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What is the future potential of microbially degradable systems in oral drug delivery to the colon?
Publication Year: 2025 Source: Expert Opin Drug Deliv PMID: 39886915
No Abstract
Progress in the investigation of the Firmicutes/Bacteroidetes ratio as a potential pathogenic factor in ulcerative colitis
Publication Year: 2025 Source: J Med Microbiol PMID: 39886918 DOI: 10.1099/jmm.0.001966
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) that presents significant challenges in terms of treatment owing to a pronounced likelihood of recurrence and an elevated risk of cancer development, thereby imposing substantial risks on affected individuals. The gut microbiota of Firmicutes and Bacteroidetes (F/B) can affect diseases …
Janus kinase inhibitors in the management of acute severe ulcerative colitis: a comprehensive review
Publication Year: 2025 Source: J Crohns Colitis PMID: 39886994
BACKGROUND: One-third of patients with acute severe ulcerative colitis (ASUC) are steroid-refractory. Cyclosporine and infliximab are currently the mainstays of salvage therapy. Janus kinase inhibitors (JAKi) could play a role in the treatment of ASUC. AIM: To review the evidence on JAKi in the management of ASUC. METHODS: We performed …
A pro-inflammatory diet is associated with growth and virulence of Escherichia coli in pediatric Crohn's disease
Publication Year: 2025 Source: J Crohns Colitis PMID: 39887086
BACKGROUND AND AIMS: Epidemiological studies have suggested an association between the inflammatory potential of dietary patterns and Crohn's disease (CD). However, the relationships of these inflammatory dietary determinants with the microbiome remain largely unknown. In this cross-sectional study, we evaluate the association between the inflammatory potential of habitual diet, as …
When Patients With IBD Require an Ostomy: Evidence-Based Answers to 10 Common Clinical Questions in IBD Surgery
Publication Year: 2025 Source: Am J Gastroenterol PMID: 39887123 DOI: 10.14309/ajg.0000000000002914
No Abstract
The ability of C-reactive protein-albumin ratio to predict disease activity in ulcerative colitis
Publication Year: 2025 Source: Biomark Med PMID: 39887140
AIM: Ulcerative colitis (UC) is an incurable disease represented by relapse and remission. Noninvasive biomarkers are required to predict disease activation. This study aimed to identify noninvasive biomarkers, such as the c-reactive protein-albumin (CRP/ALB) ratio, platelet-lymphocyte ratio (PLR), and neutrophil-lymphocyte ratio (NLR), that might forecast disease activation in UC. METHODS: …
Resting-State Functional Connectivity of the Cerebellum Differs Between Persons With Inflammatory Bowel Disease and Healthy Controls in Relation to Executive Function
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39887158
No Abstract
'Psoriasis Punctata': An Under-Recognised Clinical Phenotype of TNF-Alpha Inhibitor-Induced Psoriasis
Publication Year: 2025 Source: Australas J Dermatol PMID: 39887345
No Abstract
Redox-Induced Stabilization of AMBRA1 by USP7 Promotes Intestinal Oxidative Stress and Colitis Through Antagonizing DUB3-Mediated NRF2 Deubiquitination
Publication Year: 2025 Source: Adv Sci (Weinh) PMID: 39887666 DOI: 10.1002/advs.202411320
Inflammatory bowel disease (IBD) is associated with oxidative stress and redox signaling disruption. It is recently reported that proautophagic autophagy/beclin-1 regulator 1 (AMBRA1) is a positive modulator of the NF-kappaB pathway that promotes intestinal inflammation. However, its effect on intestinal redox state and whether AMBRA1 is regulated by oxidative stress …
Combining TNF-α Inhibitors with IL-4, IL-17, IL-23, or JAK Inhibitors in Patients with Multiple, Severe Dermatologic Conditions and/or Gastrointestinal or Rheumatologic Disease
Publication Year: 2025 Source: J Cutan Med Surg PMID: 39887685
No Abstract
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