osteomyelitis: a Swedish nationwide cohort study 2002-2022
Publication Year: 2025 Source: J Crohns Colitis PMID: 39804716 DOI: 10.1093/ecco-jcc/jjaf007
BACKGROUND AND AIMS: Nationwide, population-based studies of chronic non-bacterial osteomyelitis (CNO) in patients with childhood-onset inflammatory bowel disease (IBD) are lacking. METHODS: We used nationwide registers to identify all children in Sweden diagnosed with IBD during 2002-2022 and the occurrence of CNO in this IBD cohort and general population non-IBD …
Iron deficiency and fatigue in inflammatory bowel disease: A systematic review
Publication Year: 2025 Source: PLoS One PMID: 39804874 DOI: 10.1371/journal.pone.0304293
BACKGROUND: It is unclear what impact iron deficiency has on fatigue in people with inflammatory bowel disease (IBD). This systematic review examined the evidence of whether iron deficiency, with or without anaemia, was associated with fatigue in IBD. Fatigue is a common symptom in patients with IBD that can be …
Injectable DAT-ALG Hydrogel Mitigates Senescence of Loaded DPMSCs and Boosts Healing of Perianal Fistulas in Crohn's Disease
Publication Year: 2025 Source: ACS Biomater Sci Eng PMID: 39804997
Perianal fistulas (PAFs) are a severe complication of Crohn's disease that significantly impact patient prognosis and quality of life. While stem-cell-based strategies have been widely applied for PAF treatment, their efficacy remains limited. Our study introduces an injectable, temperature-controlled decellularized adipose tissue-alginate hydrogel loaded with dental pulp mesenchymal stem cells …
Diversity and function of regulatory T cells in health and autoimmune diseases
Publication Year: 2025 Source: J Autoimmun PMID: 39805189
Regulatory T cell (Treg) play a pivotal role in immune regulation and maintaining host immune homeostasis. Treg heterogeneity, characterized by diverse gene expression profiles and functional states, is complex in both health and disease. Research reveals that Tregs are not a uniform population but exhibit diversity based on their origin, …
Monitoring for 5-aminosalicylate nephrotoxicity in adults with inflammatory bowel disease: prognostic model development and validation using data from the Clinical Practice Research Datalink
Publication Year: 2025 Source: BMJ Open Gastroenterol PMID: 39863289
OBJECTIVE: To develop and validate a prognostic model for risk-stratified monitoring of 5-aminosalicylate nephrotoxicity. METHODS: This UK retrospective cohort study used data from the Clinical Practice Research Datalink Aurum and Gold for model development and validation respectively. It included adults newly diagnosed with inflammatory bowel disease and established on 5-aminosalicylic …
[Research progress of very early onset and monogenic inflammatory bowel disease and pathological diagnosis]
Publication Year: 2025 Source: Zhonghua Bing Li Xue Za Zhi PMID: 39863544
No Abstract
SAA3 deficiency exacerbates intestinal fibrosis in DSS-induced IBD mouse model
Publication Year: 2025 Source: Cell Death Discov PMID: 39863585 DOI: 10.1038/s41420-025-02299-x
Intestinal fibrosis, as a late-stage complication of inflammatory bowel disease (IBD), leads to bowel obstruction and requires surgical intervention, significantly lowering the quality of life of affected patients. SAA3, a highly conserved member of the serum amyloid A (SAA) apolipoprotein family in mice, is synthesized primarily as an acute phase …
Hereditary colorectal cancer syndromes and inflammatory bowel disease: results from a registry-based study
Publication Year: 2025 Source: Int J Colorectal Dis PMID: 39863767 DOI: 10.1007/s00384-025-04808-x
PURPOSE: In this study, we investigated the progression of high-grade dysplasia (HGD)/CRC in patients with hereditary colorectal cancer syndromes (HCSS) and concomitant inflammatory bowel diseases (IBDs). METHODS: We described the natural history of a series of patients with confirmed diagnosis of hereditary colorectal cancer syndromes (HCCSs) and concomitant IBDs who …
Genetically engineered bacteria expressing IL-34 alleviate DSS-induced experimental colitis by promoting tight junction protein expression in intestinal mucosal epithelial cells
Publication Year: 2025 Source: Mol Immunol PMID: 39864284
BACKGROUND: The intestinal mucosa of ulcerative colitis patients expresses high levels of interleukin 34, and mice lacking IL-34 have more severe DSS-induced experimental colitis. There are no studies on the effects of directly upregulating intestinal IL-34 on experimental colitis in mice. METHODS: The bacteria EcN/CSF-1 and EcN/IL-34, which express CSF-1 …
Regulation of NLRP3/TRIM family signaling in gut inflammation and colorectal cancer
Publication Year: 2025 Source: Biochim Biophys Acta Rev Cancer PMID: 39864469 DOI: 10.1016/j.bbcan.2025.189271
CRC (Colorectal cancer) ranks among the most prevalent tumors in humans and remains a leading cause of cancer-related mortality worldwide. Numerous studies have highlighted the connection between inflammasome over-activation and the initiation and progression of CRC. The activation of the NLRP3 (NOD-like receptor family, pyrin domain containing 3) inflammasome is …
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