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Orally delivered biodegradable targeted inflammation resolving pectin-coated nanoparticles induce anastomotic healing post intestinal surgery
Publication Year: 2024 Source: Sci Rep PMID: 39587209 DOI: 10.1038/s41598-024-80886-1
Targeted perioperative therapeutics supporting anastomotic healing during colitis are an urgent medical need. This study aimed to develop and evaluate a novel nanoparticle (NP)-based drug delivery system for improving anastomotic healing in Inflammatory bowel disease (IBD) patients following surgery. We developed pectin-coated polymeric NPs encapsulating the inflammation-resolving peptide Ac2-26. These …
Effect of past extensive ulcers on fecal calprotectin in ulcerative colitis
Publication Year: 2024 Source: BMC Gastroenterol PMID: 39587487
No Abstract
Comparison of Crohn's disease-associated adherent-invasive Escherichia coli (AIEC) from France and Hong Kong: results from the Pacific study
Publication Year: 2024 Source: Gut Microbes PMID: 39587720
No Abstract
[Clinical characteristics and nutritional status of children with Crohn's disease and risk factors for malnutrition]
Publication Year: 2024 Source: Zhongguo Dang Dai Er Ke Za Zhi PMID: 39587749
No Abstract
The Role of the TRPV4 Channel in Intestinal Physiology and Pathology
Publication Year: 2024 Source: J Inflamm Res PMID: 39588136 DOI: 10.2147/JIR.S483350
The transient receptor potential vanilloid 4 channel (TRPV4) is an important member of the TRP superfamily of cation channels. The channel can be activated by different physical and chemical stimuli, such as heat, osmotic, and mechanical stress. It regulates the release of nociceptive peptides (substance P and calcitonin gene-related peptide), …
Advances in research on the role of high carbohydrate diet in the process of inflammatory bowel disease (IBD)
Publication Year: 2024 Source: Front Immunol PMID: 39588368 DOI: 10.3389/fimmu.2024.1478374
Inflammatory bowel disease (IBD) is a chronic, systemic gastrointestinal disorder characterized by episodic inflammation that requires life-long management. Although the etiology of IBD is not fully understood, it is hypothesized to involve a multifaceted interplay among genetic susceptibility, the host immune response, and environmental factors. Previous studies have largely concluded …
Persistence, Effectiveness, and Safety of Upadacitinib in Crohn's Disease and Ulcerative Colitis in Real Life: Results From a Spanish Nationwide Study (Ureal Study)
Publication Year: 2024 Source: Am J Gastroenterol PMID: 39588977 DOI: 10.14309/ajg.0000000000003243
INTRODUCTION: Real-world data on the effectiveness of upadacitinib for inflammatory bowel disease (IBD) are limited. To assess upadacitinib persistence, effectiveness, and safety in a real-world scenario. METHODS: Retrospective multicenter study of patients with IBD who received upadacitinib before 31st December 2022 and at least 12 weeks before the recruitment date. …
Small-Molecule Neutrophil Modulator ADS051 is Safe and Well-Tolerated in a Phase 1 Single Ascending Dose Study
Publication Year: 2024 Source: Am J Gastroenterol PMID: 39588987
No Abstract
Recent Advances in Gut Microbiome Modulation: Effect of Probiotics, Prebiotics, Synbiotics, and Postbiotics in Inflammatory Bowel Disease Prevention and Treatment
Publication Year: 2024 Source: Curr Microbiol PMID: 39589525 DOI: 10.1007/s00284-024-03997-y
The human gastrointestinal tract contains trillions of microbes that affect the body. Dysbiosis in the composition of gut microbiota is one of the leading causes of chronic inflammatory diseases such as inflammatory bowel disease (IBD). IBD is a global public health challenge and millions of people in the world are …
The role of the mucosal barrier system in maintaining gut symbiosis to prevent intestinal inflammation
Publication Year: 2024 Source: Semin Immunopathol PMID: 39589551
No Abstract
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