Research Articles Library
Literature Analysis Tools
Advanced Search
Filter by PMID, year, source, DOI and other criteria
Literature Analysis
Analyze research trends and hotspots
Batch Export
Export search results to Excel/PDF
Concurrent interstitial pneumonia and acute hepatitis induced by mesalazine
Publication Year: 2025 Source: BMJ Case Rep PMID: 40592593
Ulcerative colitis includes gastrointestinal and, in some cases, extraintestinal symptoms, potentially affecting any organ. Diagnosing such extraintestinal involvement can be challenging, especially when considering alternative aetiologies, including drug-induced toxicity. We report the case of an octogenarian male recently diagnosed with ulcerative colitis and undergoing treatment with mesalazine who was diagnosed …
Fecal Microbiota Transplantation for Immune Regulation: Improving Ulcerative Colitis and Enhancing Cancer Immunotherapy
Publication Year: 2025 Source: Int Immunol PMID: 40592776
The gut microbiota plays an integral role in maintaining health and regulating various host functions, including immune responses. Fecal microbiota transplantation (FMT) has emerged as a promising therapeutic approach to restore gut microbial balance. Although widely recognized for its efficacy in treating ulcerative colitis (UC), FMT is now being investigated …
Predictive model of ulcerative colitis syndrome with ensemble learning and interpretability methods
Publication Year: 2025 Source: Sci Rep PMID: 40593010
In recent years, the prevalence of chronic diseases such as Ulcerative Colitis (UC) has increased, bringing a heavy burden to healthcare systems. Traditional Chinese Medicine (TCM) stands out for its cost-effective and efficient treatment modalities, providing unique advantages in healthcare. But syndrome differentiation of UC presents a longstanding challenge in …
Elevated nitric oxide during colitis restrains GM-CSF production in ILC3 cells via suppressing an AhR-Cyp4f13-NF-κB axis
Publication Year: 2025 Source: Nat Commun PMID: 40593752 DOI: 10.1038/s41467-025-60969-x
Inflammatory bowel disease (IBD) presents a significant clinical challenge, yet the way bioactive gases are implicated remains elusive. We detect elevated colonic Nos2 levels in both IBD patients and mice undergoing diverse colitis. Additionally, Nos2 deficiency significantly aggravates anti-CD40-induced colitis, along with an increase in GM-CSF production by ILC3s. We …
Integrated transcriptomic and proteomic profiling of colonic tissue in interleukin-10-deficient mice
Publication Year: 2025 Source: Sci Data PMID: 40593797 DOI: 10.1038/s41597-025-05212-4
Interleukin (IL)-10, a prominent anti-inflammatory cytokine predominantly secreted by various immune cells, plays a crucial role in the pathophysiological mechanisms of inflammatory bowel disease (IBD). Mice deficient in IL-10 (IL-10(-/-)) progressively develop features of idiopathic enterocolitis as they mature. To advance our understanding of the molecular mechanisms underpinning chronic enterocolitis …
The effects of candidate probiotic strains on the gut environment in dextran sulfate sodium-induced colitis mouse
Publication Year: 2025 Source: Sci Rep PMID: 40593990 DOI: 10.1038/s41598-025-03860-5
Inflammatory bowel disease (IBD) is a chronic condition characterized by intestinal inflammation and dysbiosis, with limited treatment options and significant challenges in long-term management. This study investigated the therapeutic potential of novel strains belonging to Bifidobacterium longum and Limosilactobacillus species, in a dextran sodium sulfate (DSS)-induced mouse model of colitis. …
Comparison of endoscopic healing and durability between combination therapy with infliximab and azathioprine versus infliximab monotherapy in pediatric Crohn's disease
Publication Year: 2025 Source: Sci Rep PMID: 40594430
This retrospective observational study evaluated the effectiveness of endoscopic healing (EH) and the durability of infliximab (IFX) in combination with azathioprine (AZA) versus IFX monotherapy in pediatric patients with Crohn's disease (CD). EH was assessed after 1 year of treatment, whereas IFX durability and associated risk factors were evaluated over …
Extra intestinal manifestations may increase the risk of synchronous and metachronous development of other extraintestinal manifestations in patients with Crohn's disease
Publication Year: 2025 Source: Sci Rep PMID: 40594471
Although Crohn's disease (CD) affects the intestines, it is known to be a systemic disease rather than being limited to the intestines. Extra intestinal manifestations (EIMs) accompanying CD are reported at rates varying from 6 to 53%. While EIM negatively affects the quality of life of some patients, some EIMs, …
Causal effects of brain subregion gene expression on inflammatory bowel diseases revealed by Mendelian randomization and single cell analysis
Publication Year: 2025 Source: Sci Rep PMID: 40594700 DOI: 10.1038/s41598-025-08633-8
Inflammatory Bowel Diseases (IBDs), including Ulcerative Colitis (UC) and Crohn's Disease (CD), are chronic gastrointestinal disorders. The gut-brain axis integrates various signals, but its impact on IBD is unclear. Using Mendelian Randomization, we evaluated causal relationships between 13 brain subregions and colon expression quantitative trait loci (eQTLs) with IBDs. Trans-omics …
Hongyuyin attenuates intestinal fibrosis in ulcerative colitis in mice revealed by transcriptomic and network pharmacology analyses
Publication Year: 2025 Source: Sci Rep PMID: 40594739
Ulcerative colitis (UC) is a chronic, idiopathic inflammatory disease affecting the gastrointestinal tract. Hongyuyin (HYY), a traditional Chinese botanical formulation, has been effectively treating UC for over three decades; however, its underlying biological mechanism of action in UC-associated intestinal fibrosis (IF) remains unclear. This study investigated the mechanisms of action …
Need more literature?
The current database contains 98453 research articles. If you need to search for more literature or perform AI analysis, please use our knowledge acquisition module or explore external literature resources.
External Resources: Access comprehensive literature databases worldwide