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HDAC inhibitors and IBD: Charting new approaches in disease management
Publication Year: 2025 Source: Int Immunopharmacol PMID: 39892171 DOI: 10.1016/j.intimp.2025.114193
Inflammatory bowel disease (IBD) represents a group of chronic inflammatory disorders of the gastrointestinal tract. Despite substantial advances in our understanding of IBD pathogenesis, the currently available therapeutic options remain limited in their efficacy and often come with significant side effects. Therefore, there is an urgent need to explore novel …
Antidepressants for inflammatory bowel disease? Multimodal effects of amitriptyline in murine colitis
Publication Year: 2025 Source: J Pharmacol Exp Ther PMID: 39892208
No Abstract
Safety and Clinical Effectiveness of GLP1 Receptor Agonists in Inflammatory Bowel Disease Patients
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 39892632
No Abstract
Macrophage-targeting nano-formulated bicalutamide alleviates colitis by inducing MAP3K1-mediated degradation of NLRP3
Publication Year: 2025 Source: J Control Release PMID: 39892647 DOI: 10.1016/j.jconrel.2025.01.076
The excessive activation of the NOD-like receptor thermal protein domain associated protein 3 (NLRP3) in macrophages has been recognized as a critical factor in the exacerbation of severe inflammatory bowel disease (IBD). Consequently, the modulation of macrophage NLRP3 activity may serve as an effective strategy for mitigating IBD. Our study …
Tumor Cellularity Assessment Using Artificial Intelligence Trained on Immunohistochemistry-Restained Slides Improves Selection of Lung Adenocarcinoma Samples for Molecular Testing
Publication Year: 2025 Source: Am J Pathol PMID: 39892778
Tumor cellularity (TC) in lung adenocarcinoma slides submitted for molecular testing is important in identifying actionable mutations, but lack of best practice guidelines results in high interobserver variability in TC assessments. An artificial intelligence (AI)-based pipeline developed to assess TC in hematoxylin and eosin (H&E) whole slide images (WSIs) and …
Autophagy inhibitor 3-methyladenine mitigates the severity of colitis in aged mice by inhibiting autophagy
Publication Year: 2025 Source: Exp Gerontol PMID: 39892795
BACKGROUND: The elderly ulcerative colitis (UC) patients pose unique challenges due to their comorbidities, diminished functional capacity, and heightened risk of treatment-related complications. Thus, finding a safe and effective treatment for this age group is crucial. AIM: This study investigates the role of autophagy in the pathogenesis of UC in …
The protective effect of amitriptyline on experimental colitis through inhibiting TLR-4/MD-2 signaling pathway
Publication Year: 2025 Source: J Pharmacol Exp Ther PMID: 39892990 DOI: 10.1124/jpet.124.002207
Amitriptyline, a pleiotropic tricyclic antidepressant, possesses antioxidant and anti-inflammatory properties. Despite its diverse benefits, the specific effects of amitriptyline on inflammatory bowel disease (IBD) are not yet well defined. To explore this, we used a dextran sulfate sodium (DSS)-induced colitis model to examine the anti-inflammatory effects of amitriptyline and the …
Epidemiology and temporal trends of adult inflammatory bowel disease in Taiwan: Multicenter study from the TSIBD registration
Publication Year: 2025 Source: J Formos Med Assoc PMID: 39893095 DOI: 10.1016/j.jfma.2025.01.018
BACKGROUND: Despite industrialization and advances in healthcare, the prevalence of inflammatory bowel disease (IBD), which encompasses Crohn's disease (CD) and ulcerative colitis (UC), is increasing in Taiwan. Population-based studies can estimate the incidence or prevalence of IBD; however, there is a lack of information regarding the disease phenotype. Therefore, this …
A modified totally stapled KONO-S anastomosis for ileal and ileo-colic Crohn's disease: technical aspects and case series
Publication Year: 2025 Source: Updates Surg PMID: 39893597
Crohn's disease (CD) is a chronic immune-mediated disorder affecting the gastrointestinal tract. While medical therapies have advanced, approximately 80% of CD patients will require surgery due to disease recurrence. A significant debate exists regarding the primary site of post-operative recurrence. This discrepancy in recurrence patterns underscores the complexity of CD …
mRNA expression profile from whole blood revealed a cluster of 25 shared differentially expressed genes inversely related in multiple sclerosis and inflammatory bowel disease
Publication Year: 2025 Source: Mult Scler Relat Disord PMID: 39893753 DOI: 10.1016/j.msard.2025.106301
BACKGROUND: Multiple Sclerosis (MS) and Inflammatory Bowel Disease (IBD) are immune-mediated disorders with a significant concurrence among patients and share considerable genetic variations and environmental factors. This study aimed to identify shared differentially expressed genes (DEGs) between MS and IBD using mRNA expression data analysis to improve understanding of their …
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