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Exploring Immune Cell Infiltration and Small Molecule Compounds for Ulcerative Colitis Treatment
Publication Year: 2024 Source: Genes (Basel) PMID: 39766817 DOI: 10.3390/genes15121548
BACKGROUND/OBJECTIVES: Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) with a relapsing nature and complex etiology. Bioinformatics analysis has been widely applied to investigate various diseases. This study aimed to identify crucial differentially expressed genes (DEGs) and explore potential therapeutic agents for UC. METHODS: The GSE47908 and GSE55306 …
Probiotic Microorganisms in Inflammatory Bowel Diseases: Live Biotherapeutics as Food
Publication Year: 2024 Source: Foods PMID: 39767038 DOI: 10.3390/foods13244097
(1) Background: Inflammatory bowel diseases (IBDs) are characterized by chronic and complex inflammatory processes of the digestive tract that evolve with frequent relapses and manifest at any age; they predominantly affect young individuals. Diet plays a direct role in maintaining the gut mucosal integrity and immune function. Regarding the diet, …
Analysis of the Incidence of Ocular Extraintestinal Manifestations in Inflammatory Bowel Disease Patients: A Systematic Review
Publication Year: 2024 Source: Diagnostics (Basel) PMID: 39767176 DOI: 10.3390/diagnostics14242815
Background: Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, primarily affects the gastrointestinal tract. Additionally, extraintestinal manifestations may occur in the liver, musculoskeletal system and eyes. Its etiology remains unknown, and further research is required in order to develop pharmacological drugs which achieve complete remission of the …
Enhancing Inner Area Revaluation Through Optional Control Programmes for Infectious Bovine Rhinotracheitis and Ruminant Paratuberculosis Potentially Linked to Crohn's Disease in Humans
Publication Year: 2024 Source: Int J Environ Res Public Health PMID: 39767436
No Abstract
Fecal Nervonic Acid as a Biomarker for Diagnosing and Monitoring Inflammatory Bowel Disease
Publication Year: 2024 Source: Biomedicines PMID: 39767671 DOI: 10.3390/biomedicines12122764
BACKGROUND/OBJECTIVES: Inflammatory bowel disease (IBD) is a chronic immune-mediated pathology associated with the dysregulation of lipid metabolism. The administration of nervonic acid, a very long-chain fatty acid, has been shown to improve colonic inflammation in a mouse model of colitis. Our study aimed to quantify fecal levels of nervonic acid, …
Ocular Manifestations of IBD: Pathophysiology, Epidemiology, and Iatrogenic Associations of Emerging Treatment Strategies
Publication Year: 2024 Source: Biomedicines PMID: 39767762 DOI: 10.3390/biomedicines12122856
Inflammatory bowel disease (IBD) is a complex, multisystemic disease and is associated with ocular pathology in 4-12% of patients. In general, ocular disease affects Crohn's patients more frequently than those with ulcerative colitis. Episcleritis and uveitis are the most common presentations, with episcleritis often correlating with IBD flares, whereas uveitis …
Administration of Adipose-Derived Stem Cells After the Onset of the Disease Does Not Lower the Levels of Inflammatory Cytokines IL1 and IL6 in a Rat Model of Necrotizing Enterocolitis
Publication Year: 2024 Source: Biomedicines PMID: 39767803
No Abstract
Bile Acids in Inflammatory Bowel Disease: From Pathophysiology to Treatment
Publication Year: 2024 Source: Biomedicines PMID: 39767816 DOI: 10.3390/biomedicines12122910
Inflammatory bowel disease (IBD) is a chronic condition that affects about 7 million people worldwide, and new therapies are needed. Understanding the complex roles that bile acids (BAs) play in IBD may lead to the development of novel IBD treatments independent of direct immunosuppression. This review discusses the latest discoveries …
Patient-Reported Outcomes Measurement Information System as a Clinical Tool for Capturing the Patient Perspective in Pediatric Inflammatory Bowel Disease: A Narrative Review
Publication Year: 2024 Source: Children (Basel) PMID: 39767921 DOI: 10.3390/children11121492
Inflammatory bowel disease (IBD) is an immune-mediated chronic disease with a significant impact on quality of life. In pediatric patients, diagnosing and managing IBD is particularly challenging, and IBD often presents as a more severe and progressive disease. Patient-reported outcomes (PROs) are measures of treatment and disease management outcomes reported …
Assessment of Extracellular Particles Directly in Diluted Plasma and Blood by Interferometric Light Microscopy. A Study of 613 Human and 163 Canine Samples
Publication Year: 2024 Source: Cells PMID: 39768146 DOI: 10.3390/cells13242054
Extracellular nanoparticles (EPs) are a subject of increasing interest for their biological role as mediators in cell-cell communication; however, their harvesting and assessment from bodily fluids are challenging, as processing can significantly affect samples. With the aim of minimizing processing artifacts, we assessed the number density (n) and hydrodynamic diameter …
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