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Long-term outcomes of 'temporary' defunctioning in patients with severe perianal Crohn's disease
Publication Year: 2025 Source: Colorectal Dis PMID: 39887905
AIM: This study aimed to analyse long-term outcomes in patients undergoing temporary faecal diversion for therapy-refractory Crohn's perianal fistulas. METHODS: In this retrospective study, Crohn's patients who underwent defunctioning for perianal disease between 2012 and 2022 were included. The primary endpoints were successful ostomy reversal and proctectomy/proctocolectomy rates. Secondary endpoints …
Ustekinumab is safe and effective in pediatric patients with Crohn's disease
Publication Year: 2025 Source: J Pediatr Gastroenterol Nutr PMID: 39888083
OBJECTIVES: Real-world data on ustekinumab for the treatment of pediatric Crohn's disease (CD) are limited. This study sought to evaluate the effectiveness, long-term durability, and safety of ustekinumab in the treatment of children with CD. METHODS: A retrospective longitudinal cohort study of children with CD treated with ustekinumab from two …
Chronic Use of Proton Pump Inhibitors Is Associated With Reduced 30-Day Mortality From Acute Pancreatitis
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 39888102
Proton pump inhibitors (PPIs) decrease pancreatic exocrine secretions. There has been interest in the impact of their short-term in-hospital administration on acute pancreatitis (AP) outcomes. It is unknown whether long-term use affects AP outcomes. We investigated the association between chronic PPI use and short-term AP outcomes. We included all (2308) …
Elevated SPARC Disrupts the Intestinal Barrier Integrity in Crohn's Disease by Interacting with OTUD4 and Activating the MYD88/NF-κB Pathway
Publication Year: 2025 Source: Adv Sci (Weinh) PMID: 39888301
Disruption of the intestinal epithelial barrier results in increased permeability and is a key factor in the onset and progression of Crohn's disease (CD). The protein SPARC is primarily involved in cell interaction and migration, but its specific role in the intestinal epithelial barrier remains unclear. This study demonstrates that …
Lysophosphatidylcholine-induced aberrant adipogenesis in mesenchymal stem cells and impaired antibacterial function in adipocytes of creeping fat
Publication Year: 2025 Source: J Crohns Colitis PMID: 39888411
BACKGROUND AND AIM: Creeping fat (CF) in Crohn's disease (CD) is characterized by hyperplastic mesenteric adipose tissue (MAT) encasing fibrotic intestinal segments. Creeping fat exhibits disruptions in microbiota and lipid metabolism, particularly in lysophosphatidylcholine (LPC). This study aims to elucidate the impact of LPC on adipogenic differentiation of mesenchymal stem …
HIV Infection Is Associated With a Less Aggressive Phenotype of Inflammatory Bowel Disease: A Multicenter Study of the ENEIDA Registry
Publication Year: 2025 Source: Am J Gastroenterol PMID: 39888687 DOI: 10.14309/ajg.0000000000002965
INTRODUCTION: The coexistence of HIV infection and inflammatory bowel disease (IBD) is uncommon. Data on the impact of HIV on IBD course and its management are scarce. The aim of this study was to describe the IBD phenotype, therapeutic requirements, and prevalence of opportunistic infections (OIs) in IBD patients with …
Combination of white-light imaging-based and narrow-band imaging-based artificial intelligence models during colonoscopy in patients with ulcerative colitis
Publication Year: 2025 Source: J Crohns Colitis PMID: 39888722
BACKGROUND AND AIMS: The long-term treat-to-target (T2T) approach in ulcerative colitis (UC) aims for endoscopic remission, but variability among endoscopists and a lack of precision in relapse prediction both limit its clinical usefulness. A recently reported white-light imaging (WLI) artificial intelligence (AI) model helps standardize diagnosis, although challenges remain. Therefore, …
Management of disease-related abdominal abscesses in Crohn's disease
Publication Year: 2025 Source: Expert Rev Gastroenterol Hepatol PMID: 39889271
INTRODUCTION: Crohn's disease (CD)-related abdominal abscesses require tailored management strategies taking into consideration the variability in abscess size, location, and underlying CD activity. AREAS COVERED: This review discusses current approaches to CD-related abscesses. Literature review was performed through the PubMed and Medline databases to identify studies pertinent to the wide-ranging …
From Ulcerative Colitis to Metastatic Colorectal Cancer: The Neutrophil Contribution
Publication Year: 2025 Source: Am J Pathol PMID: 39889826
Ulcerative colitis (UC) is an inflammatory colon and rectum disease affecting approximately 5 million people worldwide. There is no cure for UC, and approximately 8% of patients with UC develop colorectal cancer (CRC) by gradual acquisition of mutations driving the formation of adenomas and their progression to adenocarcinomas and metastatic …
Long-term safety and sustained efficacy of bimekizumab in patients with ankylosing spondylitis (radiographic axial spondyloarthritis): 5-year results from BE AGILE (phase 2b) and its open-label extension
Publication Year: 2025 Source: RMD Open PMID: 39890205
OBJECTIVE: Assess long-term safety, tolerability and efficacy of bimekizumab in ankylosing spondylitis (radiographic axial spondyloarthritis (r-axSpA)). METHODS: Patients with active r-axSpA completing the dose-ranging 48-week randomised controlled trial could enrol in the open-label extension, where patients received bimekizumab 160 mg every 4 weeks. Safety (exposure-adjusted incidence rates/100 patient-years (EAIRs)) and …
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